01‐Aug‐19

BACKGROUND
1. Alzheimer’s disease (AD) is a progressive neurodegenerative disease and a
DESIGN AND DEVELOPMENT OF ALZHEIMER DISEASE DETECTION
EQUIPMENT USING ELECTROENCEPHALOGRAPHY
growing public health concern. At the cognitive level, Alzheimer is mainly
characterized by memory impairment but it also affects other cognitive
ZAINURRAHMAN WAHYU RIANTO domains.
1110151040 2. In 2050, predicted the number of patients will increase threefold. In Indonesia
from several sources say the number of Alzheimer's patients in Indonesia
Advisor:
currently reaches 1 million people.
Ir. Kemalasari M.T
NIP. 19630314.200003.2.001 3. Utilization of neurological technology in detecting Alzheimer's disease from
MRI, PET, CT, and SPECT. But it is all radiative, so genetic mutations can
Paulus Susetyo W. S.T., M.T. occur and worsen Alzheimer's patients. Therefore using EEG to detect
NIP. 19700410.199603.1.002 Alzheimer's becomes the solution.

PURPOSE FINAL PROJECT PROBLEM STATEMENT

1. Make brain signal filters using Low Pass Filter Order 3 40Hz and
Able to classify and identify Alzheimer's disease using the Fast High Pass Filter 0.16Hz
Fourier Transform method and Backpropagation Neural Network
2. Processing brain signal data to get alpha signals using Fast
so that it can be more quickly and precisely diagnosed with
Fourier Transform.
Alzheimer's disease.
3. Perform brain signal calcification to find out whether someone is
Alzheimer's or not by comparing Alzheimer's EEG data that has
been processed using Fast Fourier Transform.

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PROBLEM LIMITATION SYSTEM WORKFLOW

1. Target examination of people aged between 45-70 years.
2. Using the Ardunio UNO microcontroller.
3. Using 6 electrodes (3 left, 3 right) and placing them on thin hair (almost
bald).
4. Laying electrodes in the position of the parietal, occipital, and temporal
brain.
5. Using alpha brain signals (8-13Hz).
6. Measurement of brain signals is done in a state of sitting and relaxing with
eyes closed in a state of wakefulness not to fall asleep with a duration of
5-10 minutes.

HARDWARE DESIGN HARDWARE DESIGN

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HARDWARE TESTING PROCEDURE RESULTS OF HARDWARE TESTING

Amplifier Circuit Testing
Calculation
Function
Result Measured Error Average
Generator Error (%)
Voltage Voltage (mV) (%)
Voltage (uV)
(mV)
5 1,796 1,816 1.10132
25 8,980 8,998 0.20004
45 16,164 16,187 0.14208
65 23,348 23,385 0.15822
85 30,532 30,578 0.15043
105 37,716 37,755 0.10329 0.271049
125 44,901 45,132 0.51183
145 52,084 52,145 0.11698
165 59,268 59,342 0.12470
185 66,452 66,553 0.15175
210 75,432 75,599 0.22090

RESULTS OF HARDWARE TESTING DATA ACQUISITION

Testing of Order 3 LPF Series
Frequency
Function
Measured frequency (Hz) Error (%) Error Average (%)
Generator
(Hz)
5 4,981 0,380
10 10,156 1,560
15 15,142 0,946
20 19,978 0,110
25 25,415 1,660
0,8282
30 29,845 0,516
35 35,397 1,134
40 40,154 0,385
45 44,735 0,589
50 50,501 1,002

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FAST FOURIER TRANSFORM HARDWARE TESTING VIDEO

CONCLUSIONS AND NEXT PLANS

• Conclusions • Next Plans
1. Amplifier circuit can run well even though there is still an 1. Need to be improved on serial data transmission
error 0.271049% programs so that no data is lost when serially sending
2. The HPF circuit can run well even though there is still an data.
error 0.764583%. 2. Need to add a mini PC to replace a PC or laptop so that it
3. The Order 3 LPF series can run well even though there is easier to use.
is still an error of 0.8282%. 3. It needs to be developed to detect Alzheimer's using the

4. Acquisition of signal data from amplifier circuits and
filters can be acquired using Arduino UNO and can be
displayed on a PC GUI with 9600 baudrate, 10Hz
frequency, 125uV amplitude, and 50 data per second
data.
5. Retrieval of data during brain signal recording takes
place. The GUI receives as much as 2000 data serial
data and FFT is done to classify alpha brain signals in
the 8-13Hz range for normal people and alpha 4-7Hz
brain signal ranges for Alzheimer's people.
THANK YOU
Mild Cognitive Impairment (MCI) parameter and the
alpha3 or alpha 2 signal frequency power ratio with the
Relative Wavelet Entropy method.
4. Using special EEG electrodes from gold or silver and
electro cap for electrode installation so that the brain
signals are read better.

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HARDWARE TESTING DOCUMENTATION LITERATURE REVIEW

Conversion of mild cognitive impairment patients in Alzheimer’s disease: prognostic value of
Alpha3/Alpha2 electroencephalographic rhythms power ratio

Writter : D. V. Moretti
Publisher : Creative Commons Attribution 4.0 International License
Publication Year : 2015

About :
A higher alpha3 / alpha2 frequency power degradation ratio greater memory deficits
with greater cortical atrophy and decreased perfusional levels in the temporoparietal
cortex. And it was concluded that this patient was exposed to Alzheimer's. He
performed on 74 patients with mild cognitive impairment using EEG and compared
with MRI.

LITERATURE REVIEW LITERATURE REVIEW

Declining functional connectivity and changing hub locations in Alzheimer’s disease: an EEG EXTRACTION OF LEAD SIGNAL EPILEPSI USING FAST FOURIER TRANSFORM
study
Writter : Hindarto, Ade Efiyanti
Writter : Marjolein MA Engels, Cornelis J. Stam, Wiesje M. van der
Publisher : Simposium Nasional Teknologi Terapan (SNTT) 4
Flier, Philip Scheltens, Hanneke de Waal and Elisabeth CW van Straaten
Publication Year : 2016
Publisher : Creative Commons Attribution 4.0 International License
Publication Year : 2015 About :
The FFT method is used to convert / extract a signal into its basic frequency
About : component so as to obtain some features to capture the specific characteristics of the
Functional connectivity decreases with the severity of Alzheimer's patients on alpha EEG signal, time domain signal is converted to frequency domain. Backpropagation
signals. He performed on 318 Alzheimer's patients with severity (mild, moderate, method selected aims to build a system that is able to perform the classification of
severe) distribution and 133 normal people using EEG recording. epilepsy detected or not accurately based on input features obtained in the FFT
process.

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DIAGRAM BLOCK SYSTEM

FLOWCHART FAST FOURIER TRANSFORM

Source http://www.landasanteori.com/2015/10/pengertian-transformasi-fourier-diskrit.html

MECHANICAL DESIGN GUI DESIGN

Front View Top View

Isometry View Source: https://imamprofile.wordpress.com/research/

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GUI DESIGN