IDENTIFICATION OF DISORDERS OF MOTOR UNIT

CLINICAL ANTERIOR HORN CELL PERIPHERAL NERVE NEUROMUSCULAR JUNCTION MUSCLE

SYMPTOMS

PERSISTANT WEAKNESS YES YES YES YES

VARIABLE WEAKNESS NO NO YES YES

PAINFULL CRAMPS OFTEN RARE NO RARE

MYOGLOBINURIA NO NO NO NO

PARESTHESIA NO YES NO NO

BLADDER DISORDER RARE OCCASIONAL NO NO

SIGNS

WEAKNESS YES YES YES YES

WASTING YES YES NO YES

REFLEX LOST YES YES NO (MG) YES

REFLEX INCREASED YES (ALS) NO NO NO

BABINSKI YES (ALS) NO NO NO

ACRAL SENSORY LOSS NO YES NO NO

FASCICULATION COMMON RARE NO NO

LABORATORY

SERUM ENZYMES NO or MILD NO NO YES

CSF PROTIEN YES or MILD YES NO NO

MOTOR NERVE CONDUCTION

VELOCITY NO or MILD OFTEN NO NO

AMPLITUDE or NO NO YES NO

EMG

DENERVATION YES YES NO NO

MYOPATHIC NO NO NO YES

BIOPSY

NEUROGENIC FEATURES YES YES NO NO

MYOPATHIC FEATURES NO NO NO YES

ALS, Amyotropic lateral sclerosis: MG, Myasthenia gravis

SUBMITTED BY: NAVEEN GANER

M.P.Th. 09174009