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TABLET PRESS ES
Multi-Layer, MUPS, Direct Compression
Rieckermann OSD Seminar 2018
P R E S E N TAT I O N O U T L I N E
KORSCH AG
KORSCH
America Inc.
KORSCH
Asia Pacific
INNOVATION CENTER AT A GLANCE
1 XL 400 MFP
XL 400 MFP
▪ Flexible Single and Multi-
Flexible High-Speed Layer, High-Speed
Single & Multi-Layer Production
Production
2 XL 4004 MFP
▪ Flexible Single and Multi-
Layer, High-Speed
XL 4004 MFP
Production
Flexible High-Speed ▪ Highly Compact
Single & Multi-Layer
Production
Highly Compact
C O M M O N P L AT F O R M F O R E N H A N C E D C O M PAT I B I L I T Y
Through-The-Wall Installation
SERVICE CONVENIENCE
▪ Machine Base:
□ Large access doors
□ Central connection for peripherals
□ Free of main drive, lube pump,
and major components
▪ Multi-Function Column
□ Superior access to major
components in the Multi-Function
Column for simplified
maintenance
MINIMAL NOISE AND VIBRATION
▪ Layer 1:
□ 2-chamber feeder
□ 5 kN tamping station
▪ Layer 2:
□ 2-chamber feeder (retracting)
▪ 100 kN main compression
B I - L AY E R M O D E 2 . 2
▪ Layer 1:
□ 2-chamber feeder
□ 5 kN tamping
▪ Layer 2:
□ 1-chamber feeder (retracting)
▪ 20 kN precompression
▪ 100 kN main compression
B I - L AY E R M O D E 2 . 3
▪ Layer 1:
□ 1-chamber feeder
□ 5 kN tamping
▪ Layer 2:
□ 2-chamber feeder (retracting)
▪ 20 kN precompression
▪ 100 kN main compression
B I - L AY E R M O D E 2 . 4
▪ Layer 1:
□ 1-chamber feeder
□ 5 kN tamping
▪ Layer 2:
□ 1-chamber feeder (retracting)
▪ 100 kN precompression
▪ 100 kN main compression
T R I - L AY E R
MODES
T R I - L AY E R M O D E 3 . 1
▪ Layer 1:
□ 1-chamber feeder
□ 5 kN tamping
▪ Layer 2:
□ 1-chamber feeder (retracting)
□ 5 kN tamping
▪ Layer 3:
□ 1-chamber feeder (retracting)
▪ 100 kN main compression
PROCESS ADVANTAGES
Multi-Layer Modes
O P T I M A L L AY E R S E PA R AT I O N
▪ No cross-contamination:
□ No product re-circulation
□ Zero clearance feeders: seal
between feeder and die table
□ Dust extraction before each
feeder
▪ Tamping (low compression force)
to obtain an even surface and the
filling space for the next layer
□ Avoids layer separation
FEEDER BASE
Flexible
Feeder Seal Feeder
Drives
F O R C E F E E D E R M AT E R I A L C O N TA I N M E N T
PTFE Sealing
Plate
F U L LY A U T O M AT E D L AY E R S A M P L I N G
▪ Independent weight control of every layer for correct drug delivery profile
▪ Press force control system:
□ Monitoring of individual force at the tamping and final compression stations
□ Closed loop control of each layer weight
▪ Single tablet rejection based on layer tamping force and final compression
force with reject log
QUICK CHANGE OVER BETWEEN THE DIFFERENT
C O N F I G U R AT I O N S
Direct Placement
IEM Placement in Active Tablet
XL 400 MFP with IEM Module
Indirect Placement
IEM Placement in Placebo Tablet
Placement of Placebo Tablet Core in
Final Active Tablet
XL 400 MFP with IEM Module
XL 400 MFP with 2C Module
MIC R OC H IP -IN -TABLET TEC H N OLOGY
SYSTEM COMPONENTS
MUPS Design:
MUPS
(MULTIPLE UNIT PELLET(PARTICULATE) SYSTEM)
MUPS Design:
MUPS
(MULTIPLE UNIT PELLET(PARTICULATE) SYSTEM)
MUPS
(MULTIPLE UNIT PELLET (PARTICULATE) SYSTEM)
• Particle Damage
Solution:
Design Factors:
DIRECT COMPRESSION
• Insufficent Hardness
Flexible
Feeder Seal Feeder
Drives
F O R C E F E E D E R M AT E R I A L C O N TA I N M E N T
PTFE Sealing
Plate
EXTENDED DWELL TIME (VERSION 1.1)