2, 4, 5, 6, 7, 8

/ sulfonylurea, biguanides
Dosage forms: tablets
Patient : Product : Social 7 : 2 : 1
Recall : Interpretation : Problem-solving 0: 4 : 6

------------------------------------------------------------------------------------------------------------------------------- 60

Glibenclamide 1 tab OD
1 2

1 ( Pt, I, DF 0.4)
1 1 (Type 1 DM)
2 1 (Type 1 DM)

3 2 (Type 2 DM)
4 2 (Type 2 DM)
5
(3)
2 (Pt, R, DF 0.4)
1 1 (Type 1 DM)

2 2 (Type 2 DM)
3 Type 2 DM ketoacidosis
4
5
(4)

3 (Pt, P, DF 0.3)
1
2
3
4

(4)
5
4
(Pd, P, DF 0.4)
1
2
3
4
5
(1)
5.
(Pt, P, DF 0.4)
1 Metformin
2 Chlorproplamide
3 Gliclazide
4 Tolbutamide
5 Insulin
(1)
6 (Pt, R, DF 0.5)
1
2
3
4
5
(4)
7.

( S, I, DF 0.3)
1

2
3
4
5 (4)
8 (Pt,
P, DF 0.6)
1
2 nicotine
3
4
5 nicotine
(4)
9. 10 uniformity of unit dosage form
125 s (sample standard deviation) 5 RSD
(relative standard deviation) (Pd, I, D.F.06)
1. 2%
2. 3%
3. 4%
4. 5%
5. 6%
(3)
10. glibenclamide (Pd, I, D. F.0.3)
Cl

OCH3
O
O

1.
2.
3.
4.

N
H

O O
N
H

N
H H

polarized
HPLC-UV detection

5. para methoxy

(5)

Pt (patient)
Pd (product)
S (social)
R (recall)
I (interpretation)
P (problem solving)
D.F. difficulty factor 1
D.F. 0.2-0.8