COLEGIUL TEHNIC „ION MINCU” DIN TG-JIU

SPECIALIZAREA ASISTENT MEDICAL DE FARMACIE

LUCRARE DE DIPLOMĂ

COORDONATOR
SÂRBU BOGDAN

ABSOLVENT
NEGREA RAMONA DANIELA

1
 COLEGIUL TEHNIC „ION MINCU„ DIN TG-JIU
SPECIALIZAREA ASISTENT MEDICAL DE FARMACIE

„PULBERI FARMACEUTICE”

COORDONATOR
SÂRBU BOGDAN

ABSOLVENT
NEGREA RAMONA DANIELA

2
 CUPRINS

INTRODUCERE............................................................................................................................4

CAPITOLUL I .CARACTERE GENERALE PRIVIN PULBERILEFARMACEUTICE...

1.1. N!ț"#$" %&$&'()& *'"+"$, *#)&'")& ('/(0&#"0&.................................................................

1.2. A+($(&)& ș" ,&3(+($(&)& *#)&'")!' ('/(0&#"0&...........................................................

CAPITOLUL II. CLASIFICAREA PULBERILOR FARMACEUTICE...................................5

2.1 C)(6""0('&( *#)&'")!' 0!$!'/ F('/(0!*&&" R!/7$& 8.....................................................5

2.2 C)(6""0('&( *#)&'")!' 0!$!'/ F('/(0!*&&" E#'!*&$& IV...................................................9

CAPITOLUL III. OB ȚINEREA ÎN INDUSTRIE ȘI FARMACIE A PULBERILOR

FARMACEUTICE...............................................................................................................................10

:.1 P'&*('('&( *#)&'")!' ;$ ('/(0"&.............................................................................................1<

:.2 P'&*('('&( *#)&'")!' ('/(0&#"0& ;$ "$,#6'"&.......................................................................21

CAPITOLUL IV. EXEMPLE DE PULBERI FARMACEUTICE.................................................2

4.1 S('& ='= 6!,"# .........................................................................................................................2
4.2 S='#'" *&$'# '&>",'(('& !'()=.................................................................................................2?
4.: S/&0(.......................................................................................................................................25
4.4 S#)( ,& ('"#...........................................................................................................................29
4. B($&!0"$ ...................................................................................................................................:<

CAPITOLUL V. CARACTERELE ȘI CONTROLUL PULBERILOR.

CALITĂȚI DE DEPOZITARE A PULBERILOR FARMACEUTICE ........................................:2

.1 C!$'!)#) 0()"=ț"" *#)&'")!' 0!$!'/ F('/(0!*&&" R!/7$& 8................................................:2

.2 C!$,"ț"" ,& ,&*!3"('& ( *#)&'")!' ('/(0&#"0&.......................................................................:4
CONCLUZII..........................................................................................................................................:
BIBLIOGRAFIE.....................................................................................................................................

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 CAPITOLUL I
1.CARACTERE GENERALE PRIVIND PULBERILE FARMACEUTICE.
.

1.1..N!ț"#$" %&$&'()& *'"+"$, *#)&'")& ('/(0&#"0&.

P#)&'")& 6#$ !'/& ('/(0&#"0& 6!)",&@ ()0(#"& ,"$ *('"0#)& #$"!'/& ()& #$&"( 6(# /("
/#)!' 6#6($ ț& (0"+&@ (6!0 "(& 6(# $# 0# 6#6( $ ț& (#")"('& 6#$ !)!6" & 0( (('& 6(# ,"+"3( & ;$
,!3& #$"('& ș" *! " (,/"$"6'(& *& 0()& !'()( 6(# (*)"0(& *& *"&)& 6(# /#0!(6& F.R.8.
$ 6#*)"/&$#) ,"$ 2<<4 () FR 8 6#$ ;$60'"6& #'/(!('&)& /!$!%'("" ,& *#)&'" 
 Pulberi pentru aplicare cutanata  *'&*('(& 0!$67$, ,"$ *('"0#)& 6!)",&@ )"&'&@

