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Florinef Fludrocortisone
Florinef Fludrocortisone
Florinef (fludrocortisones)
(GI) toxicity, including inflammation, bleeding, ulceration and
perforation, should be considered due to additive ulcerogenic
effects of these agents (especially aspirin) on the GI mucosa.
Grapefruit: Grapefruit juice may increase the plasma
concentrations of some orally administered drugs that are
substrates of the CYP450 3A4 isoenzyme. The proposed
mechanism is inhibition of CYP450 3A4-mediated first-pass
metabolism in the gut wall by certain compounds present in
grapefruits. The extent and clinical significance are unknown.
Moreover, pharmacokinetic alterations associated with
interactions involving grapefruit juice are often subject to a
high degree of interpatient variability.
Nursing Process- Assessment Assessment Evaluation
(Pre-administration assessment) Why would you hold or not give this med? Check after giving
Monitor blood pressure periodically during Abrupt cessation of this medication may cause Normalization of fluid and
therapy. Report significant changes. Hypotension patient to have addisonian crisis. Consult with electrolyte balance without the
may indicate insufficient dose. Monitor for fluid health care provider before withholding dose. development of hypokalemia or
retention (weight daily, assess for edema, and hypertension.
auscultate lungs for rales/crackles). Monitor
patients with Addisons disease closely and stop
treatment if a significant increase in weight or
blood pressure , edema, or cardiac enlargement
occurs. Patient with Addisons disease are more
sensitive to the action of fludrocortisones and may
have an exaggerated response.
Florinef (fludrocortisones)