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  • Abstract P'sundani

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    1. The research aims to nanoencapsulate papain for gastric resistant formulations and to increase absorption through the intestinal mucosa. 2. Papain was successfully microencapsulated using HPMCP HP-55, which is resistant to acid attack in the stomach. However, reducing particle size could further improve absorption in the intestines. 3. The researchers produced papain nanoparticles using gastric resistant materials like HPMCP HP-55, Eudragit RL PO, PVA and Tween 80 via an emulsion evaporation method with a sonicator and ultracentrifuge. The resulting nanoparticles were in the nanometer scale (600 nm) with a 59% yield and 19% efficiency.

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    Abstract p'Sundani

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    1. The research aims to nanoencapsulate papain for gastric resistant formulations and to increase absorption through the intestinal mucosa. 2. Papain was successfully microencapsulated using HPMCP HP-55, which is resistant to acid attack in the stomach. However, reducing particle size could further improve absorption in the intestines. 3. The researchers produced papain nanoparticles using gastric resistant materials like HPMCP HP-55, Eudragit RL PO, PVA and Tween 80 via an emulsion evaporation method with a sonicator and ultracentrifuge. The resulting nanoparticles were in the nanometer scale (600 nm) with a 59% yield and 19% efficiency.

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    6 views1 page

    Abstract P'sundani

    Uploaded by

    narutotriyan
    1. The research aims to nanoencapsulate papain for gastric resistant formulations and to increase absorption through the intestinal mucosa. 2. Papain was successfully microencapsulated using HPMCP HP-55, which is resistant to acid attack in the stomach. However, reducing particle size could further improve absorption in the intestines. 3. The researchers produced papain nanoparticles using gastric resistant materials like HPMCP HP-55, Eudragit RL PO, PVA and Tween 80 via an emulsion evaporation method with a sonicator and ultracentrifuge. The resulting nanoparticles were in the nanometer scale (600 nm) with a 59% yield and 19% efficiency.

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    ABSTRACT 1.

    TITLE OF RESEARCH : Nanoenkapsulasi Papain Untuk Sediaan Gastric Resistance Dan Peningkatan Absorpsi Melalui Mukosa Usus Sundani Nurono Soewandhi Teddy Wirawan, Erizal, Hestiary Ratih

    2. 3. 4.

    HEAD OF RESEARCH TEAM TEAM MEMBERS OFFICIAL ADDRESS School of Pharmacy of ITB

    : : :

    Jalan Ganesha No. 10, Bandung 40132 sundani@fa.itb.ac.id 5. EXTENDED ABSTRACT :

    Papain is one of some enzymes that can be destroyed by acidic fluid of the stomach. It was sucsessfull to produce microenacapsulated papain by using HPMCP HP-55 which is resistance to acid attack. In order to improve the amount of papain that can be absorbed through intestinal mucose, their particle size should be reduced as small as possible. In this case, the nanotechnology was choosen. Papain nanoparticle was made by gastric resistance materials like HPMCP HP-55, Eudragit RL PO, PVA and Tween 80, used the emulsion evaporation method, sonicator and ultracentrifuge. To identify the physical character of nanoparticle, scanning electron microscope and polarization microscope were used. The nanoparticle of papain produced, was in nanometer scale (600 nm), 59% rendemen and had 19% efficiency.

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