#60(& 0# %'(,& +( '"(& ,& "$& &. E)& 0!$ ț"$ #$( 6(# /(" /#)& 6# 6($ ț& (0"+& 0# 6(#
('( &0"*"&$ț" ș"@ ,(0= &6& $&0&6('@ /(&'"" 0!)!'($& (#!'"3(& 6& *'&3"$( 0( *#)&'"
#$",!3= 6(# /#)",!3=.
 Pulberi orale  *'&*('(& 0& 0!$6(# ;$ *('"0#)& 6!)",&@ )"&'&@ #60(& 0# +('"(& %'(,&
,& "$&ț&.țE)& 0!$ "$ #$( 6(# /(ț " /#)& 6#6($ș & (0ț"+& 0# 6(# ('= &0"*"&$ " "@ ,(0=
&6& $&0&6('@ /(&'"" 0!)!'($& ș" ('!/("3($" (#!'"3( ț". S#$ (,/"$ "6'(& *& %#'( 0#
(*( 6(# () )"0>", ș" 6& *'&3"$= 0( *#)&'" #$",!3= 6(# /#)",!3=.
 Pulberi utilizate pe alte cai  *#)&'" (#'"0#)('&@ *#)&'" !()/"0&@ *#)&'" *&$'#
*"0(#'" !'()& 6(# *'&*('(& )"0>",& ,& #3 !'()@ *#)&'" *&$'# 6"'!*#'"@ *#)&'" $(3()&@
*#)&'" *&$'# "$&0
ș ț"" " *&'#3""@ *#)&'"ț *&$'# "$>()(
ș ""@
ț *#)&'" *&$'# 6!)# "" "

6#6*&$6"" '&0()&@ 0('& '&#"& 6= ;$,&*)"$&(60= 0!$,"ț"")& ,& )( /!$!%'("")& '&6*&0"+&.

D&$#/"'&( ,& pulbere *'!+"$& ,"$ 6#6($"+#) )("$ pulvis, pulveris  *'(@ *#)&'&.
O 0(&%!'"& (*('& ! 0!$6"#"& pudrele  *#)&'" ,& #3 &&'$@ 0# %'(, (+($6( ,& ,"+"3"#$&@
,&6"$(& (*)"0('"" *& *"&)& 6(# *& /#0!(6&@ "$ 60!* &'(*&#"0 6(# 0!6/&"0.
D"$ *#$0#) ,& +&,&'& () 6"6&/#)#" ,"6*&'6@ *#)&'")& 6#$ 0!$6",&'(& sisteme disperse
eterogene ,& 6!)", "$ %(3  ?4 6!)",@ 2 (&'.
D"$ *#$0 ,& +&,&'& "3"0@ !'/( ('/(0&#"0( ,& *#)&'& 6& *'&3"$( "$ 6('&( ,& (%'&%('&
6!)",(@ ""$, ()0(#"( ,"$ *('"0#)& 6!)",&@ ,& !'/( 6" ,"/&$6"#$" ,"&'"&@ ,"6*&'6(& ,"+"3(& "$@ 0('&

"6" /&$"$ *'!*'"&(")& )!' "$,"+",#()&.

C( !'/( ('/(0&#"0(@ *#)&'") & 6#$ '&0+& $ "$()$"& (( "$ "$,#6'"& @ 0( 6" "$ *'(0"0( ,&
!"0"$( &)& 6#$@ "$ %&$&'()@ /#) /(" 6(")& ,"$ *#$0 ,& +&,&'& "3"0!-0>"/"0 6" /"0'!"!)!%"0@ ,&0(


!'/&)& ('/(0&#"0& )"0>",& 6" 6&/"6!)",&. D"$ (0&6& 0!$6",&'&$&@ !'/( ('/(0&#"0( ,& *#)&'& +(
" *'&&'(( *&$'# !'/#)('&( #$!' *'!,#6& 0# 6#6($& (0"+& 0('& *'&3"$( 6(")"(& '&,#6(.
D(0( #")"3('&( ,& *#)&'" 0( (('&@ (( ,& ()& !'/& ('/(0&#"0& )"0>",&@ 6&/"6!)",& 6" 6!)",&
&6& )"/"((@ !)!6"'&( *#)&'")!' "$ *'&*('('&( ()!' !'/& ('/(0&#"0& &6& /#) &"$6(.
A6&)@ /#)& 6#6($& /&,"0(/&$!(6&@ 0( *#)&'&@ "$'( "$ 0!/*!3""( ,"&'"&)!' !'/&

