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IL1R/TLR

TLR4

Transporter?

MyD88

Cytoplasm
iEDAP MDP

IRAK

TRAF6
E1 Ubc13,Uev1A

TRAF6

NOD1 RICK

NOD2 RICK

TRAF6
Ub Ub Ub Ub

TRAF6
Ub Ub Ub Ub

TAK1

AcHvaHon

CARD9

AcHvaHon

ProteasomalDegradaHon

MAPKinasesp38, ERK,andJNK

IB

IK

P P
IB

P P
IB

RelA

p50

RelA

p50

RelA

p50

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