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  • Ps-Modeled Lamc Mutations Impair NMJ Development

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    The document discusses how mutations modeled after mutations found in patients with muscular dystrophy (PS-Modeled LamC Mutations) impair development of the neuromuscular junction (NMJ) in Drosophila larvae. Wild-type LamC expression leads to an increase in ghost boutons, but PS-Modeled LamC variants do not show this increase. Expression of specific PS-Modeled LamC variants, like LamC-E174K and LamC-r564c, in larvae also does not increase NMJ development compared to wild-type levels.

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    The document discusses how mutations modeled after mutations found in patients with muscular dystrophy (PS-Modeled LamC Mutations) impair development of the neuromuscular junction (NMJ) in Drosophila larvae. Wild-type LamC expression leads to an increase in ghost boutons, but PS-Modeled LamC variants do not show this increase. Expression of specific PS-Modeled LamC variants, like LamC-E174K and LamC-r564c, in larvae also does not increase NMJ development compared to wild-type levels.

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    7 views1 page

    Ps-Modeled Lamc Mutations Impair NMJ Development

    Uploaded by

    Scribd Lover
    The document discusses how mutations modeled after mutations found in patients with muscular dystrophy (PS-Modeled LamC Mutations) impair development of the neuromuscular junction (NMJ) in Drosophila larvae. Wild-type LamC expression leads to an increase in ghost boutons, but PS-Modeled LamC variants do not show this increase. Expression of specific PS-Modeled LamC variants, like LamC-E174K and LamC-r564c, in larvae also does not increase NMJ development compared to wild-type levels.

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    Abnormal NMJ

    development
    PS-Modeled LamC Mutations Lamc-WT - increase in ghost
    Impair NMJ Development boutons
    NE-budding inhibition

    Labeling of NMJs with


    Expression of PS-Modeled markers of presynaptic FISH LamC-E174K – no increase
    LamC variants in larva (anti-HRP) and
    postsynaptic (anti-DLG)

    LamC-r564c – no increase

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