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Grant Schematic W NOD1 and NF-KB
Grant Schematic W NOD1 and NF-KB
TLR4
Transporter?
MyD88
Cytoplasm
iEDAP MDP
IRAK
TRAF6
E1 Ubc13,Uev1A
TRAF6
NOD1 RICK
NOD2 RICK
TRAF6
Ub Ub Ub Ub
TRAF6
Ub Ub Ub Ub
TAK1
AcHvaHon
CARD9
AcHvaHon
ProteasomalDegradaHon
MAPKinasesp38, ERK,andJNK
IB
IK
P P
IB
P P
IB
RelA
p50
RelA
p50
RelA
p50