('/(0&#"0& 6#6*&$6""@ #$%#&$&@ *(6&@ 6#*!3"!('&@ 0(*6#)&@ 0!/*'"/(&@ %'($#)&@ 6#6*&$6""

"$&0(")&@ "/*)($#'"@ 6#6*&$6"" !()/"0&@ 6#6*&$6"" !"0&@ 6#6*&$6"" '"$!)!%"0&@ (&'!6!)".
I$ *)#6@ /(!'"(&( 6#6($&)!' 6!)",&  6#6($& /&,"0(/&$!(6& 6" 6#6($& (#")"('& 6#$
)"+'(& 6" 6& *(6'&(3( "$ +'(0 6# !'/( ,& *#)&'&.
D"$ (0&6& /!"+&@ &6& "/*!'($ 6( 6& 0#$!(60( *'"$0"*()&)& *'!*'"&(" ()& *#)&'")!'@
0('(0&'"6"0" 0('& "$)#&$&(3( 0()"(&( !'/&" ('/(0&#"0& "$ 0!/*!3""( 0('&"( &)& 6#$ "$0)#6&  0(
/(&'"& *'"/(@ 0( (3( "$&'/&,"('( 6(# 0( *'!,#6 "$".

1.2.A+($(&)& ș" ,&3(+($(&)& *#)&'")!'.

A. A+($&&)& *#)&'")!'@
 F(0")"(& ,& (/&6&0('& 6" !/!%&$"3('&

 F(0")"(& ,& (,/"$"6'('& 6# !'/( ,& *#)&'" 6& *! (6!0"( 6" (,/"$"6'( /#)& 6#6($&
/&,"0(/&$!(6&
 F(0")"(& ,& ,!3('&
 S(")"(& 6#*&'"!('( ( 6#6(&)!' (0"+& *'"$ *'&)#0'('&( )!' 6# !'/( ,& *#)&'&@
0!/*('("+ 0# ()& !'/( ('/(0&#"0&
 O /(" /('& (0"+"(& ('/(0&#"0( ,(!'"( 6#*'(&&" 6*&0""0& /('"
 A6!'"( 6#6($&)!' /&,"0(/&$!(6& ,"$ *#)&'" &6& /(" /('& ,&0( ,"$ ()& !'/&
('/(0&#"0&
 T'&0&'&( '(*",( "$ 6!)#"& ( *#)&'")!'@ ,#*( "$%&'('&@ /(" *'&3"$( 6" (+($(#) /"06!'('""
'"60#)#" ,& (*('""& ( #$!' "'"("" ()& '(0#)#" %(6'!"$&6"$()
 S#$ ! !'/( ('/(0&#"0( 0!$+&$(")( *&$'# !'/#)('")& "$ 0('& ,!3( ,& (,/"$"6'( &6&
/('&
 S#$ #$ /!, 0!$+&$(") *&$'# &)"&''('&( 6" (,/"$"6'('&( #$!' 6#6($& "$6!)#")&  6('#'"
,& "6/#@ !", 6" 0('!$( ,& 0()0"#@ !", 6" 0('!$( ,& /(%$&3"# &0
 S& *! !'/#)( 6" ('"0( 6# !'/( ,& *#)&'" ! 6&'"& ,& 6#6($& /&,"0(/&$!(6& 0('& 6#$
"$6(")& "$ /&,"# )"0>",.


