Rabies virus

Incubation period
Entry into break in skin
(4 days – 2 years)
(bites, abrasions, mucosa)

§ Pain
§ Fever
IN V ASION § Headache
P HASE § Malaise
Ø Imminent thoraco- § Sore throat
lumbar involvement § Anorexia
(PNS): Pupillary § Increased sensitivity
dilation, lacrimation,
Ø increased thick saliva
production / foaming
of mouth, excessive
perspiration EX CITEM EN T
Ø Anxiety & fear P HASE Ø Gradual weakness of muscle groups: muscle
Ø Hydrophobia spasms cease, ocular palsy, vertigo, facial &
Ø Pronounced muscular masseter palsy, weakness of muscles of
stimulation & general phonation, loss of tendon reflexes, neck stiffness
tremor Ø (+)Babinski [lesions at pyramidal tract], (-)
Ø Mania & Kernig’s, (-) Brudzinski’s
hallucinations with Ø HR shifting from tachycardia (100-120) to
lucid intervals bradycardia (40-60)
Ø Convulsions Ø Cheyne-Stokes respiration
Ø Local sensation diminshed (pain, heat, cold)
P ARALYTIC Ø Incoordination
P HASE Ø General arousal
( DEPRESSION PHASE) Ø Bladder & intestinal retention (damage to the
innervation of the musculature of intestine &
bladder)
Ø Hydrophobia disappear but with slight difficulty
swallowing
in some cases, patient shows period of recovery,
this apparent remission is followed by rapid
progressive paralysis
Ø Ascending paralysis,flaccid paralysis of
coma extremities until it reaches the respiratory muscle
Ø Apathy, stupor

Death