Generic Name: Nimesulide

Brand Name: AULIN

Dosage: 100 mg/tab

CLASSIFICATIONS
Nonsteroidal Anti-Inflammatory Agents

ACTIONS

Physiologic Mechanism

• Relieving pain

Pharmacologic Mechanism

• Nimesulide is a selective inhibitor of the prostaglandin synthesis enzyme cyclooxygenase.

In addition, nimesulide was demonstrated to possess many other biochemical properties that are
probably responsible for its clinical properties. These include prevention of inactivation of α-1-
proteinase inhibitor, inhibition of histamine release from human basophils and mast cells,
inhibition of histamine activity

INDICATION
• Relieve pain after surgical intervention

NURSING CONSIDERATIONS
• Assess patient for pain and limitation of movement; note type, location, and intensity prior to
and at the peak following administration.
• Administer after meals or with food or an antacid to minimize gastric irritation.
• Instruct patient to take with a full glass of water and to remain in an upright position for 15-30
min after administration.
• Teach patient to report blurred vision, ringing of ears that may indicate toxicity.
• Advise patient to report change in urine pattern, edema, increased pain in joints, fever, blood in
urine that may indicate nephrotoxicity