IV Drug Drip

1ml = 20 tetes =

Rumus Menghitung Tetes Infus

60 ugtt

1 ugtt/min = 1
MACRO = 1 cc = 20 tts/mnt
Tetes Infus Macro
ml/jam
tts/mnt = jmlh cairan X 20 / lama infus X 60
Lama Infus Macro
lama infus = (jmlh cairan X 20) / (tts/mnt X 60)

MICRO = 1 cc = 60 tts/mnt
Tetes Infus Micro
tts/mnt = (jmlh cairan X 60) / (lama Infus X 60)
Lama Infus Micro
lama infus = (jmlh cairan X 60) / (tts/mnt X 60)

Cardiac and Vasoactive drug

AntiArrhytmic drug

Class I agents interfere with the sodium (Na+) channel.

a.Na+ channel block (intermediate
association/dissociation), Affect QRS complex
Procainamide WPW
Quinidine alternative for recurrent AF

b.Na+ channel block (fast association/dissociation), DO

not affect QRS complex
Lidocaine Ventricular arrhythmia

Mexiletine not widely used

c.Na+ channel block (Slow association/dissociation)

Flecainide, propafenone prevent paroxysmal AF,
not widely used anymore

Class II agents are anti-sympathetic nervous system

agentBeta blockers.

Class III agents affect potassium (K+) efflux.

(Amiodarone, Sotalol, Ibutilide, Dofetilide)

Class IV agents affect calcium channels and the AV

node (Non dihydropirine CCB)

Class V agents work by other or unknown mechanisms.

(Adenosine, digoxine, MgSO4)
Diltiazem (Farmabes)drip 2,5
10mcg/kg/min

(1vial = 50mg)

Bolus 15 20mg IV lalu drip 10 mg/jam, titrasi

sampai maximal 15mg/jam
Amiodarone (Cordarone) 1mg/kg pada 6 jam
pertama lalu 0.5mg/kg, Max 2,2gr/d

(1

amp=150mg)
Bolus IV 150-300mg Then Drip 600 900mg + D5W
or NS 250ml x 24 jam

LidocaineBolus 50mg IV lalu drip

20Ug/kg/min (1-2mg/min)
Lidocaine 1 g + D5W 250ml x 24 jam

Pulmonary Edema
Nitroglycerine IV drip : 10 mcg/min, titration
by 5 mcg/min Q 15 20 mcg/min, then
gradually by 10 - 20 mcg/min, Max 100
mcg/min.(1amp = 10mg)
Nitroglycerine 20mg (2amp) + 50ml NS
Isosorbid dinitrate (Cedocard) drip
10mcg/mntatau 1 mg/jam, titrate 5mcgQ15,
Max 10 mg/jam
Cedocard 20mg (2amp) + 50ml NS mulai 2 ml/jam
(0.8mg/jam)

1ml = 0.4mg

Furosemide (Lasix) ;

(1 amp/2ml =

20mg)
Lasix 100mg /10ml (5 ampul) jalankan 1ml/jam
1ml = 10mg
Albumin 100cc 25%, dosis 4-6gr/hari

Hypertensive urgency
Nicardipine (Perdipine): 2.5 10 mcg/kg/min
atau 1-10mg/jam(1 amp = 10mg)
Perdipine 20mg + NS 50cc mulai 2ml/jam
(0.8mg/jam)

1ml = 0.4mg

Clonidine (Catapress)(1 amp = 150mg)

Catapress600mcg (4 amp) + 100ml NS mulai 5-20
ml/jam
Hydralazine (Aprezoline)(1 amp = 20mg)
Aprezoline 40mg (2amp) + 250ml NS mulai 520ml/jam

Ionotropic
Dobutamine drip (Dobuject/Dominic)

15 mcg/kg/min
Dobutamine 250mg + NS 50ml via syringe pump
SedianDobutamine 1 amp =
250mg
1amp =
250,000mcg
Syringe pump
menggunakanspuit 50ml
dengankecepatanpemberian
ml/jam atauugtt/min
maka 1 ml cairandalam

Dopamine drip5 20 mcg/kg/min

Dopamine 200mg + NS 50mlvia (syringe pump
50cc)
Sedian dopamine 1 amp =
200mg
1amp =
200,000mcg
Syringe pump
menggunakanspuit 50ml
dengankecepatanpemberian
ml/jam atauugtt/min
maka 1 ml cairandalam

