Peptide synthesis technology with great potential

Introduction
Peptide synthesis is a solid phase synthesis process generally from the n-terminal (amino terminal) to the c-
terminal (carboxyl terminal) synthesis. In the past it was carried out in solution called liquid phase synthesis. in
1963, Merrifield proposed solid-phase peptide synthesis (SPPS). The process of synthesis was convenient, rapid so
that it became the preferred method and brought about a revolution of the peptides in organic synthesis. Afterwards
through continuous improvement and efforts, today solid-phase method has become a common technique in
peptide and protein synthesis while showing unparalleled advantages compared with the classic liquid phase
synthesis. For example, greatly reducing the difficulty of purifying product in each step.

The synthesis of cyclic peptides

Development
Nowadays, according to different requirements of customers, such as sequence, purity, molecular weight, etc.,
polypeptides can be processed and synthesized to meet these specific needs. This is custom peptide synthesis
which is a type of peptide synthesis service.
Customized synthesized peptide is crucial to a great number of fields，so let’s have a look .

Application Fields
Peptide synthesis service and custom peptide synthesis service mainly include these three aspects :

1. Peptide Synthesis
2. Peptide Modifications
3. Peptide Library Services

In fact, peptide synthesis service is much closer to our real-life situation than we imagined. Here are some
examples:
 Cancer immunotherapy Self-assembling peptide Peptide Venom Peptides

Peptide Natriuretic Peptides Neurodegenerative Disease Peptides Antimicrobial Peptides Milk-derived peptide therapies

Cancer immunotherapy: Cancer immunotherapy uses the body’s own immune system to attack cancer cells.
Peptide-based vaccines use tumor-associated antigens that associate with T cells to target cancer.
Self-assembling peptide: Self-assembling peptides are short, synthetic peptides characterized by amphipathic
sequences. These peptides are able to spontaneously self-assemble in aqueous solution to form highly organized
structures such as hydrogels.
Peptide Venom Peptides: Bioactive peptides are the most dominant component of animal venoms. Venom
peptides can vary in length and complexity, thus their synthesis requires a combination of chemical and
recombinant synthesis.
Peptide Natriuretic Peptides: Functioning in the induction of natriuresis, (the excretion of large amounts of
sodium in the urine), natriuretic peptides have been touted as useful biomarkers for the purpose of personalized
heart failure treatments and are involved in maintaining heart pressure and volume, as well as regulating
cardiovascular remodeling pathways.
Neurodegenerative Disease Peptides: A pathological hallmark of neurodegenerative diseases is the abnormal
aggregation of extracellular or intracellular peptides and proteins such as beta amyloid, tau, prions, and polyQ-
hHtt. Custom peptides can be used to study aggregation, and develop aggregative inhibitors and vaccines.
Antimicrobial Peptides: The prevalence of antibiotic-resistant microbes continues to hinder the treatment of a
variety of diseases. Custom peptides can be used to develop intelligently designed antimicrobial drugs
Milk-derived peptide therapies: Nutrition aside, milk has gained recognition as a rich source of potentially
therapeutic proteins and peptides that have a variety of functions, such as antimicrobial, antiviral, antioxidant,
immunostimulant, and anti-hypertension activities.
Summary
The development of semi-automatic and automatic peptide synthesizer has brought the technology of peptide
and protein synthesis to a peak. So far, people have achieved the synthesis of linear polypeptides composed of
hundreds of amino acids (or more) and the yield is quite high. As the exploration of the life phenomenon and
protein function becomes deeper and deeper, with the growing demand for a variety of functional materials, people
pay more attention to special shapes and features of peptides such as cyclic peptide, peptide, peptide sample
library, etc.