‫بسم هللا الرحمن الرحيم‬

Dermatology exam part one

12/2013
1) The skin compartments, dermis& epidermis are:

a. Independent functionally.
b. Develop from the same origin.
c. Have little anatomical difference.
d. Inter dependent functionally✅

2) Regarding cell differentiation the following factor affect its sequence:

a. Calcium concentration.
b. Protein kinas c.
c. Retinoic acid.
d. Expression of k1,k10✅
e. Interleukin 1.

3) Profilaggrin:

a. A large calcium binding glycoprotein.

b. Expressed in chromosome 1q21.✅
c. High calcium concentration result in its assembly.
d. Synthesized in spinous layer.
e. Contain 15-20 repetition of filaggrin.

4) Filaggrin:

a. Cationic protein rich in histamine.

b. Is a molecule that organizes intermediate filaments into
macromolecules✅ .
c. Disappear in the corneal layer.
d.
e.
5) The following cells are mesenchymal in origin:

a. Melanocytes
b. Merkls cells.
c. Langerhans cells.✅
d. Stem cells.
e. Keratinocytes.

6) periderm:

a. Highly differentiated cells.

b. Cells filled with glutamine.
c. It eventually shed out into the amniotic fluid as development
proceeds.✅
d. Its cells undergo apoptosis and disappear.

7) Spinous layer:

a. Found in the upper part of epidermis.

b. Have round cell nuclei.✅
c. Completely loses keratin 5 &14
d. Have fine and short keratin fibrils.

8) The skin layers in an embryo of 6 weeks:

a. Single layer of periderm.

b. Three layers.
c. Single layer of germenativum cell.
d. Two layers.✅

9) Which of the following regarding development is correct:

a. Desmosomal protein in 10 week.✅

b. Filaggrin in 12 wks.
c. Hair follicles in 15 wks.
d. Nail in 25 wks.
10) Which of the following is a component of sebum:

a. Phospholipids
b. Glycolipids.
c. Squalene.✅
d. Glycoprotein.

11) The antimicrobial effect of the skin can organized by:

a. Specific peptides.✅
b. Phospholipids.
c. Glycolipids.
d. Pyrolidon.
e. Carpoxyurocrnic acid.

12) In the Desmosomal junctions which of the following takes part:

a. Desmoglyins.
b. Desmocolins.
c. Desmoglyins & Desmocolins only.
d. Desmoplakins & desmoglyins.
e. Desmoglyins, Desmoplakins & Desmocolins.✅

13) In tight junction the following molecules are included:

a. Desmoglyins.
b. Catinins.
c. Claudins & ocludins✅
d. Connexons.

14) In alopecia areata the following feature is present:

a. Papules.
b. Itching
c. Exclamation mark hair.✅
d. Scales.

15) Regarding formation of corneal envelop:

 a. Organized by single compartment.
b. Organized by two compartments.
c. Purely organized by lipid devoid protein
corneocytes.
d. Lipids have no role in envelop formation.
e. Organized by 3 compartments.✅

16) Langerhans cells are:

a. Round in shape.
b. Localized in spinous layer.
c. Are pigmented cells.
d. Have granulated cytoplasm.✅

17) Regarding pigmentary cells:

a. They travel to epidermis as melanocytes.

b. Contain only one pigment.
c. Pigments are passed to other cells in
vesicular structure.✅
d. Pigments are passed to other cells through
osmoses

18) SPRP:

a. Have 5 subtypes.
b. Cross link with involucrine.
c. Synthesis stimulated with ultraviolet light.✅
d. SPRP3 is much expressed in vivo.
e. SPRP 2 is scanty in vivo.

19) Collagen:

a. Is formed of two chains.

b. Some are helical others are not.
c. Undergoes glycosylation before
expressed procollagen.✅
 d. Collagen 4 has staggered appearance.

