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  • Metabolisme Bilirubin

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    The document discusses the mechanism of bilirubin in the body. Bilirubin is produced from the breakdown of heme in red blood cells by heme oxygenase in the spleen and bone marrow. It is then converted to biliverdin and ultimately conjugated bilirubin in the liver. Conjugated bilirubin is excreted in bile and enters the small intestine where it is broken down into urobilinogen and ultimately produces the pigments that color urine and feces.

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    table metabolisme bilirubin

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    The document discusses the mechanism of bilirubin in the body. Bilirubin is produced from the breakdown of heme in red blood cells by heme oxygenase in the spleen and bone marrow. It is then converted to biliverdin and ultimately conjugated bilirubin in the liver. Conjugated bilirubin is excreted in bile and enters the small intestine where it is broken down into urobilinogen and ultimately produces the pigments that color urine and feces.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    50 views2 pages

    Metabolisme Bilirubin

    Uploaded by

    Anonymous lSWQIQ
    The document discusses the mechanism of bilirubin in the body. Bilirubin is produced from the breakdown of heme in red blood cells by heme oxygenase in the spleen and bone marrow. It is then converted to biliverdin and ultimately conjugated bilirubin in the liver. Conjugated bilirubin is excreted in bile and enters the small intestine where it is broken down into urobilinogen and ultimately produces the pigments that color urine and feces.

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    © All Rights Reserved
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    of 2

    MEKANISME BILIRUBIN

    globin

    Asam amino recycle

    Hemoglobin
    RETICULOCYTE
    ENDOTHELIAL
    CELL; SPLEEN;
    BONE MARROW;
    LIVER

    Fe recycle

    Heme
    CO expired

    Heme oksigenase
    O2, NADPH + H+

    3+

    Fe , CO
    NADP+
    Biliverdin ----- hijau

    Biliverdin reduktase

    NADPH + H+

    NADP+
    Bilirubin (unconjugated) ----- kuning
    Circulating-bilirubin albumin complex

    PLASMA DARAH

    Bilirubin-ligandin complex
    2 UDP-glucoronis acid

    bilirubin

    glukoronosil transferase
    2 UDP
    - dan - bilirubin glucuronide

    bakteri glukoronidase
    DUCT
    Siklus

    Urobilinogen ----- tdk berwarna

    HEPATOCYTE

    BILE
    SMALL INTESTINE

    Enterohepatic

    Stercobilinogen
    GINJA

    COLON

    Urobilin & stercobilin

    mewarnai urine

    Mewarnai FECES

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