B. D&3(+($(&)& *#)&'")!'@
 G#6#) $&*)(0# 6(# (/(' () #$!' 6#6($& (0"+&

 D""0#)(&( ,& ( *'!&( ,& ,&60!/*#$&'& *#)&'")& 0('& 0!$"$ 6#6($& >"%'!60!*"0&@
,&)"0+&60&$& 6(# /(&'"()& ('!/("0&@ +!)(")&
 F('"0('&( *#)&'")!' $&0&6"( #$ "/* "$,&)#$%(@ 0# +('"(& !*&'("" &>$!)!%"0&  #60('&@
/('#$"'&@ *#)+&'"3('&@ 0&'$&'&@ ,"+"3('&@ 0!$,""!$('&@ (/()('& 6" #$&!'" 6&'")"3('&
 F('"0('& 0!6"6"!('& "/*#6( ,& 0'&&('&( ,& "$+&)"6#'" "$,"+",#()& *&$'# ,!3&)& ,& *#)&'"
 N# 6& *! (,/"$"6'( 6# !'/( ,& *#)&'" 6#6($& 0('& 6#$ "$(0"+(& "$ 6!/(0
 P&$'# ( (+&( &"0(0"(& &'(*&#"0(@ *#)&'")& '&#"& 6( "& #$ (/&6&0 !/!%&$ ,"$ !(&
0!/*!$&$&)& 6" '&#"& 6( *'&3"$& ! /('"/& (+($(!(6( ( *('"0#)&)!'
 P'"$ /('"'&( 6#*'(&&" ,& 0!$(0 0# (%&$"" &&'$"@ 6(")"(&( 6#6($&)!' *#)+&'"3(& &6&
,"/"$#(( 0!/*('("+ 0# ( 0&)!' $&*#)+&'"3(&
 P&'"0!)#) +('"("")!' /('" "$ ,!3('&( 6#6($&)!' !('& (0"+& "$ 0(3#) *#)&'")!' $&,"+"3(&
(,/"$"6'(& *& 0()& !'()(  /(6#'" (*'!"/("+&
 I$&)&%&'&( %'&6"( ,& 0('& *(0"&$ ( /!,#)#" ,& #")"3('& 0!'&0( ( *#)&'""
 P#)&'")& +'(0 6#$ /(" ,""0") ,& '($6*!'(
 U$"" *(0"&$ ț" 6#*!'= /(" %'&# "$%>" "'&( ,& *#)&'"@ ,"$ 0(#3( %#6#)#" $&*)(0#  6(# (0"#$ ""
"'"($& (6#*'( /#0!(6&".

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 CAPITOLUL II
CLASIFICAREA PULBERILOR
2.1. C)(6""0('&( *#)&'")!' 0!$!'/ F('/(0!*&&" R!/7$& 8.

P#)&'")& 6& *! 0)(6""0( ,#*( /(" /#)& 0'"&'"" (6&) 

 Natura si srcinea materiilor prime:
 P#)&'" ,"$ *'!,#6& $(#'()&

• V&%&()&
• A$"/()&
• M"$&'()&
 P#)&'" ,"$ *'!,#6& ,& 6&/"6"$&3(
 P#)&'" ,"$ *'!,#6& ,& 6"$&3(.
 Modul de formulare:
 P#)&'" /(%"6'()&
 P#)&'" !"0"$()&
 P#)&'" "$,#6'"()&
 Compozitie:
 P#)&'" 6"/*)&  ! 6"$%#'( 6#6($( (0"+(
 P#)&'" 0!/*#6&  0&) *#"$ ,!#( 6#6($& (0"+&
 Conditiile de fabricare
 P#)&'" $&6&'")&
 P#)&'" 6&'")&  !()/"0&@ ('6#'"@ ($""!"0&@ *"&)&( 6#%('#)#"@ '($"
,&60>"6&

 Modul de dozare
 P#)&'" $&,"+"3(&  /#)",!3&
 P#)&'" ,"+"3(& "$ ,!3( #$"('&@ 0!$,""!$(& "$,"+",#()  #$",!3(
 Gradul de finete: 0!$!'/ FR 8
 P#)&'" %'!60"!('&  IV 
 P#)&'" /")!0""  V 
 P#)&'" 6&/""$&  VI 
 P#)&'" "$&  VII 

5
  P#)&'" !('& "$&  VIII 
 P#)&'" &'("$&  I8 
 P#)&'" 0!)!",()&.

2.2.C)(6""0('&( *#)&'")!' 0!$!'/ F('/(0!*&&" E#'!*&$& IV.

