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IL1R/TLR

MyD88 IRAK

ImmuneCellRecruitment

RepairofDNA/Organelles Autophagy

TRAF6

TRAF6

TRAF6
Ub Ub Ub

TRAF6 Ub TAK1
Ub Ub

Apoptosis

P
IK

NODonors
IB

Ub Ub Ub

IK IK NEMO

P P IB
p65 p50

P P IB

NO
PGD2,PGE2

p65 p50

iNOS,COX2
B
GAS

Apoptosis

IK

Apoptosis
B

STAT1
JAK1/2 EP14 PGE2 IFNReceptor DP1 PGE2

IFN

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