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Pathophysiology of CHOLELITHIASIS

1. This document discusses predisposing and precipitating factors for gallstones, which include family history, female gender, middle age, diet, obesity, rapid weight loss, oral contraceptive use, and certain gastrointestinal diseases. 2. MRI results showed dilated cystic side branches communicating with the pancreatic duct, multiple gallstones, and renal cysts. 3. The pathophysiology of cholelithiasis or gallstone formation involves increased bile cholesterol precipitating out of bile in the gallbladder, forming small crystals that enlarge into visible stones over time as mucus secretion and impaired gallbladder emptying occur.

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Liza Marie Cayetano Adarne
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8K views2 pages

Pathophysiology of CHOLELITHIASIS

1. This document discusses predisposing and precipitating factors for gallstones, which include family history, female gender, middle age, diet, obesity, rapid weight loss, oral contraceptive use, and certain gastrointestinal diseases. 2. MRI results showed dilated cystic side branches communicating with the pancreatic duct, multiple gallstones, and renal cysts. 3. The pathophysiology of cholelithiasis or gallstone formation involves increased bile cholesterol precipitating out of bile in the gallbladder, forming small crystals that enlarge into visible stones over time as mucus secretion and impaired gallbladder emptying occur.

Uploaded by

Liza Marie Cayetano Adarne
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as DOCX, PDF, TXT or read online on Scribd
  • Gallbladder Disease Overview: Explains the predisposing and precipitating factors related to gallbladder diseases through flowcharts, outlining potential diagnostic considerations.
  • Gallbladder Disease Complications: Describes the potential complications or outcomes from gallbladder disease, focusing on related symptoms and conditions as shown in detailed diagrams.

PREDISPOSING FACTORS:

Family History
Female
Middle age

PRECIPITATING FACTORS:
Diet
Obesity
Rapid weight loss
Use of oral contraceptives
Gallbladder, pancreatic or ileal disease
Low HDL cholesterol level
Hypertriglyceridemia
MRI RESULTS:
1. Dilated cystic side branches in direct
communication with pancreatic duct in the
region of uncinate process for which an IPMT
should be excluded

2. Multiple gallstones
3. Left renal cysts with wall calcifications
4. Tiny right renal corticocysts
5. Ascending and descending diverticula
CHOLELITHIASIS
Gallstones in the Bile duct

Increased Bile Cholesterol

Precipitate out of the bile


Irritation of Gallbladder
mucosa
Forms small crystals into
Gallbladders mucosal surface

Surface Changes
Enlarges to grossly visible stones
Increased Mucus Secretion
Several stones develop
Impaired Gallbladder
emptying

Obstruction

Distension

Bile Stasis

Contractile
function

Intraductal
Pressure

Biliary
Colic

RUQ
Pain

Injury

Bile
accumulates
in Liver

Jaundice

Biliary
Cirrhosis

Increase
Serum
Bilirubin

Abnormal
Fat
Digestion

Prorates/Tea
-collared
Urine

Anorexia
Nausea
Vomiting
Weight loss
Flatulence
Diarrhea
Fat
intolerance

Inflammation of
Gallbladder
Cholecystitis

Inflammat
Gallblad

Distension Intraductal Pressure RUQ Pain Biliary Co

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