Datasheet of SAG(Smo-Agonist)

Detailed information:
http://www.sun-shinechem.com/Details/SAG(Smo-Agonist)/1625/912545-86-9.html

USD250.0/50.0mg;
Price USD400.0/100.0mg
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Product Name SAG(Smo-Agonist)

3-chloro-N-((1r,4r)-4-(methylamino)cyclohexyl)-N-(3-(pyridin-4-
Chemical Name
yl)benzyl)benzo[b]thiophene-2-carboxamide

Synonyms SAG

CAS No. 912545-86-9 Catalog No 92802

Molecular Weight 490.06 O

N Cl
Molecular Formula C28H28ClN3OS S
N
NH
Other information N/A

Items Specifications Results

Appearance Off-white solid Complies

HNMR 400MHz,d6-DMSO Complies

Analysis
HPLC 98.0% Complies

Storage condition Kept under dry and cool condition

The above substance has been tested according to In house Standards, and it
Conclusion
meets requirements.

No.8 Rd, The Great Wall Park, Donghu High-Tech District 430074, Wuhan, China
Tel: 0086-27-59253327||Email:sales@sun-shinechem.com||Web:www.sun-shinechem.com
 SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM);
antagonizes Cyclopamine action at the Smo receptor. SAG potently activates the
Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM). Induces pathway
Description activation independently of Ptch proteins.

No.8 Rd, The Great Wall Park, Donghu High-Tech District 430074, Wuhan, China
Tel: 0086-27-59253327||Email:sales@sun-shinechem.com||Web:www.sun-shinechem.com