NAME_______________________________

VIROLOGY
TEST #3-sample2
R. H. REEVES
THE FIRST TWENTY QUESTIONS ARE WORTH TWO POINTS EACH. THERE IS
ONLY ONE CORRECT ANSWER. PLEASE CIRCLE THE CORRECT LETTER OR PLACE
THE CORRECT LETTER JUST TO THE LEFT OF THE QUESTION NUMBER.

1. VIRUSES WITH CIRCULAR VIRION GENOMES INCLUDE

A. HEPATITIS B VIRUS AND HERPES SIMPLEX VIRUS-1
B. SMALLPOX VIRUS AND PARVOVIRUS B19
C HUMAN PAPILLOMA VIRUS-16 AND HEPATITIS B VIRUS
D. SMALLPOX VIRUS AND AAV-2
E. SIMIAN VIRUS-40 AND HUMAN ADENOVIRUS-12

2. THESE VIRUSES HAVE A SINGLE ORF

A. AAV-2 & HUMAN PAPILLOMAVIRUS-16
B. HUMAN PAPILLOMAVIRUS-16 & HEPATITIS D VIRUS
C. HEPATITIS D VIRUS & TOBACCO NECROSIS SATELLITE VIRUS
D. TOBACCO NECROSIS SATELLITE VIRUS & PARVOVIRUS B19
E. PARVOVIRUS B19 & HEPATITIS D VIRUS

3. TRANSFER-RNA IS FOUND IN THE VIRION OF

A. POLYOMAVIRUS
B. HERPES SIMPLEX VIRUS
C MOLLUSCUM CONTAGIOSUM VIRUS
D. ROUS SARCOMA VIRUS
E. PARVOVIRUS B19

4. THE GENOME OF ADENOVIRUS-2

A. IS CIRCULARLY PERMUTED
B. HAS A Vpg ON EACH 3’-END
C. BOTH OF THE ABOVE
D. NEITHER OF THE ABOVE

5. ADENOVIRUSES
A. CAUSE WARTS
B. CAUSE ACUTE RESPIRATORY DISEASE
C. BOTH OF THE ABOVE
D. NEITHER OF THE ABOVE
6. IN ROUS SARCOMA VIRUS PROGRAMMED FRAMESHIFTING IS REQUIRED
FOR THE EXPRESSION OF
A. gag GENES
B. env GENES
C. BOTH OF THE ABOVE
D. NEITHER OF THE ABOVE

7. THESE TWO DNA VIRUSES DO NOT HAVE LIPID ENVELOPES

A. AAV-2 AND CYTOMEGALOVIRUS
B. SV-40 AND VACCINIA VIRUS
C. EPSTEIN-BARR VIRUS AND VARIOLA VIRUS
D. ADENOVIRUS-2 AND PARVOVIRUS B19
E. PAPILLOMAVIRUS AND MONKEYPOX VIRUS
8. LINEAR DNA IS FOUND IN THE VIRION OF
A. HEPATITIS D VIRUS
B. PAPILLOMAVIRUS
C SV-40
D. AAV-2
E. ROUS SARCOMA VIRUS

KEY FOR QUESTIONS 14-20. THERE IS ONLY ONE CORRECT ANSWER BUT
EACH KEY WORD MAY BE USED MORE THAN ONCE.

A. SMALLPOX VIRUS
B. POLYOMAVIRUS
C. PARVOVIRUS B19
D. EPSTEIN-BARR VIRUS
E. HUMAN PAPILLOMAVIRUS-16
F. HEPATITIS B VIRUS
G. HIV-1
I. HUMAN ADENOVIRUS-2

_____14. IT HAS A tat AND A rev GENE

_____15. HAS A "LOOSE-FITTING ENVELOPE" SURROUNDING ITS

ICOSAHEDRAL CORE

_____18. CONTAINS A WEDGED-SHAPED CORE

_____19. ITS DENATURED GENOME IS A SINGLE-STRANDED CIRCLE

VIRION NUCLEIC ACID

NUCLEIC ACID STRANDEDNESS FORM ENDS

HIV-1 _____ SINGLE _______ __________

VARIOLA V _____ ___________ LINEAR CROSS-LINKED, TRs

PARVOVIRUS DNA ___________ ________ ___________

HEPATITIS D V _____ ___________ ________ ___________

PAPILLOMAVIRUS _____ DOUBLE ________ ___________

21. DESCRIBE THE SIMILARITIES AND DIFFERENCES AMONG 1. RNA

VIRUSES, 2. RNA SATELITTE VIRUSES, 3.SATELLITE RNAs AND 4.
VIROIDS. BE SURE TO INCLUDE PROPERTIES SUCH AS REQUIREMENT FOR
HELPER VIRUS AND WHETHER THE RNA IS ENCAPSIDATED, AMONG OTHERS.
(A TABLE IS SUGGESTED.)

23. NAME THREE ENZYME ACTIVITIES ENCODED BY THE HIV-1 GENOME

(FOUR HAVE BEEN DETECTED). DESCRIBE THE MAIN FUNCTION OF
EACH AND AT WHAT PART OF THE HIV-1 LIFE CYCLE THEY ACT.
WHICH TWO ENZYMES ARE THE TARGETS FOR ANTI-RETROVIRAL DRUGS?