E.

coli EIEC closely resemble Shigella in their pathogenic

O groups-shows remarkable cross reactivity with O mechanisms and the kind of clinical illness they
antigens (Shigella) produce.
Tribe Escherichiae (shigella, Escherichia) EIEC apparently lack fimbrial adhesins but do
K1 antigen= same with Neiserria meningitidis possess a specific adhesin that, as in Shigella, is
group B thought to be an outer membrane protein.
Role of K antigens in virulence
MAC AND EMB
MAC= lactose positive (pink)
EMB= green metallc sheen

Properties:
-Fermentation of glucose, lactose, trehalose and
xylose
*trehalose= natural alpha-linked disaccharide
formed by an α,α-1,1-glucoside bond between two
α-glucose units.
-Indole production from tryptophan
-Glucose fermentation by the mixed acid pathway:
methyl red positive and Voges-Proskauer negative
-Does not produce H2S, DNase, urease or
phenylalanine deaminase
-cannot use citrate as a sole carbon source

UROPATHOGENIC E.COLI
-E.coli-most common cause of UTIs in human
-E.coli strains-cause UTI originate from large
intestine as resident biota
-Can exist as predominant E.coli or small part of
E.coli
-Strains causing lower UTI and acute
pyelonephritis (immunocompressed hosts) diff.
From those causing urinary tracts
-Infants worldwide are especially susceptible to
Escherichia coli diarrhea, since they usually have
not yet
developed immunity.
-Acute pyelonephritis= dominant resident E.coli in
the colon
-Resistant to the antibacterial activity of human
serum
most common cause of urinary tract infections,
which usually occur in women and hospitalized
patients with catheters in the urethra.

-Symptoms include burning on urination

(dysuria), having to pee frequently (frequency),
and a feeling of fullness over the bladder.

-Culture of greater than 100,000 colonies of

bacteria
from the urine establishes the diagnosis of a urinary
tract infection.