20) Griseofulvin dosage is:

a. 2 mg /kg /day.
b. 100/kg /day.
c. 50/kg /day.
d. 20/kg /day.
e. 10/kg /day✅

21) The antilepromatous drug that has inflammatory action:

a. Dapsone.✅
b. Rifampecine.
c. Corticosteroids.
d. Clofazimine.
e. Tetracycline.

22) In sever dehydration the following are characteristic features except:

a. Lethargy.
b. Sunken eyes.
c. Absent tears.
d. Eager to drink.✅
e. Depressed anterior fontanel.

23) In addition to water what are important components of ORS (oral

rehydration salt) was for rehydration:

a. Bicarbonate & potassium.

b. Chloride & potassium.
c. Sodium & glucose.✅
d. Sodium & lactate.

24) Neurosyphills:

a. Dorsalispedis is a feature.
 b. Appears after 6 month from primary
chancer.
c. Are reversible.✅
d. Abscess formation.
e. Organism can be isolated from the
lesion.

25) Chancroid has:

a. Clean shallow erosion.

b. Deep dirty ulcer.
c. Shallow ulcer.✅
d. Discrete enlarged lymph node.

26) Gonorrheal urethritis best treated by:

a. Crystalline penicillin.
b. Procaine penicillin. ✅
c. Tetracycline.
d. Erythromycin.
e. Ciprofloxacin.

27) The main causative agent of non specific urethritis is:

a. Mycoplasma spp.
b. Staphylococcus.
c. Streptococcus.
d. Chlamydia trachomatis.✅
e. Niseria gonorrhea.

28) Bullous impetigo is caused by:

a. Streptococcus.
b. Staphylococcus.✅
c. Mycobacterium
d. Chlamydia.
29) Pimphigus is skin condition:

a. Caused by microbial infection.

b. Malignant form
c. Auto immune disease.✅

30) The following are STD except:

a. Scabies.
b. Molloscum contagiosum.
c. Syphilis.
d. Herpes simplex.
e. Gonorrhea.

31) The following are caused by dermatophytes except:

a. Favus.
b. Kerion.
c. Piedra.✅
d. T.capitis.
e. T.corporis

32) Regarding spermatozoa:

a. Are motile in seminiferous tubules.

b. Contain 46 chromosomes.
c. Contain enzymes in its head aids in
penetrating the ovum.✅
d. Stored in prostate.

33) Regarding dermis:

a. It is unlike epidermis doesn’t undergo

sequential differentiation. ✅
b. Structure & organization are not
predictable.
 c. Structure don’t undergo turnover in
normal conditions.
d. Remodeling occur only under
pathological process.

34) In Non Hodgkin’s lymphoma the following are true except:

a. Affect the lymph nodes.

b. Start in T cells.
c. Does not commonly extend to other
tissue.✅
d. The international WHO
classification is the latest classification.

35) The following cause generalized hyper pigmentation:

a. Xeroderma pigmintosa.
b. Tattooing.
c. Addison’s disease.✅
d. Crohn’s disease.

36) The following is best media to grow Chlamydia:

a. MC COY cells.✅
b. Treated ……. MC MOY cells.
c. Yolk sac of hen.
d. Chocolate agar.
e. Blood agar.

37) The following is true about gonad tumors’ except:

a. Seminoma is the most common type.

b. UN descended testis is prone to be
malignant.
c. Seminoma is radio resistant.✅
d. Presence of alfafeto protein.
38) In the stem cell cycle:

a. G1 is greatly variable in duration.✅

b. S phase takes from 4-6 hrs.
c. G0 is constant in the cycle.
d. G2 takes from 10-12 hrs.

39) In eccrine sweat gland:

a. The secretory part contain 2 layers one

clear cell secrete water & electrolyte &
other larger of dark cells.
b. The intraepidermal part is known as
acrosyringium.✅

40) Concerning allergic dermatitis in children it start at the age of:

a. 3 days.
b. 3 months.
c. 3 years.
d. 5 years.✅
e. 10 years.

