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4- 5
(
)
1.
2.
3. systemic side effect

Topical

4.
5.
(U.S. Food and Drug
11
Administration; US FDA)
Teratogenity 5
FDA Pregnancy Category
Category A :
Category B :
Category C :
Category D :
11
Category X :

Teratogenicity
teratogenicity
11
1.
2.

3.
( milk to plasma ratio: M/P ratio )
4.

5.

6.

7.
8.
9.

11
4-5
3-4
10.

11.
Definitions of Lactation Recommendations(From Hale)
Category L1 (safest) ;
Category L2 (safer) ;
Category L3 (moderately safe) ;
11
Category L4 (possibly hazardous) ;
Category L5 (contraindicated) ;
Pregnancy Category and Lactation Category
11
Acetylcysteine
Pregnancy Risk
Category
B
Lactation Risk
Category
No human Data-probably
11
compatible
Actifed(Triprolidine+Psudo
ephredrine)
L3
Activated chacoal
Compatible
Acyclovir
Adrenalin
C
D
L2
compatible
Albendazole
Alcohol
L3
trimester)
No Data
Aliskiren
Allopurinol
Allum Milk+Simeticone
Alprazolam
Alumenium + Magnesium
D(2nd and 3 rd
C
C
D
compatible
L2
compatible
Limited human Datapotential toxicity
Hydroxide
Compatible
Aminophyllin
Compatible
Amitryptyline
Amlodipine
Ammonium carbonate
Amoxycillin
Amoxycillin+Clavulonic
acid(Augmentin)
No data available
No Data
No Data
L2
L1
11
Ampicillin
Aspirin(enteric coated)
Atenolol
Atropin so4
Azithromycin
C
B
L1
L3
L3
Limited human Dataprobably compatible
A(RDA
recommened
B1-6-12
Bactrim(Trimethoprim+Sulf
dose)
C/ D(3rd
L1
amethoxazole)
trimester)
L3
Benadyl
No Data
No Data
Benz. Penicillin
L1
(Ipratopium+Fenoterol )
compatible
Pregnancy Risk
Lactation Risk
Category
Category
Berodual
Betahistine
No Data
No Data
C/ D(1st
Betamethasone
trimester)
Bisacodyl
Bromhexin
No Data
Brown mixt
No Data
No Data
compatible
compatible
No Data
11
Calcium gluconate
No Data
Calcium carbonate
No Data
X
No Data
Contraindication
Carminative Mixture
No Data
No Data
Carfein+Ergometine
Ceftriaxone
L2
Limited human Data-
Chloramphenical
Chloroquin
Chlorpheniramine
Chlorpromazine
Cilostazole
potential toxicity
Clobethazone
No Data
Clonazepam
Clorazepate
D
B
Compatible
Cloxacillin
Colchicin
Compatible
Dapsone
L4
Ciprofloxacin
Clotrimazole
Dexamethasone
DexOph(Dexamethasone+N
eomycin)
potential toxicity
L3
compatible
Limited human DataL3
No human Data-potential
toxicity
L4
C/ D(1st
Limited human Data-
trimester)
potential toxicity
No Data
11
Dextromethophen
Diazepam
C
D
Compatible
B/ D(3rd
Dicloxacillin
Compatible
Digoxin
L2
Dimenhydrinate
compatible
Domperidone
L1
Dopamine HCL
inhibit lactation
Pregnancy Risk
Lactation Risk
Diclofenac
Didanozine
Dipyridamole
Doxycycline
trimester)
B
Category
D
(contraindication
compatible
L5
L2
No human Data-may
Category
Compatible
in 2nd&3rd
trimester)
Efavirenz
Contraindication
Enalapril
trimester)
L2
Ephedrine
Erytromycin
C/ D(2nd,3rd
B(exclude estolate
L1; L3 early postnatal
11
salt)
Estrogen+Progesterone
(Pill)
L3
Ethambutol
L2
above RDA)
Compatible
high dose)
L2
FBC
Fentanyl
Ferrous sulfate drop

Fluconazole
Flunarizine
Fluoxetine
Fluphenazine Decaoate
Folic acid
A /C(if dose
C/D (prolong and
A
Compatible
L2
No Data
No Data
Limited human Data-
C/D
potential toxicity
C
(1st&2nd
toxicity
Compatible
trimester),
C (3rd trimester)
Furosemide
C/D
Gemfibrozil
Gentamycin
Glibencamide
Gliclazide
toxicity
L2

No Data
11
Limited human DataGlipizide
Glucosamine sulfate
compatible
+AZT)
L5
Griseofulvin
Guaifenesin
Haloperidol
potential toxicity
Pregnancy Risk
Lactation Risk
GPO-VIR S
probably compatible
L5
GPO-VIR
Z(Nervirapine+Lamivudine
HBV
toxicity
compatible
Limited human Data-
Category
Category
compatible
No Data
No Data
Hydrogen peroxide
No Data
No Data
Hydroxyzine HCL
Hyoscine-n-butybromide
Ibruprofen
Hista-oph
Hydrochlorothiazide
L2
compatible
B/
compatible
L1
11
D(3rd trimester or
near delivery)
Limited human Data-
Imipramine
potential toxicity
Isoniazid
L3
Isosorbide dinitrate
Itraconazole
Ketamine HCL(Ketalar)
compatible
Lamivudine
L5
Levodopa +carbidopa
probably compatible
Lincomycin
Compatible
Lithium carbonate
potential toxicity
Loratadine
L1
Lorazepam
Insulin
Ketoconazole
Lidocain
Lopinavir
Losartan
Magnesium sulfate
Mebendazole
B/C
Compatible
compatible
L2
C/D(2nd and 3rd
trimester)
compatible
Limited human Data-
L1
11
probably compatible
Medroxyprogesterone
Mefenamic acid
Meloxicam
Metformin HCL
Methotrexate
Limited human Data-
C/D(2nd and 3rd
Limited human Data-
trimester)
probably compatible
trimester)
Pregnancy Risk
Category
B
X
B
Metronidazole
Misoprostol(Cytotec)
Moduretic(Amiloride+HCT
(Contraindication
in 1st trimester)
B
Z)
C/D
Morphine
C/D
Multivitamin
Nebivolol HCL
3days postpartum)
C/D(2nd and 3rd
Metoclopramide
Milk of magnesia
L1 ;(L4 if used first
probably compatible
Lactation Risk
Category
Compatible
L5