Norepinephrine drip (Vascon)

0.1

1mcg/kg/min
Norepinephrine 8mg (2ampul) + NS 50ml via
syringe pump
Sedianvascon 2 amp = 8mg
2amp = 8,000mcg
Syringe pump
menggunakanspuit 50ml
dengankecepatanpemberian
ml/jam atauugtt/min
maka 1 ml cairandalam
syringe pump adalah 8,000

AntiTrombosis
Streptokinase dripStreptokinase 1.5 milion U +
NS 100 ml x 1 jam

AntiCoagulant
Heparin dripBolus 50 80U/kg (max 5000U),
lalu drip 18U/kg/jam (1000U/jam)
Heparin 10,000U + 200ml D5W (50U/ml) x 15-20
ugtt/min
Titrasi : APTT tiap 6 jam , normal 30-40dtk
APTT < 35 dtk (< 1.2 x kontrol) Naikkan infus
4U/kg/jam
35-45 dtk

(1.2 1.5 x kontrol) Naikkan infus

2U/kg/jam
46-70 dtk
71-90dtk
>90dtk

(1.5 2.5 x kontrol) Pertahankan

(2,5 3 x kontrol) Turunkan perlahan
( >3x control) Stop infus tunda

selama 4-6 jam

Pulmonary drug

Aminophyline drip(1 amp/10ml = 240mg)

drip dengan NS 1:1 ml
Bolus 6mg/kg lalu drip 0.3 1mg/kg/jam

; Max

1100mg/hari
Older patient

0,2 0.5mg/kg/jam ;

Max 500mg/hari
Aminofilin drip 480mg (2 amp) + NS 500ml
jalankan 15 20 ml/jam

1ml = 1mg

Terbutalin (Bricasma)0.1 6 mcg/kg/min(1

amp/5ml = 2.5mg)
Bricasma 5mg (2 amp) + NS 90ml mulai 5ml/jam
atau
Bricasma 5 amp + 250cc NS x 20cc/jam

Renal
MgSO4 drip 2.5 gram + NS 250ml jalan 6 jam
KCL drip50Meqdalam NS 500ml x 20 tts/min
Insulin drip100U hum R dalam 100cc NS Titrasi
2-4 ml/jam

(1ml = 1mg)

BS > 250 4U/jam,

BS 200-250 2U/jam,
BS < 200 1U/jam + D5NS 500 ml

Analgesic
Fentanyl dripjalan 25 50 mcg/jam
Pethidine drip200mg + Cedantron 8mg + NS
50mljalan 24 jam
Tramadol (+ ketamine) dripTramadol 200mg+
Ketamin 30mg jalan 24 jam

Neurology drug
Dexometamidine (Precedex) drip0.2
1mcg/kg/jam(1 amp/2ml = 200mcg)
Precedex bolus 50mcg lalu drip 200mcg + NS 50ml
jalan 2ml/jam, titrasi Q 15

(1ml = 4mcg)

Midazolam (Sedacum/Dormicum)
Dormicum 50-100mg + NS 250ml jalan 10 12
ugtt/min

(1ml = 0.2 0.4mg)

Nimodipine (Nimotop/Ceremax) drip

Nimotop 10mg + NS 50ml mulai 1-2mg/jam

(misal 2.1ml/jam)
Pentoxifyline (Trental) drip
Trental3 amp (total 900mg) + 500ml NS jalan 24
jam
Phenytoin (DIlantin) 10-15mg/kgbb loading
kecepatan 50mg/min

(1amp/2ml = 100mg)

IVIG (Gamaras)TOTAL DOSIS 2g/kg

dihabiskan 5 hari (0,4g/kg/hari selama 1-2
jam berturut turut)

(1vial = 0,5g atau 2,5gr)

Gastrointestinal
Somatostatin (Stilamin)
Stilamin 250mcg bolus lalu 3mg dalam 24 jam
(250mcg/jam)
Ocreotide(USP 1 vial = 50ug/ml)
Octreotide bolus 100 ug drip 25-50 ug /h
continous until bleeding stop

Pantoprazole / Esomeprazole/ Omeprazole

(1 amp = 40mg)
PPI 80mg + NS 100ml jalan 10cc/jam
1ml = 0.8mg
Lansoprazole (Prosogan)

(1 amp =

30mg)
Prosogan30mg + NS 100ml jalan 10cc/jam
= 0.6mg

1ml