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    hoaivan5199351993
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    1. The document contains data from a drug excretion study measuring the amount of drug remaining (Xu) over time. 2. By plotting the natural log of the amount remaining versus time, the elimination rate constant (K) can be calculated from the slope. 3. Two methods are used, the area under the curve method results in a K of 0.248, while the rate of excretion method gives a K of 0.2584.

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    1. The document contains data from a drug excretion study measuring the amount of drug remaining (Xu) over time. 2. By plotting the natural log of the amount remaining versus time, the elimination rate constant (K) can be calculated from the slope. 3. Two methods are used, the area under the curve method results in a K of 0.248, while the rate of excretion method gives a K of 0.2584.

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    © All Rights Reserved
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    5 views2 pages

    Question 3

    Uploaded by

    hoaivan5199351993
    1. The document contains data from a drug excretion study measuring the amount of drug remaining (Xu) over time. 2. By plotting the natural log of the amount remaining versus time, the elimination rate constant (K) can be calculated from the slope. 3. Two methods are used, the area under the curve method results in a K of 0.248, while the rate of excretion method gives a K of 0.2584.

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    © All Rights Reserved
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    of 2

    Time Accumulative (Xu) Drug remain to be excreted (X0 - Xu) Ln (X0-Xu)

    2 190 310 5.7365723


    4 325 175 5.164786
    6 385 115 4.7449321
    7
    8 433 67 4.2046926
    10 460 40 3.6888795 6
    12 474 26 3.2580965 f(x) = - 0.24
    5
    Infinity 500 0 Err:502
    4
    from the graph, K = 0.248
    3
    intercept =6.2024 e^6.2024 = 493 = X0
    2

    0
    0 2 4

    Time average time Accumulative (Xu) dXu/dt Ln(dXu/dt)


    2 1 190 95 4.553876892
    4 3 325 67.5 4.212127598
    6 5 385 30 3.401197382
    8 7 433 24 3.17805383
    10 9 460 13.5 2.602689685
    12 11 474 7 1.945910149
    Infinity 500 #VALUE! #VALUE!

    from the graph, K = 0.2584


    Intercep = 4.8663 e^4.8663 = 129 = KX0 --> X0 = 500
    ARE method
    7

    6
    f(x) = - 0.2480048267x + 6.2023602885
    5

    0
    0 2 4 6 8 10 12 14

    Rate of excretion method


    5
    4.5
    f(x) = - 0.2584470143x + 4.8663246752
    4 R = 0.9848369556

    3.5
    3
    2.5
    2
    1.5
    1
    0.5
    0
    0 2 4 6 8 10 12

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