F('/(0!*&&( E#'!*&&($( IV 0)(6""0( *#)&'")& ,#*( %'(,#) ,& "$&& (6&)

1. *#)&'& %' !6"&'(
2. *#)&'& /!,&'( ,& "$(
:. *#)&'& "$(
4. *#)&'& !('& "$(
 Calea de administrare

 P#)&'" 0('& 6& (,/"$"6'&(3( *& 0()& !'()(  ,& #3 "$&'$

 P#)&'" 0('& 6& (,/"$"6'&(3( *& *"&)&  ,& #3 &&'$

 P#)&'" 0('& 6& (,/"$"6'&(3( *& /#0!(6&@ ,& #3 &&'$  !()/"0(@ !"0(@
$(3()(@ #0()(@ +(%"$()( 6" '&0()(
 P#)&'" 0('& 6& (,/"$"6'&(3( *& 0(")& *('&$&'()&  *#)&'" 6&'")&@ 0('& 6&
,"3!)+( 6(# 6& 6#6*&$,( „& &/*!'&”
 Modul de administrare
 P#)&'" 0('& 6& (,/"$"6'&(3( 0( (('&@ "$ !'/( 6!)",(
 P#)&'" 0('& 6#$ ,&6"$(& *'&*('('"" ,& )"0>",&  6!)#""@ 6!)#""

&&'+&60&$&@ 6"'!*#'"@ 6#6*&$6""@ &/#)6""

 P#)&'" ,&6"$(& *'&*('('"" ,& /&,"0(/&$& "$&0(")&  6!)#"" 6" 6#6*&$6""
 P#)&'" *&$'# *'&*('('&( ,& 0!)"'&  6!)#"" 6" 6#6*&$6""
 P#)&'" "!(,&3"+&
 Actiunea farmacologica
 P#)&'" /&,"0(/&$!(6&
 P#)&'" 0!6/&"0&.

9
 CAPITOLUL III

OBȚINEREA N INDUSTRIE ȘI FARMACIE A PULBERILOR

'.1.PREPARAREA PULBERILOR IN FARMACIE.

P'&*('('&( *#)&'")!' )( '&0&*#'= &6& (6=3" /(" '&0+&$ ;$7)$"= ;$ ('/(0"")& ,& 0"'0#"
;$0>"6@ ,&07 ;$ ('/(0"")& *#)"0&@ ,(' ș" (0!)! ;$ $#/=' /"0. A0&(6( 6& ,(!'&(3= ('"0='""@ 0( ș" ;$
0(3#) ()!' !'/& ('/(0&#"0&@ ( #$#" $#/=' /('& ,& *'!,#6& "$,#6'"()&.
În farmacie 6& *'&*('=
 pulberi magistrale

 pulberi oficinale
 pulberi 0('& 6& '($6!'/= ex tempore ;$ 6!)# ț"&@ 6"'!*@ 6#6*&$6"&@ 6!)#ț"& &&'+&60&$=
 pulberi compuse ,"$ !'/& ('/(0&#"0& "$,#6'"()& 6!)",&.
P#)&'")& /(%"6'()& 6& *'&*('= )( /(6( ,& '&0&*#'=@ "(' *#)&'")& !"0"$()&@ ;$ )(!'(!'#)
('/(0"&". S& #")"3&(3= (*('(#'( ,"$ ,!('&( ('/(0"&" "$6'#/&$& ,& 07$='"'&@ /!('& 0# *"6")&@
(*('(& &)&0'"0& ,& *#)+&'" 3(@ /!('& /&0($"0&@ &0.. T!(& #6&$6")&)& ș" (*('(#'( +!' " /&$ ț"$#&
;$'-! 6('& ,& 0#'=ț&$"& *&'&0= ș" ,& #$0 ț"!$('& 0!'&0=.
$ ('/ (0"&@ pulberile nedivizate 6& '&*('"3&(3= ;$ 0#"" ,& (/"$!*)(6@ !'0($& ,& 6"0)=@
*#$%" ,& >7'"& 6"/*)= 6(# 0&'(=. O (&$ț"& ,&!6&"= 6& +( (0!',( *#)&'")!' ,& #3 &&'$ ș" ($#/&
pudrelor sterile@ 0('& 6& +!' 0!$,"ț"!$( ;$ '&0"*"&$& 6&'")"3(&.
Pulberile divizate 6& '&*('"3&(3= ;$ 0(*6#)& ,& >7'"&@ *#$%" ,& >7'"&@ 0(*6#)& (/")(0&&@
0(*6#)& %&)("$!(6& ('".
Capsulele de hrtie 6#$ 0!$&0 ț"!$(& ,"$ >7'"& 6"/*)= 6(# 0&'(= *&'%(/"$(= ș" (# !'/=
,'&*#$%>"#)('=. S#$ $#/&'!(& ,#*= 0($"(&( ,& *#)&'& *& 0('& ! *! 0!$," ț"!$(@ ;$ /='"/"
6($,(',@ ,& )( <@1% )( 1<%.
Capsulele amilacee 0(ș&&@ >!6"(@ #)"$& 6#$ ;$+&)" ș#'" *&$'# *#)&'" *'&*('(& ,"$'-! 0!0=
,& (/",!$ ș" %)"0&'"$= 6(# #)&" ,& '"0"$ 1%@ 0( *)(6"0"3($ ș" 6#6($ț& 0# '!) 0!$6&'+($ $"*(&6&'".
S#$ !'/(& ,"$ ,!#= #/== ț" ,& !'/= 0")"$ ,'"0=@ 0('& 6& *! ;/ "$( *'"$ (* =6('& # ș!('=.
A0&6& ;$+&)"#'" !&'= (+($(#) #$&" (,/"$"6'='" #!('& *'"$ #/&0('& 0# (*=@ (0&6&( 6&
;$/!("& ;$ 60#' "/* " 6& ,"%&'= 6# (0K"#$&( /&0($"0= ( !)#)#" ()"/&$(' () &'/&$K")!' %(6'"0"@

