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    Tasneem Ali Harasis
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    Zolpidem is a drug that is converted to inactive metabolites in the liver by several enzymes, including prostaglandin G/H synthase 1 and cytochrome P450 enzymes like 2D6, 1A2, 3A4, 2C9, and 2C19. Experimental and predicted properties of zolpidem such as logP and pKa are provided from different sources.

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    medicinal chemistry

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    Zolpidem is a drug that is converted to inactive metabolites in the liver by several enzymes, including prostaglandin G/H synthase 1 and cytochrome P450 enzymes like 2D6, 1A2, 3A4, 2C9, and 2C19. Experimental and predicted properties of zolpidem such as logP and pKa are provided from different sources.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    27 views1 page

    Medicinal Chemistry

    Uploaded by

    Tasneem Ali Harasis
    Zolpidem is a drug that is converted to inactive metabolites in the liver by several enzymes, including prostaglandin G/H synthase 1 and cytochrome P450 enzymes like 2D6, 1A2, 3A4, 2C9, and 2C19. Experimental and predicted properties of zolpidem such as logP and pKa are provided from different sources.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    of 1

    Student name : Marwa Ali AL.

    Harasis
    Student number : 20062030246

    : Zolpidem structure

    Property Value Source


    Experimental logP 1.2 PhysProp
    Properties
    pKa 6.2 Various sources
    Property Value Source
    logP 3.15 ALOGPS
    Predicted
    Properties logP 3.02 ChemAxon Molconvert
    pKa ChemAxon Molconvert

    : Metabolism
    Zolpidem is converted to inactive metabolites in the liver

    Enzyme Reaction
    Prostaglandin G/H synthase 1 methoxylation
    Cytochrome P450 2D6 methoxylation
    Cytochrome P450 2D6 methoxylation
    Cytochrome P450 1A2 methoxylation
    Cytochrome P450 1A2 methoxylation
    Cytochrome P450 3A4 methoxylation
    Cytochrome P450 3A4 methoxylation
    Cytochrome P450 2C9 methoxylation
    Cytochrome P450 2C19 methoxylation

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