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  • Guidelines For Use of Cephalexin (Keflex) : Recommended Neonatal Dose, Route, and Interval

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    Ita Burhamzah
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    This document provides guidelines for using the antibiotic cephalexin (Keflex) in neonates. It recommends doses of 25-50 mg/kg/day divided every 6-8 hours for infections, and 25 mg/kg/day divided twice daily for urinary tract infection prophylaxis. Cephalexin is a first-generation cephalosporin effective against many gram-positive and some gram-negative bacteria, useful for skin/soft tissue infections and UTIs. Adverse reactions may include hypersensitivity. Use caution in renal insufficiency and do not use in patients with immediate penicillin allergy. Administer doses on an empty stomach or with food if upset occurs, and adjust dose for renal

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    Cephalxin Keflex

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    This document provides guidelines for using the antibiotic cephalexin (Keflex) in neonates. It recommends doses of 25-50 mg/kg/day divided every 6-8 hours for infections, and 25 mg/kg/day divided twice daily for urinary tract infection prophylaxis. Cephalexin is a first-generation cephalosporin effective against many gram-positive and some gram-negative bacteria, useful for skin/soft tissue infections and UTIs. Adverse reactions may include hypersensitivity. Use caution in renal insufficiency and do not use in patients with immediate penicillin allergy. Administer doses on an empty stomach or with food if upset occurs, and adjust dose for renal

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    © All Rights Reserved
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    14 views1 page

    Guidelines For Use of Cephalexin (Keflex) : Recommended Neonatal Dose, Route, and Interval

    Uploaded by

    Ita Burhamzah
    This document provides guidelines for using the antibiotic cephalexin (Keflex) in neonates. It recommends doses of 25-50 mg/kg/day divided every 6-8 hours for infections, and 25 mg/kg/day divided twice daily for urinary tract infection prophylaxis. Cephalexin is a first-generation cephalosporin effective against many gram-positive and some gram-negative bacteria, useful for skin/soft tissue infections and UTIs. Adverse reactions may include hypersensitivity. Use caution in renal insufficiency and do not use in patients with immediate penicillin allergy. Administer doses on an empty stomach or with food if upset occurs, and adjust dose for renal

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    Guidelines for Use of Cephalexin (Keflex))

    Recommended Neonatal Dose, Route, and Interval

    25 - 50 mg/kg/day PO divided Q 6-8 hr.

    UTI prophylaxis - 25 mg/kg/day PO divided BID

    Chief Indications

    1. First generation cephalosporin - bactericidal against many gram-positive and a few gram-
    negative organisms
    2. Skin and soft tissue infections, impetigo neonatorum
    3. Urinary tract infection prophylaxis

    Possible Adverse Reactions

    1. Hypersensitivity (anaphylaxis)

    CONTRAINDICATIONS/PRECAUTIONS:

    1. Use with caution in renal insufficiency


    2. Should not be used in patients with an immediate hypersensitivity to penicillin -
    approximately 5 - 15% of penicillin-allergic patients will also be allergic to cephalosporins

    Nursing Implications

    1. Administer doses on an empty stomach; 2 hours before or 1 hour after meals, but may
    administer with food if stomach upset occurs

    Special Considerations and Calculations

    1. Adjust dose in renal failure

    References:
    1. Pediatric Dosage Handbook , 17th Edition, 2010-2011

    Reviewed/Revised: 3/2011 by

    Samir Alabsi, MD
    Kelli Cunningham, Pharm. D, BCPS
    Rebecca Willson, ARNP, NNP

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