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  • VKTA DK

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    Truong Thuy
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    The document discusses Vibrio cholerae, the bacteria that causes cholera. It covers the classification of V. cholerae, its biological characteristics, virulence factors and mechanisms, diagnosis, and prevention and treatment of cholera. Key points include that V. cholerae is a curved, Gram-negative rod that is motile and grows rapidly in nutrient-rich environments. Its main virulence factor is the cholera toxin, which increases intestinal fluid secretion. Diagnosis involves culture-based and molecular methods. Prevention focuses on water sanitation and oral cholera vaccines. Treatment is oral rehydration and antibiotics.

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    VKTA dk

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    The document discusses Vibrio cholerae, the bacteria that causes cholera. It covers the classification of V. cholerae, its biological characteristics, virulence factors and mechanisms, diagnosis, and prevention and treatment of cholera. Key points include that V. cholerae is a curved, Gram-negative rod that is motile and grows rapidly in nutrient-rich environments. Its main virulence factor is the cholera toxin, which increases intestinal fluid secretion. Diagnosis involves culture-based and molecular methods. Prevention focuses on water sanitation and oral cholera vaccines. Treatment is oral rehydration and antibiotics.

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    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
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    19 views16 pages

    VKTA DK

    Uploaded by

    Truong Thuy
    The document discusses Vibrio cholerae, the bacteria that causes cholera. It covers the classification of V. cholerae, its biological characteristics, virulence factors and mechanisms, diagnosis, and prevention and treatment of cholera. Key points include that V. cholerae is a curved, Gram-negative rod that is motile and grows rapidly in nutrient-rich environments. Its main virulence factor is the cholera toxin, which increases intestinal fluid secretion. Diagnosis involves culture-based and molecular methods. Prevention focuses on water sanitation and oral cholera vaccines. Treatment is oral rehydration and antibiotics.

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    of 16

    4

    Vi khun t

    (Vibrio cholerae)

    Mc tiu hc tp

    1. Trnh by c cch phn loi vi khun t. 2. Trnh by c mt s tnh cht sinh hc chnh ca vi khun t. 3. Trnh by c kh nng v c ch gy bnh ca vi khun t. 4. V v gii thch c s chn on vi sinh vt bnh t. 5. Trnh by c cc phng php phng v nguyn tc cha bnh t.

    1. Phn loi vi khun t

    vibrionaceae

    (H) (5 chi)

    vibrio (> 30 loi) V.choler ae (c in) V. Eltor Ogawa inaba Hikojim a

    v. choler ae v. cholerae 01 v. cholerae 0139 Cc VK khng gy t

    2. Mt s tnh cht chnh ca vi khun t 2.1. Hnh thi: - Hnh du phy, Gr(-). - Di ng mnh, nh 1 lng mt u. 2.2. NuI cy - Hiu kh - Pht trin nhanh trong mi trng kim. 2.3. sc khng khng - D b cht bi cc ho cht dit khun hoc 100oC. - C th sng lu trong nc khi c ng thc vt thu sinh thch hp.

    3. Kh nng gy bnh ca vi khun t 3.1. cc yu t c lc chnh ca vi khun t - CT (cholera toxin): L yu t c lc quan trng nht. - TCP (toxin coregulated pilus): Gip vi khun Gy mt nc, in gii. bm vo t bo biu - Verocell toxin: Ging c t ca S. m rut non dysenteriae 1. - Haemolysin: Ly gii hng cu. - Mt s enzym ngoi bo: Gip vi khun tn ti trong nc ngoi mi tr ng.

    3.2. C ch tc ng ca Cholera Toxin


    GM1 Tiu phn A Tiu phn
    B A2 A1 hot ho

    ATP

    adenyl cylase

    Tiu Chy Khu knh rut Mng t bo

    Nc v i n gii

    AMP vn g

    Trong t bo

    4. Chn on vi sinh bnh t 4.1. Chn on nhanh - Hin vi quang hc Soi ti Nhum Gram - Min dch hc: Hunh quang trc tip: Pht hin VK trong bnh phm. Sc k min dch: Xc nh LPS trong bnh phm. - K thut PCR: Xc nh cc gen c lc.

    4. Chn on vi sinh bnh t 4.2. phn lp, nh danh

    - Nui cy phn lp - Xc nh tnh cht ho sinh - Xc nh type huyt thanh

    S xt nghim vi khun t Phn,cht nn


    XN nhanh

    Nc

    Thc phm

    CaryBlair Thch kim, tcbs 37C/18h Pepton kim


    37C/3-6h

    Ngng kt kht

    tnh cht hO sinh Ngng kt kht kt lun

    5. phng bnh 5.1. Khng c hiu Thc hin cc bin php phng nhim trng ng tiu ho. 5.2. c hiu Ung vacxin.

    Vacxin phng t
    Biv WC (Bivalent anti 01 and 0139 - killed whole cell) - Vit Nam sn xut c rBs WC (Monovalent anti 01 recombinant B subunit killed whole cell) VX ang c trn thng trng: Duckoral.

    6. Cha bnh

    - Bi ph nc v in gii - Ung khng sinh

    Khoanh trn ch ci ng u 1 ng:

    1. Vi khun khng thuc h vi khun ng rut (Enterobacteriaceae) l: A. H. pylori B. Yersinia C. Salmonella D. Shigella

    Khoanh trn ch ci ng u 1 ng

    1. E. coli gy bnh ngoi rut (ExPEC) l: A. EIEC B. MAEC C. EAEC D. EHEC

    Khoanh trn ch ci ng u 1 ng nht:

    1. Ngoi c t l yu t c lc chnh ca: A. Vi khun thng hn B. Vi khun l C. E. coli D. Vi khun t

    Khoanh trn ch ci ng u 1 ng nht:

    1. Trng hp dch st nht l: A. Shigella : Vi khun l. B. Salmonella : Vi khun thng hn C. V. cholerae : Vi khun t D. Enterobacteriaceae : Vi khun ng rut

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