Assignment # 2

Introduction
to
Nano
biotechnology
Nano-gate Implant

Submitted to: Dr. Zahra

Submitted by: Irum
Date: 2Nov, 2015

Nano-Gate Implant
What is Nano-gate implant
Nano-gate implant is a nanostructured-material based technology designed for constant
passive diffusion of drug through a Nano-pore membrane engineered to exact size and
requirement of individual molecules.
The company developed Nano-GATE, a small cylindrical implant inserted under the skin
providing a continuous alpha interferon release for 36 months.

Composition and structure of Nano-gate implant

Nano-gate implant is composed of Nano-pore membranes that are important for the
fabrication of Nano-gate implant, and silicon films with parallel rectangular channels

arrays of 450 nm in diameter.

Nano-gate implant is fitted around by 400 microliter reservoirs 12cm in length and 35cm
diameter capped at both ends of Nano-gate implant, membranes controls the diffusion of

drugs from the capsule, providing a continuous release of drug for from 3-6 months.
Nano-gate implant is 4-5mm in diameter and 20-35mm in length with a 75-300microlitre

reservoir that contain a suspension or solid-state drug formula.

The carrier is fitted with two silicone O-rings and inserted into the titanium encasement.

Fig1.
This is structure of Nano-gate implant capped at both ends, having nano-pore membrane
of 2mm width, fitted with 2 O-rings of silicon inserted into titanium encasement.

Biocompatibility of Nano-gate implant

Biocompatibility of Nano-gate implant is due to non-fouling of silicon Nano-pore membranes.
After contact with body, when cells proteins and other biological components adhere to the

surface these do not limit diffusion of molecules. So Nano-gate implant is completely functional
in-vivo, and release drug constantly over extended time period.

Applications of Nano-gate implant

Nano gate implant use in:
Drug delivery system
Nano gate in Bio filtration.

Nano-gate implant in drug delivery

The nano-gate implant is used in drug delivery system.

Principle
As implant is composed of nanpore membrane so the drug is filled upon arranging the membrane
with titanium grate opening. Nano-pore membrane that is made up of silicon film controls the
drug diffusion. Pore size is designed according to size of drug molecules.
Nano-gate implant technology is diffusion driven, that provide more space for drug formulation.
It can be used for targeted delivery of alpha-interferon to the tumor site but side effects may be
observed.
It is suitable for the delivery of protein and peptide drugs.

Advantages

Drug is protected by immunological reaction of body by nano-pore membrane, it releases

the drug but prevent the entry of unwanted cells.

They are biocompatible and biodegradable
Provides controlled release and improve solubility of hydrophobic drugs.