1<
&)"&'7$, 6#6($K&)& "$0)#6& ;$ &)&.
C(ș&&)& (/")(0&& *'&3"$= ,&3(+($(#) 0= 6#$ *&' /&(")& )( (&' " +(*!'" ,& (*=@ 0&&( 0& )&
(0& "/*'!*'"" *&$'# 0!$,"K"!$('&( 6#6($K&)!' >"%'!60!*"0&@ &)!'&60&$&@ (/&6&0#'" &#&0"0&@
&'(0& +&%&()&@ 0='#$&. S& '&0!/($,= (/()('&( 0( ș&&)!' 0# *#)&'& ;$ 0#"" ,& (/"$!*)(6@
!'0($& ,& 6"0)= 6(# *#$%" ,& >7'"& 0&'(=.

Capsulele gelatinoase 6#$ ;$+&)"#'" ,"$ %&)("$= #")"3(& /(" /#) ;$ "$,#6'"( ,&
/&,"0(/&$&@ 0('& 0!$,"K"!$&(3= 6#6($K&)& /&,"0(/&$!(6& 6!)",& 6(# )"0>",&.
S#6($K&)& +!)(")& " >"%'!60!*"0& *! " *'!&(& "$& *'"$ #")"3('&( ,& >7'"" 0&'(&@ *)"(&
,#)#. C(*6#)&) & (/")(0&& 0( ș&&)& " 0(*6#)&)& %&)("$!(6& ('" 0(*6#)& !*&'0#) (& $# 6& ('#$0=
(0&6&( 6& ;$%>" !,(= 0# 0!$K"$##).

