EUGENOL

Biological source: Eugenol is found in a variety of plants including clove buds, cinnamon bark
and leaves, tulsi leaves, turmeric, pepper, ginger, oregano and thyme. In addition, several other
aromatic herbs including basil, bay, marjoram, mace and nutmeg are also claimed to have significant
quantity of eugenol.(1)

Pharmacological action: Eugenol, the major constituent of clove oil, has been widely
used for its anesthetic and analgesic action in dentistry. Eugenol exhibits pharmacological
effects on almost all systems and our aim is to review the research work that has identified
these pharmacological actions. Eugenol possesses significant antioxidant, anti-inflammatory
and cardiovascular properties, in addition to analgesic and local anesthetic activity. The
metabolism and pharmacokinetics of the compound in humans have been studied. Eugenol has
also been used as a penetration enhancer. The compound is a very promising candidate for
versatile applications, and the design of new drugs based on the pharmacological effects of
eugenol could be beneficial.(2)

Dose and marketing brands (3)

NAME DOSAGE STRENGTH

Baby Orajel Naturals Remedy for Teething Pain Relief Gel 12 mg/1g

DenTek Eugenol Liquid 850 mg/1mL

Eugenol Liquid 100 %

Eugenol Liquid 850 mg/1mL

Eugenol Toothache Medication Liquid 850 mg/1mL

Eugenol Toothache Medication Liquid 850 mg/1mL

Nuby Teething Gel Gel 13 mg/1g

Nuby Teething Gel Gel 8 mg/1g

Orajel Naturals FAst Relief for Gel 12 mg/1g

Teething Pain

Red Cross Toothache Liquid 850 mg/1mL

Walgreens Natural eugenol/ Liquid 850 mg/1mL

Toothache medication with
Cotton pellets and tweezers
Adverse effect:
*Eugenol is hepatotoxic, meaning it may cause damage to the liver.(4) --------
*overdose is possible, causing a wide range of symptoms from blood in the patient's urine,
to convulsions, diarrhoea, nausea, unconsciousness, dizziness, or rapid heartbeat.(5)
*When eugenol is used in dental preparations such as surgical pastes, dental packing,
and dental cement, it may cause contact stomatitis and allergic cheilitis.(6)

Reference:
(1)M. K. Yadav, S. W. Chae, G. J. Im, J. W. Chung and J. J. Song,

Eugenol: a phyto-compound effective against methicillin resistant and methicillin-sensitive

Staphylococcus aureus clinical strain bio lms, PLoS One, 2015, 10, e0119564.

(2)Eugenol: a natural compound with versatile pharmacological actions.

Nat Prod Commun. 2010; 5(12):1999-2006 (ISSN: 1934-578X)

Pramod K; Ansari SH; Ali J

(3) Drug bank

(4) ] Thompson, D. C.; Barhoumi, R.; Burghardt, R. C. (1998). "Comparative toxicity of eugenol and its
quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays". Toxicology and
Applied Pharmacology. 149 (1): 55–63.doi:10.1006/taap.1997.8348. PMID 9512727.

(5) "Eugenol Oil Overdose" The new York Times

(6) Schmalz, Gottfried; Bindslev, Dorthe Arenholt (2008-10-10). Biocompatibility of Dental

Materials.ISBN 9783540777823. Retrieved 2014-04-27.