5415400959 79

1
Ibuprofen extemporaneous preparation for adults
: 8 2559
. (Master
formula)

CMC mucilage
Tween 80
70% Sorbitol
Purified water
Paraben
concentration
Flavour
Syrup qs

Mast
er

60

ml

14 ml
20 ml
5 ml
1 ml

8.4 ml
12 ml
3 ml
0.6 ml

8.4
5 ml
12 ml
3 ml
0.6 ml

0.18
ml
100
ml

0.108 ml

qs

60 ml

60 ml

Ibuprofen 400 mg/15 ml 50 ml

Ibuprofen 400 mg

Ibuprofen 400 mg/15 ml 50

ml
50 ml Ibuprofen
1333.33 mg
400 mg

400 mg x 50 ml
15 ml

= 3.33

1600 mg (4 )
=

1600 mg x 15 ml
400 mg

= 60 ml

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1.
2.
4

3.
4.
wetting

5. rinse
6. Paraben concentration
7.
8.

Master

floccule

floccule

2 cm

1.7 cm

++

+++

7-8

7-8

floccule

(redispesibility)

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pH

5.5
+

6
+

Suspension

(Caking)


Tween 80 , 5 ml Surfactant

pH stability Ibuprofen = 4-8 pH = 5.5

pH = 6 pH

floccule
floccule 78

- floccule
suspending agent



- Sorbitol Glycerin
floccule

- Buffering agent Citric acid pH

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- Wetting agent