Scribd Logo
Upload

Welcome to Scribd!

  • Kuliah Hormone 8 Juli 2010

    Uploaded by

    omancacussayang
    10 views16 pages
    This document discusses various hormones and hormone antagonists. It outlines common hormones like progesterone, estrogen, testosterone, thyroxine, and insulin. It describes how hormones are regulated by the hypothalamus and pituitary gland and transported via bloodstream. Conditions of hypersecretion and hyposecretion are explained. Clinical uses of hormones are provided along with potential side effects and toxicities of hyper hormonal and hypo hormonal states. Specific hormone preparations like estrogen, progesterone, and corticosteroids are outlined with their pharmacodynamics and pharmacokinetics. The roles of these hormones in menstrual cycles, family planning, and hormone replacement therapy are summarized.

    Original Description:

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPT, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document discusses various hormones and hormone antagonists. It outlines common hormones like progesterone, estrogen, testosterone, thyroxine, and insulin. It describes how hormones are regulated by the hypothalamus and pituitary gland and transported via bloodstream. Conditions of hypersecretion and hyposecretion are explained. Clinical uses of hormones are provided along with potential side effects and toxicities of hyper hormonal and hypo hormonal states. Specific hormone preparations like estrogen, progesterone, and corticosteroids are outlined with their pharmacodynamics and pharmacokinetics. The roles of these hormones in menstrual cycles, family planning, and hormone replacement therapy are summarized.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    10 views16 pages

    Kuliah Hormone 8 Juli 2010

    Uploaded by

    omancacussayang
    This document discusses various hormones and hormone antagonists. It outlines common hormones like progesterone, estrogen, testosterone, thyroxine, and insulin. It describes how hormones are regulated by the hypothalamus and pituitary gland and transported via bloodstream. Conditions of hypersecretion and hyposecretion are explained. Clinical uses of hormones are provided along with potential side effects and toxicities of hyper hormonal and hypo hormonal states. Specific hormone preparations like estrogen, progesterone, and corticosteroids are outlined with their pharmacodynamics and pharmacokinetics. The roles of these hormones in menstrual cycles, family planning, and hormone replacement therapy are summarized.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPT, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 16

    HORMONE & HORMONE ANTAGONIST

    Anom Murdhana

    COMMON HORMONE
    PROGESTERON & ESTROGEN
    TESTOSTERONE

    GLUKOKORTIKOID ( KORTIKOSTEROID)

    THYROXINE

    INSULIN

    REGULASI

    HYPOPHYSE

    GLAND, DUCTLESS

    FEED BACK

    HORMONE

    TISSUE physiologic

    BLOODSTREAM

    HYPERSECRETION

    HYPOPHYSE

    GLAND, DUCTLESS

    FEED BACK

    HORMONE

    TISSUE

    BLOODSTREAM

    HYPOSECRETION

    HYPOPHYSE

    GLAND, DUCTLESS

    FEED BACK

    HORMONE

    TISSUE

    BLOODSTREAM

    CLINICAL USE

    SIDE EFFECT / TOXICITY

    HYPER HORMONAL

    NON HORMONAL ?
    HORMONE HORMONE

    PHYSIOLOGIC / BALANCE

    SIDE EFFECT / TOXICITY

    HYPO HORMONAL

    HORMONE PREPARAT

    ESTROGEN & ANTI ESTROGEN


    Natural & sintetis

    PROGESTERON
    Natural & sintetis

    SIKLUS MENSTRUASI
    FSH LH HYPHOPHYSIS

    OVARIUM

    ESTROGEN PROGESTERON
    UTERUS; VAGINA; MAMMA Sex secondair Metabolisme Cardiovascular Darah

    HORMONE PREPARAT
    EFEK FISIOLOGIS
    ESTROGEN
    Natural & sintetis

    PROGESTERON
    Natural & sintetis

    UTERUS; VAGINA; MAMMA Sex secondair Metabolisme Cardiovascular Darah

    HORMONE PREPARAT
    ESTROGEN
    Natural & sintetis

    * * * * * *

    Pharmacodynamics Uterus proliferation: endometrial, cervical mucus Breast glandular development Skeletal growth, antiresorptive effectsl Behaviora libido, mood CNS feedback, vasomotor stability Hepatic binding glob, lipoprotein, coagulant protein

    Pharmacokinetics
    Absorpsi Sirkulasi (SHBG & Alb (99 %) Metab (Liver) Ekskresi (Usus & Ginjal)

    HORMONE PREPARAT
    PROGESTERONE
    Natural & sintetis

    Pharmacodynamics * Uterus endometrial ? * Breast glandular development * CNS feedback * Hepatic binding glob, lipoprotein, coagulant protein

    Pharmacokinetics
    Absorpsi Sirkulasi Metab (Liver) Ekskresi (Usus & Ginjal)

    HORMONE PREPARAT
    ESTROGEN & PROGESTERON

    MENSTRUAL DISTURBANCE

    NON HORMONAL ?
    FAMILY PLANNING

    PHYSIOLOGIC / BALANCE Hormone Replacement Therapy Terapi Sulih Hormon

    SIDE EFFECT / TOXICITY HYPER HORMONAL HYPO HORMONAL

    ANTI ESTROGEN (agonist)


    ovulation-inducing agents

    Clomiphene
    Partial estrogen agonist stimulation ovulation 50 mg daily. 5 days plasma half life 7 days

    ovary enlargement hot flushes

    Tamoxifen breast cancer Raloxifene postmenopausal osteoporosis

    CORTEX ADRENAL
    GLUCOCORTICOID -- CORTICOSTEROID * Short acting (hidrocortisone / prednison) * Intermediate acting * Long acting

    Physiologic affect * Metabolic effect * Catabolic & antianabolic effect * Anti inflammatory & immunosuppressive

    HORMONE PREPARAT

    CORTICOSTEROID ( PREDNISON )
    ANTI INFLAMMATORY IMMUNOSUPPRESEIVE

    HYPOSTEROID

    ( ADDISON,S DISEASE)
    INFLAMATION IMMUNE RESPONSE

    METABOLIC ANABOLIC

    CUSHING SYNDROOM
    SIDE EFFECT / TOXICITY
    HYPERGLYCEMIA HYPERTENSION

    TERIMA KASIH

    semoga sukses

    You might also like