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AMPK Signaling iNOS

NOProducAon
GL

P53/GenotoxicStress

mTOR Raptor
PRAS40

hVPS34 p150 PI3KIII Bcl2 Beclin1

3MA

ULKcomplex

AutophagyInducAon

Atg1

Apoptosis
Autophagosome Lysosome
Fusion

SequestraAon Phagophore Atg16 Atg12 Atg5 Atg3 Atg16 Atg5 Atg10 Atg7 Atg12 Atg7 LC3I Atg4 LC3 LC3II

PE Lysosome

Autophagolysosome

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