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(
) .
.
Drug Interaction
.
. .
.i
.ii
Pharmacokinetic Interaction
Pharmacodynamic Interaction
Sequential
:Mechanism of synergism*
inhibition of successive steps in
metabolism(TMP + Sulphonamides )
()
( )
()
()
()
()
()
()
()
-1
:
To broaden the spectrum of activity against
mixed infection.
( ) Mixed Infection
.
2
( . ) P.A.S.
- 3 ( Resistant
) Strains
( ) Drug Synergism
( ) 4 = 1 + 1
.
( ) Drug Addition ) ( 1 + 1 = 2
. ( Narrow
) Spectrum
.
( Broad Spectrum
) ( ) Drug Addition
( Drug
) Antagonism
.
-4
5
.
10
:
. Super infection. 1
Delay diagnosis. 2
Enhance selection of 3
resistant bacteria
. 4
11