41) Multiple Myeloma all are true except:

a. There is a monoclonal raise in the

immunoglobulin electrophoresis.
b. IGA the highest immunoglobulin.✅
c. One of the most aggressive tumors.

42) The following are glycoproteins except:

a. Laminin
b. Vitronictin.
c. Tinacin
d. Thrombospondin
e. Syndican.✅
43) The following are used in treatment of acne except:

a. Dapsone.
b. Retinoic acid.
c. Anti androgens.
d. Steroids.✅
e. Tetracycline.

44) The following is true about erector Pilli muscle:

a. Appear from the lateral wall to the hair canal.

b. Aids in thermoregulation.✅
c. Contract in high temperature.
d. Connected to the basement membrane.
e. Support the sebaceous gland.

45) Apocrine gland:

a. Found in palms & soles.

b. The glands secreting milk is one of forms.✅
c. Develop in second month.
d. Sweat contains water, glucose & electrolyte.

46) Regarding hair follicle:

a. Villous hair contains medulla.

b. Terminal hair grows vertically.
c. The order of layer from inside to out side is (cortex
,medulla ,Huxley ,inner rout & outer rout sheath)
d. The inner rout sheath melanocytes.
e. Differentiation & keratinization continue till the
end of hair shaft.✅

47) Proteoglycan & gags:

a. Have specific core protein in proteoglycans.✅

b. Hold till 2000 of it weight water.
 c. Are small molecules.
d. Consist 2% of the dermal molecules.
e. Are present in small amounts in the dermis.

48) Epidermal barrier:

a. Is purely mechanical barrier.

b. Soluble substances penetrate easily.
c. Water is slightly permeable.✅
d. Highly permeable for covalent substance.

49) Psorriasis is considered as systemic disease the most common system

involved with skin:

a. Articular system.✅
b. Respiratory system.
c. GIT
d. Urinary system.
e. Nervous system.

50) Best treatment for tinia capitis is:

a. Ketoconazole.
b. Topical antifungal.
c. Itraconazol.
d. Metronidazole.
e. Griseofulvin.✅

51) Which of the following is immune localized to basement membrane:

a. Entacitin.✅
b. Plectin.
c. Heparan.
d. Collagen 1.
e. Collagen 9.

52) Regarding papillary dermis:

 a. Contain elunin elastic fibers.
b. Have large collagenous fibers.
c. Blood capillaries pass in couples to each dermal
papilla.
d. Transfer cytokines & growth factors to the epidermis.✅

53) Adherent junctions:

a. Connect neighboring cells.✅

b. Decrease in number with age.
c. Density is affected by the body site & sex.
d. Is the major type of junction in skin

54) The up words movement of differentiating cells from the basal layer is
depend on:

a. Crowding of the newly formed mitotic cells.

b. Damage of the desmosomes & hemidesmosome.
c. Down regulation of Þ6ß4 integrins.✅
d. Cytokines guard the movement.
e. Growth factors controls movement.

55) Subcutaneous tissue:

a. Is absents in & female genitalia.

b. Lipocytes develop in the 20th week.
c. Some premature as macrophage.
d. Adipocytes stores but not produce fats.
e. ✅

56) Brown fats:

a. Mainly found in the retroperitoneal area.

b. Produce interleukin 1.✅
c. Are less active than white fat.
d. Is mono loculated.
e. Have no mitochondria.
57) Dermis:

a. Form 40% of bulk of skin.

b. Is completely tensile but restricted pliability.
c. Lymphocytes & plasma cells are not found usually in
normal skin.
d. Proteoglycans & gags are the only ground substance.✅

58) The main lipid component in the corneal envelop is:

a. Phospholipids.
b. Cholesterol.
c. Ceramides.✅
d. Triglycerides.
e. Free fatty acids.

59) In the DEJ which of the following is true:

a. Anchoring filaments connect the LD to the upper

dermis.
b. Laminin 5& 6 is the major component of lamina
Lucida.✅
c.
d.