t (waktu) Cp (μg/ml) Log CP Ln Cp

0.50 0.42 -0.3768 -0.868

1.00 0.29 -0.5376 -1.238
1.50 0.22 -0.6576 -1.514
2.00 0.18 -0.7447 -1.715 profil kadar obat
2.50 0.15 -0.8239 -1.897
0.45
3.00 0.125 -0.9031 -2.079
4.00 0.096 -1.0177 -2.343 0.4

6.00 0.06 -1.2218 -2.813 0.35

8.00 0.038 -1.4202 -3.27 0.3
10.00 0.024 -1.6198 -3.73 0.25
0.2
0.15
t (waktu) Cp (μg/ml) Log CP Ln Cp
0.1
0.50 0.42 -0.3768 -0.868
1.00 0.29 -0.5376 -1.238 0.05

1.50 0.22 -0.6576 -1.514 0

0.1 1 10
2.00 0.18 -0.7447 -1.715
2.50 0.15 -0.8239 -1.897
3.00 0.125 -0.9031 -2.079 0
4.00 0.096 -1.0177 -2.343 0 2 4 6 8 10 12

6.00 0.06 -1.2218 -2.813 -0.2

8.00 0.038 -1.4202 -3.27 -0.4

10.00 0.024 -1.6198 -3.73
-0.6

-0.8

-1
t (waktu) Cp (μg/ml) Log CP Ln Cp
0.25 43 1.63347 3.761 -1.2
0.50 32 1.50515 3.466
-1.4
1.00 20 1.30103 2.996
1.50 14 1.14613 2.639 -1.6
2.00 11 1.04139 2.398
-1.8
4.00 6.5 0.81291 1.872
8.00 2.8 0.44716 1.03
12.00 1.2 0.07918 0.182
16.00 0.52 -0.284 -0.654

t (waktu) Cp (μg/ml) Cp-Cp' Log CP

0.50 0.42
1.00 0.29
1.50 0.22
2.00 0.18
2.50 0.15
3.00 0.125
4.00 0.096
 6.00 0.06
8.00 0.038
10.00 0.024

AUC
( μg/ml jam
t jam 0.5 1.0 1.5 2.0 3.0 4.0 6.0 8.0 10.0 12.0 )
iv 5.94 5.30 4.72 4.21 3.34 2.66 1.68 1.06 0.67 0.42 29.00
lrt oral 23.40 26.60 25.20 22.80 18.20 14.50 9.14 5.77 3.64 2.30 145.00
tablet 13.20 18.00 19.00 18.30 15.40 12.50 7.92 5.00 3.16 1.99 116.00
kapsul 18.70 21.30 20.10 18.20 14.60 11.60 7.31 4.61 2.19 1.83 116.00

t cp log cp
1 0.70 -0.15490196
2 1.20 0.079181246
3 1.40 0.1461280357
4 1.40 0.1461280357
6 1.10 0.0413926852
8 0.80 -0.096910013
10 0.60 -0.2218487496
12 0.50 -0.3010299957
16 0.30 -0.5228787453
T Cp Log Cp Eliminasi B,b
6 1.10 0.0413926852a = 0,379243
12 0.50 b= -0,056477
-0.3010299957
16 0.30 r= -0,9999969
-0.5228787453

1,4

Cp

50.00
45.00
40.00
35.00
30.00
Axis Title

25.00
20.00
15.00
10.00
5.00
0.00
 45.00
40.00
35.00
30.00

Axis Title
25.00
20.00
15.00
10.00
5.00
0.00
0.1

18.0
16.0
14.0
12.0
10.0
8.0
6.0
4.0
2.0
0.0
0.8 1
 Log CP
Log CP Li nea r (Log CP)
0
ar obat 0 2 4 6 8

-0.2

-0.3767507096
-0.4
-0.5376020021

-0.6 -0.6575773192
-0.7447274949
-0.8 -0.8239087409
Axis Title

-0.903089987

-1 -1.017728767

10
-1.2 -1.2218487496

-1.4 -1
8 10 12

-1.6

-1.8 Axis Title

t cp Cp - Cp' Log Cp
0.5 0.42 0.42-0.2=0.22 -0.657577
1.0 0.29 0.29-0.18=0.11 -0.958607
1.5 0.22 0.22-0.16=0.06 -1.221848

t cp Cp - Cp' Log Cp
6.0 0.06 -1.221846
8.0 0.0038 -1.420216
10.0 0.024 -1.619788
 Hub antara konsentrasi dan waktu setelah obat diinfuskan
Konsentrasi

(menit) Dalam Plasma (CSS – C)

( mcg / 100 ml )

10 23 28.8
20 35 16.8
30 42 9.8
40 48 3.8
50 50 1.8
60 51.8 0

t cp Cp-Cp' Log Cp-Cp' distribusi (A,a)

1 0.70 2,1 - 0,7=1,4 0.146128 a = 0,598455
2 1.20 1,85-1,2=0,65 -0.187086 b = -0.422549
3 1.40 1,6-1,4=0,2 -0.69897 r = -0.992632

t cp log cp
0.3 43.00 1.6334684556
0.5 32.00 1.5051499783
1.0 20.00 1.3010299957
1.5 14.00 1.1461280357
2.0 11.00 1.0413926852
4.0 6.50 0.8129133566
8.0 2.80 0.4471580313
12.0 1.20 0.079181246
16.0 0.50 -0.301029996

cp
50.00
45.00
40.00
35.00
30.00
Axis Title

25.00
20.00
15.00
10.00
5.00
0.00
 45.00
40.00
35.00
30.00

Axis Title
25.00
20.00
15.00
10.00
5.00
0.00
0.1 1.0 10.0 100.0
T

Chart Title
18.0
16.0
14.0
12.0
10.0
8.0
6.0
4.0
2.0
0.0
0.8 1 1.2 1.4 1.6 1.8 2
P
nea r (Log CP)
8 10 12

9987

-1.017728767

-1.2218487496

-1.4202164034

-1.6197887583

e
Reaksi orde Nol - dA / dt = ko
A= -kot + Ao atau
At = Ao – Ko.t
t½ = Ao / 2 ko
e = antiLn
C = Css [1 – e-0,693/ t ½ . n t½ ]
C = Css ( 1 – e -0,693 n ) = Css (1 – ( ½ )
n)
1 – (1/2)n

LD = Css.V
MD = Cl.Css
C = Css (1 – e –kt) infus diberikan
C = Css e –kt infus stop
C = Css ( 1 – e –kt )
C = Css - Css e –kt
In ( Css - C) = In Css – kt
K = Slope dari ln (Css – C) versus t
t 1/2 = 0.693 /k
Cl T = R/Css
R = ClT . Css
V = k.Cl

Do  Dma ks  Dmin
Do Do
Dmaks  
1  f 1  e  K
Do
Da v( ss ) 
K
Dma ks( ss )
C ma ks ( ss ) 
Vd
Dmin( ss )
C min ( ss ) 
Vd
Da v( ss )
C av( ss ) 
Vd