L1
compatible
L3
No Data
11
Nervirapine
L5
Nicergoline
No Data
No Data
Noresthisterone
L3
Norfloxacin
hennadrine)
Obimin-az
No Data
probably compatible
Ofloxacin
L2
Omeprazole
potential toxicity
Oxytocin
Compatible
Penicillin G sodium
L2
Nifedipine
Norgesic(Paracetamol+Orp
Oxyphencyclimine
Paracetamal
Penicillin V
Perphenazine
Pethidine
Phenobarbital
Phenytion sodium
Piroxicam
No Data
B
B
C
B/D
D
D
C/D(3rd
trimester)
Podophylin
Poly - oph
No Data
L2
compatible
Limited human DataNo Data
Limited human DataNo Data

L1
L2
Compatible

L2
L2
compatible
No Data
11
Polytar Liquid
Potassium chloride
Prazosin 1 mg
Prednisolone
Premarin
Primaquin
Propanalol
No Data
No Data
Pregnancy Risk
Lactation Risk
Category
Category
compatible
C
C/D(1st trimester)
X
C
C/D(2nd and 3rd
L2
L5
compatible
Propylthiouracil
L2
Inhaler
No Data
Pyrazinamide
probably compatible
ifenesin)
L3
Quinine sulfate
L2
Rabies vaccine
Quibron(Theophylline+Gua
Ramipril
Ranitidine
compatible
C/D(2nd and 3rd
trimester)
compatible
potential toxicity
L2
Pyrazinamide
Limited human Data-
trimester)
PulmicortZBudesonide)
Limited human Data-
11
probably compatible
Rifampicin
Risedronate Na
Ritonavir
Roxithromycin
Salbutamal
Salmeterol+fulticasone
compatible
No Data
No Data
Senosides
Serrotio- peptidase
Simethicone
L2

L5
No Data
compatible
L3
compatible
Simvastatin
Contraindication
Sodium Bicarbonate
Sodium valproate
Compatible
Spironolacton
L2
L5
Simethicone+Pancreatin
Sitagliptine
Stavudine
No Data
B
Tenofovir
No Data
L2
Pregnancy Risk
Lactation Risk
Category
Category
Symbicort(Budesonide+for
moterol)
No Data
C
B
compatible
L5
11
Terbutaline so4
L2
Terramycin ointment
No data
Tetanus Toxiod
compatible
Thioridazine
No Data
No Data
No Data
Theophylline
Thyroxine sodium
Tolperisone
Tramadol
C
A
Triamcinolone 10mg
C/D(1st trimester)
Trihexyphenidyl HCL
Trospium Cl
Vitamine Bcomplex
A(RDA
recommened
L3
L1
compatible
compatible
compatible
dose)
L1 ;(L4 in high dose)
Vitamine C
A/C if dose
above RDA)
Vitamine k1
L1
compatible
Whitfield's Ointment
No data
Zidovudine
L5
Zoledronic acid
No Data
toxicity
No Data
11
No Data
No Data
1. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and Lactation.
8th ed. Lippincott Williams and Wilkins; 2008.
2. Lacy CF, Armstrong LL, Goldman MP, Lance LL. Drug Information
Handbook. 17 th edition. Hudson: Lexi-comp; 2008.
3. WHO. Breastfeeding and Maternal Medication Recommendations for

Drugs in the Eleventh WHO Model List of Essential Drugs. World
Health Organization 2002
11

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4- 5

3. systemic side effect

(U.S. Food and Drug

FDA Pregnancy Category

( milk to plasma ratio: M/P ratio )

Definitions of Lactation Recommendations(From Hale)

Category L3 (moderately safe) ;

Category L4 (possibly hazardous) ;

Pregnancy Category and Lactation Category

Limited human Datapotential toxicity

Limited human Datapotential toxicity

Limited human Data-

Limited human Datapotential toxicity

Limited human DataL3

Limited human Datapotential toxicity

Limited human Data-

Limited human Datapotential toxicity

L1; L3 early postnatal

Ferrous sulfate drop

Limited human Dataprobably compatible

Limited human Dataprobably compatible

Limited human DataGlipizide

Limited human Data-

Limited human Data-

Limited human Datapotential toxicity

Limited human DataL2

Limited human DataL5

Limited human Datapotential toxicity

C/D(2nd and 3rd

Limited human Data-

Limited human Data-

C/D(2nd and 3rd

Limited human Data-

C/D(2nd and 3rd

L1 ;(L4 if used first

Limited human Datapotential toxicity

Limited human Datapotential toxicity

Limited human Datapotential toxicity

Limited human DataNo Data

Limited human DataNo Data

Limited human Datapotential toxicity

Limited human DataL3

C/D(2nd and 3rd

Limited human Data-

Limited human Data-

Limited human Dataprobably compatible

Limited human Dataprobably compatible

L1 ;(L4 in high dose)

3. WHO. Breastfeeding and Maternal Medication Recommendations for

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