Fazele preparării pulberilor în farmacie

$ ('/(0"&@ !'/&)& /(%"6'()& ,& *#)&'& 6& *'&*('= )( 0&'&'&@ *& (3= ,& '&K&= !'/&)&
!"0"$()& 6& *'&*('= ;$ 0($"=K" /"0". P'&*('('&( &6& &&0#(= ,& 0='& ('/(0"6@ 0# #$ /"$"/#/ ,&
&0>"*(/&$ ,& )#0'#.
Pulberile simple 6& !K"$ ,"$ 6#6($K& /&,"0(/&$!(6& 6!)",&@ #60(& ;$ *'&()(") ,(0= &6&
0(3#)@ *#)+&'"3(& ;$ /!('& 6(# /!'" ,& ,"&'"& "*#'" " '&0#& *'"$ 6"&)& "$,"0(& ;$ /!$!%'("")&
'&6*&0"+&.
Pulberile compuse se !K"$ *'"$ (/&6&0('&( 0!/*!$&$&)!' *'&60'"6&@ (,#6& )( #$ %'(, ,&
/='#$K"'& (*'!*"( " (,=#%(& ;$ !',"$&( 0'&60=!('& ( 0($"=K")!'@ 0# &0&*K"( 0&)!' 0# ,&$6"(& /('&
0('& 6& (,(#%= )( ;$0&*#. D#*= (/&6&0('&@ *#)&'")& 6& '&0 *'"$ 6"( "$,"0(= " 6& !/!%&$"3&(3= ,"$
$!#.
Cernerea &6& !)"%(!'"& *&$'# *#)&'")& 0('& 6#$ *'&60'"6& in c!ntit!"i mai mari de #$ g %
$ 0(3#) #$#" *'&*('( /(%"6'()@ (3&)& *'&*('='"" #$&" *#)&'" 6#$ #'/=!('&)&
 +&'""0('&( '&K&&"
 +&'""0('&( ,!3&)!' &'(*&#"0& /("/& #$,& &6& 0(3#)
 ()&%&'&( /&!,&" ,& *'&*('('&@ ( #6&$6")&)!'@ ( "*#)#" ,& 0!$,"K"!$('&
 07$='"'&( 0!/*!$&$&)!'
 *#)+&'"3('&
 0&'$&'&
 (/&6&0('& " !/!%&$"3('& 
 6&'")"3('& &+&$#()= *#)&'" 6&'")& *&$'# *)=%"@ ('6#'"@ *"&)&( 6#%('")!' 0# ($""!"0&
 ,"+"3('&
 0!$,"K"!$('& " (/()('&.

11
  Verificarea reţetei - ('/(0"6#) ('& !)"%(K"( 6= +&'""0& ,(0= '&K&( ( !6 ;$!0/"=@ !'/#)(=
0!'&0 " ('& 0!/*)&(& !(& ,(&)& $&0&6('&.
 Verificarea dozelor terapeutice maxime - ,(0= ;$ !'/#)= 6#$ *'&60'"6& 6#6($K&
/&,"0(/&$!(6& ,"$ %'#*&)&  „S&'*($,#/ " „V&$&'#/@ *&$'# (0&6&(@ 6& +&'""0= ,!3&)&
&'(*&#"0& /("/&. $ 0(3#) ;$ 0('& (0&6& ,!3& 6#$ ,&*="&@ 6& *'!0&,&(3= 0!$!'/ '&%#)")!'
0#$!60#&@ 0('& 6& (*)"0= " *&$'# ()& !'/& ,"+"3(&.
 Alegerea metode i de pr eparare, a ustensilelor, a tipului de condiţionar e - 6& +( K"$& 6&(/( ,&
*'!*'"&=K")& "3"0!-0>"/"0& ()& 6#6($K&)!' 6!)",& (6!0"(& "@ &+&$#()@ ,& /!,#) ,&
"$'!,#0&'& ( #$!' 6#6($K& 6&/"6!)",& 6(# 0>"(' )"0>",&.
$ ('/(0"&@ *'&*('('&( *#)&'")!' 6& &&0#&(3= ;$ /!('@ 0# ! 0(*(0"(& ,& -1< !'" /(" /('&
,&07 +!)#/#) "$() () *#)&'"".
S#6($K&)& >"%'!60!*"0& 6& #6#0= " ,#*= *#)+&'"3('&@ *&$'# ( ;$,&*='( #/","(&( "(=@ ;$
"/*#) (0&6&" !*&'(K"".

