Diagram showing the main modes of action of drugs used in

peptic ulcer

2 Blood vessel
∅ MAST CELL
M1R GR
Parasympathetic NSAIDs
nerve
Gastrin ∅
ACh

Histamine PGE2 AA
1
∅ 5
M1R H2R GR

HCO3- PGR PGR

MUCOUS
HCO3 -
H2CO3 ∅ ⊕ CELL
A HCO3-
⊕
Cl- CO2 H2O
- +
Cl K H+

PARIETAL CELL
S P
∅
2
∅
- + +
Cl K H 3

HCl ∅
4

LEGEND:
GR gastrin receptor
H2R histamine receptor type 2 Drugs used in peptic ulcer:
M1R muscarinic receptor type 1 1. H2 receptor antagonists
P proton pump 2. Proton pump inhibitors
S symport carrier for K+ and Cl- 3. Anti-Helicobacter agents
A antiport carrier for HCO3- and Cl- 4. Antacids
PGE2 prostaglandin E2 5. Prostaglandin analogues
AA arachidonic acid
NSAIDs non-steroidal anti-inflammatory drugs
PGR prostaglandin receptor

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