W IN1kCDUC1ICN

W valsarLan ls an anLlhyperLenslve agenL wlLh low solublllLy

and hlgh permeablllLy
W 8loavallablllLy of valsarLan ls very low
W Cne of Lhe way of lncreaslng Lhe dlssoluLlon raLe of poorly
soluble drug ls by formulaLlng fasL dlssolvlng LableLs
W lasL dlssolvlng LableLs are prepared by uslng varlous
superdlslnLegraLlng agenLs whlch helps Lo dlslnLegraLe
LableL aL fasLer raLe
W Pence bloavallablllLy of such drugs can be lncreased
slgnlflcanLly
C8ILC1IVL
W @o lmprove Lhe dlssoluLlon raLe of poorly soluble valsarLan by
uslng superdlslnLegranLs
W @o sLudy Lhe effecL of pP and parLlcle slze on solublllLy of valsarLan
,aLerlals used
W valsarLan,lcrocrysLalllne celluloseACul
solCrospovldone
W the |ngred|ents were coground |n a peste and mortar and then tac and
magnes|um stearate were added and m|xed for 10 m|nutes
W1he m|xed bend of drugexc|p|ent was compressed us|ng d|rect compress|on
W1h|s techn|que can now be app|ed to preparat|on of ID1 because of
the ava|ab||ty of |mproved exc|p|ents espec|ay superd|s|ntegrants (Lg Lud|press
Ceactose)and sugar based exc|p|ents Lg Lactosematose
reparat|on of ID1 of vasartan
kLICkMUL1ICN S1UDILS
1abe1 INILULNCL CI n CI SCLVLN1 CN SCLU8ILI1 CI
VLSk1N
hys|ca parameters of Vasartan fast ID1 formuated w|th phys|ca m|xture
of superd|s|ntegrant
SNC parameter I19 I20 I21
JL varlaLlon 20 200 20
2 lrlablllLy() 078 088 079
3 Pardness(kg/cm2) 33 40 33
4 urug conLenL() 963 990 994
3 ulslnLegraLlon
Llme(mln)
27 30 34
W @able2 lnfluence of parLlcle slze on solublllLy
of valsarLan ln 68 phospaLe buffer
kLk1ICN CI CCkCCLSSLD
SULkDISIN1LGkN1S
W @hey were prepared by solvenL evaporaLlon meLhod
W Crospovldone and AculSol were Laken ln Lhe raLlo as
shown ln @able3@hen add 0 ml of eLhanol Lo above
mlxLures
W @he weL coherenL mass was granulaLed Lhrough # 60
mesh sleve
W @he weL granules were drled ln a hoL alr oven aL 60 C
for 20 mlnuLes @he drled
W @he granules were slfLed Lhrough # 60 mesh sleve and
sLored ln alrLlghL conLalner Llll furLher use
W ComposlLlon of valsarLan lu@ formulaLed
wlLh physlcal mlxer of superdlslnLegranLs
W APlnvlLro dlssoluLlon raLe of lu@ of
valsarLan
W @A8LL3 lnvlLro dlssoluLlon proflle of
valsarLan lu@ formulaLed wlLh physlcal
mlxLure of superdlslnLegranLs
W hyslcal parameLers of valsarLan lu@
formulaLed wlLh physlcal mlxLure of
superdlslnLegranLs
lnvlLro dlssoluLlon sLudles
W lL ls performed uslng uS @u@08L Lype 2 dlssoluLlon LesL
W apparaLus
W varlous dlssoluLlon medla wlLh dlfferenL , was Laken as
per@A8LL4
W @he dlssoluLlon medlum was malnLalned aL a LemperaLure of 3703
'C and samples are wlLhdrawn aL an lnLerval of every 3 mln
W @he volumes of Lhe wlLhdrawn samples are replaced by fresh
dlssoluLlon medlum ln order Lo keep Lhe volume of Lhe dlssoluLlon
medlum consLanL
W @he wlLhdrawn samples were fllLered and absorbance was
measured aL absorpLlon maxlma of 230 nm uslng uvvlslble
specLrophoLomeLer
W @A8LL3lnvlLro dlssoluLlon proflles of
valsarLan LableLs ln four dlssoluLlon medlums
aL 00 rpm
W AP2 lnvlLro dlssoluLlon raLe of valsarLan
LableLs ln four dlssoluLlon medlums aL 00
rpm
W
d|ssout|on prof|es of Vasartan marketed tabets |n four d|ssout|on med|ums at 100
rpm
W Concluslon
W ulssoluLlon raLe was found Lo be lnfluenced by
naLure of comblnaLlon of superdlslnLegranLs
employed
esulL
W @ableLs formulaLed wlLh coprocessed
crospovldoneand ACulsol ln raLlo ls besL Lo
formulaLe fasL dlssolvlng LableLs
W valsarLan showed pP dependenL solublllLy
W P 68 phosphaLe buffer aL 00 rpm was Lhe besL
dlssoluLlon medlum for valsarLan LableLs
W @he solublllLy can be lmproved by reduclng Lhe
parLlcle slze
0
20
40
60
80
00
20
0 3 0 3 20 23 30
0 n PCl A 0 n PCl 8 43 ACL@A@L 8ullL A
43 ACL@A@L 8ullL 8 68 PCSPA@L 8ullL A 68 PCSPA@L 8ullL 8
JA@L A JA@L 8

D
k
U
G

k
L
L
L

S
L
1IML (m|n)
d|ssout|on data of Vasartan fast d|ssov|ng tabets formuated
w|th phys|ca m|xture of superd|s|ntegrants (Crospov|done and cD|
So)(11 rat|o)
I|rst order pots of Vasartan fast d|ssov|ng tabets formuated w|th phys|ca
m|xture of superd|s|ntegrants (Crospov|done and cD|So 11 rat|o
0
03

3
2
23
0 3 0 3 20 23 30
l9 l20 l2
L
C
G

C
I

D
k
U
G

k
L
L
L

S
L
1IML (m|n)
Concluslon
W valsarLan showed pP dependenL solublllLy
W @he solublllLy was found Lo be lnfluenced by
Lhe parLlcle slze of pure drug @he solublllLy
can be lmproved by reduclng Lhe parLlcle slze
W ulssoluLlon raLe was found Lo be lnfluenced by
naLure of comblnaLlon of superdlslnLegranLs
employed
W esulL
P 68 phosphaLe buffer aL 00 rpm was Lhe
besL dlssoluLlon medlum for valsarLan LableLs
2 @ableLs formulaLed wlLh coprocessed
crospovldone ACulsol ln raLlo ls besL Lo
formulaLe fasL dlssolvlng LableLs
eference
W ueb[lL 8howmlk 8!ayakar and kSampaLh kumar ueslgn and
CharacLerlsaLlon of lasL ulssolvlng @ableL of @elmlsarLan"
lIlkk 2009 () 3
W C !aln and S naruka lormulaLlon and evaluaLlon of fasL
dlssolvlng LableLs of valsarLan" lotetootloool Iootool of
lbotmocy ooJ lbotmoceotlcol 5cleoces vol lssue !uly
Sep 2009 29227