Professional Documents
Culture Documents
Prize 2016
KNAPPILY
observed degradation of mitochondria and other intracellular structures within lysosomes of rat liver perfused
with the pancreatic hormone, glucagon.
The mechanism of glucagon-induced autophagy
in the liver is still not fully understood at the
molecular level. In recent years the scientific
world has rediscovered autophagy, with major
contributions to our molecular understanding and
appreciation of the physiological significance of
this process coming from numerous laboratories.
Although the importance of autophagy is well
recognized in mammalian systems, many of the
mechanistic breakthroughs in delineating how
autophagy is regulated and executed at the
molecular level have been made in yeast.
It wasnt easy to study yeast, primarily because their
cells were so small that a systematic study seemed
difficult. One mystery that remained was how the cell
ditched and recycled larger protein complexes and
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Japan.
He received a B.Sci. in 1967 and a D.Sci. in 1974,
both from the University of Tokyo.
As has been the case with many Nobel laureates,
even Ohsumi floundered at first, trying to find his
way.
He started out in chemistry but decided it was
too established a field with few opportunities.
So he switched to molecular biology. But his
Ph.D. thesis was unimpressive, and he could not
find a job.
His adviser suggested a postdoctoral position at
Rockefeller University in New York, where he was
to study in vitro fertilization in mice.
I grew very frustrated, he told the Journal of
Cell Biology in 2012. He switched to studying the
duplication of DNA in yeast.
That work led him to a junior professor position at
the University of Tokyo where he picked up a
microscope and started peering at sacks in yeast
where cell components are degraded work that
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of stress.
After infection, autophagy can eliminate invading
intracellular bacteria and viruses.
Autophagy contributes to embryo development and
cell differentiation. Cells also use autophagy to
eliminate damaged proteins and organelles, a
quality control mechanism that is critical for
counteracting the negative consequences of ageing.
Disrupted autophagy has been linked to
Parkinsons disease, type 2 diabetes and other
disorders that appear in the elderly. Mutations in
autophagy genes can cause genetic disease.
Disturbances in the autophagic machinery have
also been linked to cancer.
Intense research is now ongoing to develop drugs
that can target autophagy in various diseases.
Ohsumis experiments offered a peek into the
mysterious process of autophagy. The process
however is yet to be properly understood.
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between molecules.
Chemistry is inherently dynamic, so these forces
can hold molecules together strongly, but also
enforce softer attractions, which pull molecules
together, but still allow some degree of movement.
And it is these softer interactions that are key to
many molecular machines.
The machine has a track with two stations and a
shuttle that can slide along between them. The
shuttle cant escape from the end of the track
because there are bulky stopper groups at both
ends which it cant fit over.
The intermolecular forces that exist between the
shuttle and the different points on the track
determine where it sits.
Under normal conditions the shuttle doesnt have
much preference between the two stations, so it is
free to move rapidly over the polyether chain and
between the two ports.
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future.
One side of a contract may know more than the
other because of information asymmetry, so
insurance companies, for example, may end up
covering people with health problems rather than
the healthy, through what is called adverse
selection.
There are also agency problems as when
managers who are under contract with shareholders
actually try to maximize their own earnings rather
than those of their shareholders.
Contract theory helps us understand these problems.
And helps us solve them through better contract design.
Take a simple informal contract. An agitated
mother has to leave the house for a couple of
hours. She is worried her two children will bring
the house down by fighting over a large piece of
cake in the refrigerator.
The mother leaves a simple instruction the elder
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child will cut the cake while the younger one will
choose which piece to eat. Now, the elder child
cannot cheat. The mother has aligned their interests
or achieved incentive compatibility through
an informal contract.
Thus, their combined work helps us understand our
interactions with others and design better rules so
that social outcomes are better than before.
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prisons.
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Tagore.
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potential treasure.
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Blowin in the Wind and The Times Are aChangin which chronicled social unrest were
religiously chanted by anti-war and civil rights
movements. He earned an early reputation of
being more than a songwriter.
His six-minute single Like A Rolling Stone
expanded the range of popular music. Despite
criticism from the folk movement, his songs which
infused the style of rock music became runaway
hits.
His lyrics defied convention in every possible
sense and explored a vast range of themes
political, social, philosophical and literary.This
appealed to the counterculture movement.
He has been celebrated with every famous
award that recognizes and esteems genius and
continues to perform at the age of 75.
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A beautiful medal
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mind.
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