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  • Parasympatholytics Classification and Uses

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    Amit Kochhar
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    The document discusses parasympatholytics, which are drugs that block the effects of acetylcholine in the parasympathetic nervous system. It divides parasympatholytics into two main classifications: muscarinic receptor antagonists and ganglion blocking agents. Muscarinic receptor antagonists are further divided into natural alkaloids like atropine, semisynthetic derivatives, and synthetic compounds that act as mydriatics, antisecretory agents, or antiparkinsonian drugs. Ganglion blocking agents are competitive or persistent depolarizing blockers and include compounds like hexamethonium or nicotine in large doses. Finally, the document lists some common uses of parasympatholytics such as for pre

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    Classification of parasympatholytic drugs.

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    Parasympatholytic

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    The document discusses parasympatholytics, which are drugs that block the effects of acetylcholine in the parasympathetic nervous system. It divides parasympatholytics into two main classifications: muscarinic receptor antagonists and ganglion blocking agents. Muscarinic receptor antagonists are further divided into natural alkaloids like atropine, semisynthetic derivatives, and synthetic compounds that act as mydriatics, antisecretory agents, or antiparkinsonian drugs. Ganglion blocking agents are competitive or persistent depolarizing blockers and include compounds like hexamethonium or nicotine in large doses. Finally, the document lists some common uses of parasympatholytics such as for pre

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    59 views3 pages

    Parasympatholytics Classification and Uses

    Uploaded by

    Amit Kochhar
    The document discusses parasympatholytics, which are drugs that block the effects of acetylcholine in the parasympathetic nervous system. It divides parasympatholytics into two main classifications: muscarinic receptor antagonists and ganglion blocking agents. Muscarinic receptor antagonists are further divided into natural alkaloids like atropine, semisynthetic derivatives, and synthetic compounds that act as mydriatics, antisecretory agents, or antiparkinsonian drugs. Ganglion blocking agents are competitive or persistent depolarizing blockers and include compounds like hexamethonium or nicotine in large doses. Finally, the document lists some common uses of parasympatholytics such as for pre

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    of 3

    http://www.gpatonline.

    com Pharmacology ANS: Parasympatholytics

    Cholinergic System: Parasympatholytics

    Classification:
    A. Muscarininc Receptors antagonist:
    1. Natural Alkaloids
    Atropine, Hyoscine (Scopalamine)
    2. Semisynthetic derivatives
    Homatropine, Hyoscine butyl bromide, Ipratropium bromide, Tiotropium bromide
    3. Synthetic Compounds
    a. Mydriatics:
    Cyclopentolate, Tropicamide
    b. Antisecretory – Antispasmodic:
    I. Quaerternary compound : Propantheline, oxyphenonium, Clidinium,
    Pipenzolate methyl bromide, Isopropamide,
    Glycopyrolate
    II. Tertiary amines Dicyclomine, Oxybutynin, Flevoxate,
    Pirenzepine, Telenzepine.
    c. Antiparkinsonian
    Trihexyphenidyl, Procyclidine, Biperiden, Benztropine, Cycrimine,
    Ethopropazine
    B. Ganglion blocking agents:
    1. Competitive blockers
    Quaerternary ammonium compounds : Hexamethonium, Pentolinium
    Secondary / tertiary blockers : Mecamylamine, Pempidine
    Monosulfonium compounds : Trimethophan comforsulfonate
    2. Persistent depolarizing blockers
    Nicotine (Large dose), Anticholinestrases (large doses)

    Atropine Hyoscine

    Homatropine Hyoscine butyl bromide

    Tech Sanskar eLearning Solutions http://www.gpatonline.com Page 1 of 3


    http://www.gpatonline.com Pharmacology ANS: Parasympatholytics

    Ipratropium bromide Tiotropium bromide

    Tropicamide
    Cyclopentolate

    oxyphenonium
    Propantheline

    Isopropamide Dicyclomine

    Pirenzepine Trihexyphenidyl

    Procyclidine
    Biperiden

    Tech Sanskar eLearning Solutions http://www.gpatonline.com Page 2 of 3


    http://www.gpatonline.com Pharmacology ANS: Parasympatholytics

    Benztropine
    Ethopropazine

    Uses:
     As antisecretory – Preaneashetic medication, Pulmanary embolism, P0065ptic ulcer
     As antispasmodic
     Bronchial asthma, Bronchitis, COPD.
     As mydriatics and cycloplegic
     Parkinsonism
     Motion sickness

    Tech Sanskar eLearning Solutions http://www.gpatonline.com Page 3 of 3

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