Professional Documents
Culture Documents
note that we do not secrete the ready enzyme because we would digest ourselves
when we have too much secretin: we can get a peptic ulcer - disrupting the alkaline mucous layer
Bacteria:
Heliobacter Pylori
HKATPase in Parietal Cells is responsible for acid secretion into the lumen
ACh (PNS)
Gastrin (G cells)
Antisecretagogues
prostaglandin
NE
CO2 and H2O are converted to HCO3
= HCl
Prilosec, Prevacid
Protein Digestion - HCl and Pepsin hydrolyze, denature and break down Proteins to peptides
Alkaline Tide
from Parietal cells. H+ across apical membrane, HCO3 across basolateral to blood (buffer blood)
Control of secretions
Cephalic phase
Gastric Phase
Intestinal Phase
Enterogastric reflex
Beta insulin
Alpha glucagon
Trypsinogen
Chemotrypsinogen
Pancreatic Amylase
Pancreatic Lipase