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  • Making Connections Genes, Lifestyle, Environment

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    Sherlaine Baas
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    Genes and lifestyle and environmental factors can interact to influence cancer risk. Not everyone who inherits gene mutations or is exposed to environmental risk factors will necessarily develop cancer. Gene mutations can be inherited from parents or acquired during one's lifetime from environmental exposures like tobacco or radiation. Epigenetic factors like DNA methylation and histone modification can also impact gene expression and cancer risk without altering the DNA sequence. Environmental exposures linked to higher cancer risk include tobacco, certain diets, hormones, obesity, alcohol, radiation, infections, and occupational hazards like asbestos.

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    Module 9

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    Genes and lifestyle and environmental factors can interact to influence cancer risk. Not everyone who inherits gene mutations or is exposed to environmental risk factors will necessarily develop cancer. Gene mutations can be inherited from parents or acquired during one's lifetime from environmental exposures like tobacco or radiation. Epigenetic factors like DNA methylation and histone modification can also impact gene expression and cancer risk without altering the DNA sequence. Environmental exposures linked to higher cancer risk include tobacco, certain diets, hormones, obesity, alcohol, radiation, infections, and occupational hazards like asbestos.

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    7 views8 pages

    Making Connections Genes, Lifestyle, Environment

    Uploaded by

    Sherlaine Baas
    Genes and lifestyle and environmental factors can interact to influence cancer risk. Not everyone who inherits gene mutations or is exposed to environmental risk factors will necessarily develop cancer. Gene mutations can be inherited from parents or acquired during one's lifetime from environmental exposures like tobacco or radiation. Epigenetic factors like DNA methylation and histone modification can also impact gene expression and cancer risk without altering the DNA sequence. Environmental exposures linked to higher cancer risk include tobacco, certain diets, hormones, obesity, alcohol, radiation, infections, and occupational hazards like asbestos.

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    Attribution Non-Commercial (BY-NC)
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    of 8

    Module 9

    Making connections Genes, lifestyle, environment

    Not everyone who has genetic mutations will develop cancer

    Genes
    Acquired

    Mutations
    Inherited

    Interactions

    mutations

    environment

    lifestyle

    Epigenetic factors
    No change in DNA changes in gene expression as cells divide = Suppression
    Methylation
    covalent addition of a methyl group

    Histone modification

    Environmental factors
    Tobacco use
    Over 60 carcinogens 30% of all cancer deaths Lung, bladder, pancreas, kidney, oral cavity, pharynx, larynx, esophagus, breast, stomach, liver cancer

    Diet
    Xenobiotics, nitrosamines, aflatoxins

    Environmental factors
    Hormones Obesity
    Pro-inflammatory state

    Alcohol
    Direct epithelial cell toxicity
    Toxic oxygen radicals

    Ionizing radiation Ultra violet radiation

    Environmental factors
    STDs
    HPV

    Physical Activity Occupational hazards


    Asbestos mesothelioma

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