TAGUM DOCTORS COLLEGE INC.

Mahogany St., Rabe Subdivision Tagum City

Bachelor of Science in Nursing

DRUG STUDY
Name of Student : Sian, Liza P. – BSN3, Group 1
Name of Client : Paradiang, Clinton Age: 9 y.o. Sex: Male Rating:
Date of assessment: Sept. 13, 2018 Physician: Dr. Lagmay Status:
Chief complaint : Fever Admitting diagnosis: SVI r/o Dengue fever

Date Image of Drug Name of Drug Classification Dosage/ Mechanism of Action

Time/Route
Sep. 11, Brand name: antiinfective; 750mg, Q8, Ampicillin inhibits bacterial cell wall synthesis by
2018 Ampicillin antibiotic; IVTT binding to 1 or more of the penicillin-binding proteins
Sodium aminopenicillin (PBPs) which in turn inhibit the final transpeptidation
step of peptidoglycan synthesis in bacterial cell walls.
Generic name: Bacteria eventually lyse due to ongoing activity of
Ampicillin cell wall autolytic enzymes (autolysins and murein
Omnipen hydrolases) while cell wall assembly is arrested.
Pharmacology:
Pharmacokinetics
Absorption: Moderately well absorbed from the GI
tract (50%). Food may reduce rate and extent of
absorption. Time to peak plasma concentration:
Approx 1-2 hr.
Distribution
Widely distributed. Crosses the placenta and enters
breast milk (small amounts). Plasma protein binding:
Approx 20%.
Metabolism
Metabolised to some extent to penicilloic acid.
Excretion
Via urine as unchanged drug (oral: approx 20-40%;
parenteral: approx 60-80%) w/in 6 hr and faeces
(small amounts). Plasma half-life: Approx 1-1.5 hr.
 Indication
Supplement in systemic
therapy for treatment of
susceptible infections,
Meningitis, Intrapartum
prophylaxis against group B
Streptoccocal infection in
neonates
Reference: www.rnpedia.com
Contraindications Adverse Reaction
Contraindicated to CNS:
patients with Lethargy hallucinations,
allergies to seizures
penicillin's, CV:
cephalosporin's, or CHF
other allergens GI:
Glossitis, stomatitis,
gastritis, sore mouth,
furry tongue, black "hairy"
tongue, nausea, vomiting,
diarrhea, abdominal pain
GU:
Nephritis
Hematologic:
Anemia,
thrombocytopenia,
leukaemia, neutropenia
Local:
Pain, phlebitis,
thrombosis at injection
site
Other:
Superinfections- oral and
rectal moniliasis
Nursing Responsibilities
1. Assess for allergies to penicillin cephaloporins, or other
allergens and renal disorder.
2. Culture infected area before treatment; reculture area if
respose is not as expected.
3. Check IV site carefully for signs of thrombosis or drug
reaction.
4. Inform patient that ampicillin contain inactive
ingredients, which can cause allergic reactions or other
problems.
5. Teach patient to report pain or discomfort at sites,
unusual bleeding or bruising, mouth sores, rash, hives,
fever, itching, sever diarrhea, difficulty of breathing.
6. Ampicillin may cause live bacterial vaccines (such as
typhoid vaccine) to not work as well. Do not have any
immunizations/vaccinations while using this medication.
7. Store between 20-25°C (discard after 14 days).
8. Precaution to patient w/ history of β-lactam allergy.
Renal impairment. Pregnancy and lactation.
9. Monitor renal, hepatic, and haematologic function
periodically; observe signs and symptoms of
anaphylaxis during 1st dose.