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Altered Repolarization of the Myocardium

Release of Lysosomal Enzymes Anaerobic Glycolysis Myocardial Irritability Decreased Contractility DYSRHYTHM IA Ventricular Function Lactic Acid Production

ANGIN A

Preload

CO

Blood Flow to Brain

LOSS OF CONSCIOUSNESS

Enlargement of Thrombus Occlusive Thrombus

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WEAKNESS/FATIGUE (JULY 1719)

Ischemia of Tissue in Region Supplied by Artery

PALPITATION S

O2
Coronary Blood Supply Less Than Demand CO2 levels Bld pH

MYOCARDIAL CELL DEATH (NECROSIS)

DEEP & LABORED BREATHIN G

Stimulation of Sympathetic NS

HR

O2 need

Afterload Vasoconstrictio n

Epinephrine & Norepinephrin e Production BMR

HTN

ARRHYTHMI A

Blood Supply to GI Tract

DIAPHORESI S

N/V

PATHOPHYSIOLOGY OF ACUTE MI (BOOKBASED) www.NursesLabs.com .

ACUTE MYOCARDIAL INFARCTION

MODIFIABLE FACTORS: Hypertension Smoking levels of triglyceride, total cholesterol & LDL DM Obesity Excessive intake of saturated fats, carbohydrates or salt Sedentary lifestyle/physical inactivity Stress/Type A personality Drug Abuse

NONMODIFIABLE FACTORS: (+) Family Hx of AMI Aging Men and Postmenopausal Women

Change in the Condition of Plaque in the Coronary Artery Activation of Platelets Platelet Aggregation, Adhesion, & Buildup of Platelet Mass ATHEROSCLEROSI S

Rest Pain

Claudication

THROMBOSIS

N/V

Release of Thromboplastin Platelet release Thromboxane A2, Serotonin, Platelet Factors 3 & 4 Coagulation and Vasospasm

Fainting

Sweating

Cool extremities

Enlargement of Thrombus