C7$, 6& *'&60'"# 6#6($K& &)!'&60&$& 0'"6()"3(& 6#)( ,& 6!,"#@ !6( ,"6!,"0@ 6#)( ,&
/(%$&3"# ;$ (/&6&0 0# ()& *#)&'"@ 6& +!' #")"3( 6#6($K&)& #60(& 6(# ($>",'& ;$ 0($"=K"
0!'&6*#$3=!('&. D"&'&$K( ;$ /(6= 6& 0!/*)&&(3= 0# )(0!3= *&$'# ( /&$K"$& ,!3(#) "$,"0(.
S#6($K&)& !('& (0"+& 6& *'&*('= 6# !'/= ,& pulberi titrate, !K"$#& *'"$ ,")#('& 0#
)(0!3= #60(=@ ;$ *'!*!'K"& ,& 1(1< 6(# 1(1<<. U/","(&( (0&6!'( $# '&#"& 6= ,&*=&(60= 1.
P#)&'")& &&'+&60&$& 6& *'&*('= ,"$ 6#6($K& ,&6>",'((& " $# '&#"& 6= ("= ! #/","(&
/(" /('& ,& 1   )( ,"3!)+('& ;$ (*=@ 6& !K"$& ! 6!)#K"& )"/*&,& 6(# !*()&60&$= " 6& *'!,#0&
&&'+&60&$K=.
S#6($K&)& ,&)"0+& 60&$& 0)!'#'( ,& 0()0"# 0#  /!)&0#)& ,& (*= $# *! " *'&)#0'(& 6#
!'/= ,& *#)&'".
 Cntărirea componentelor
L( *'&*('('&( *#)&'")!'@ 6& !)!6&60 /")!(0& ,& 07$='"'& 6(# ,& ,"+"3('& ,& ! *'&0"3"& 0('& 6=
*&'/"= '&6*&0('&( 0!$,"K"")!' /!$!%'("&" &P'()*+*- ,"$ FR 8.
P&$'# 07$='"'&( #$!' 0($"=K" /(" /"0"@ 6& #")"3&(3= (6=3" ()($K& &)&0'!$"0& ,& "* M&)&'@
S('!'"#6  *&$'# 0($"=K" /(" /('"@ 6& "$,"0= ()($K( &>$"0= ,& '&0&*#'= ,& "* S""#.
 Pul!erizarea componentelor - *&$'# *'&*('('&( 0($"=K")!' /"0" ,& *#)&'"@ *#)+&'"3('&(

6#6($K&)!' 6!)",& 6& '&()"3&(3= *'"$ !*&'(K"( ,& triturare.frecare ;$ /!('&@ *"#)"K&@ *& *!'"'@
"(' *'!,#6#) &6& *#)+&'"3( ;$'& *"6") " *&'&&)& /!('#)#".
P"6")#) 6& ;$+7'&& 0"'0#)('@ "(' !'K( ,& *'&6('&@ '"#'('& 6(# )!+"'& &6& ,&*&$,&$= ,&
,#'"(&( /(&'"()#)#".
P'!0&6#) ,& '&,#0&'& ( 6#6($K&)!' 6!)",& ;$ *('"0#)& "$&@ *'"$ '&0('&( )!' ;$ /!('@ 0#

12
(#!'#) *"6")#)#"@ &6& ,&$#/" triturare '. triturer  ( '"#'(@ ( 6='7/(@ ( 3,'!"@ ( *#)+&'"3( " )( %
tritus, .a, .um " '&0( 6(# ,& )( tero, .trivi, .tritum, .terere  ( '&0(@ ( *"6(. D& (6&/&$&( &'/&$#)
,&6&/$&(3= *'!0&6&)& *'"$ 0('& #$ (/&6&0 ,& *#)&'" "$& 6#$ (/&6&0(& "$"/ ;$'-#$ /!('.
T'"#'('&( 6& &&0 #&(3= ,& )( dreapta la stnga, 0"'0#)('@ 0# (*=6('& *#&'$"0= *& *&'&K""
/!('#)#"@ ,&*&$,&$ ,& $(#'( 6#6($K&" 6!)",&. $ (0&6 *'!0&,&#@ *"6")#) (0K"!$&(3= *'"$ '&0('& "

*'&6('&@ /(&'"()#) ""$, 3,'!" ;$'& (3( *"6")#)#" 0('& 6& /"0= 0"'0#)('@ #$,#) " *&'&K"" /!('#)#".
$ *'(0"0( ('/(0&#"0=@ '!"'&( *"6")#)#" ('& )!0 ;$ 6&$6 "$+&'6@ (K= ,& /"0('&( (0&)!' 0&(6!'$"0#)#"@
"(' *!3"K"( *"6")#)#" &6& #!' ;$0)"$(=. $ "/*#) '"#'='""@ 6& !)!6&60 6*(#)& )&"")& 6(# 0('&)& ,&
0&)#)!", *&$'# ( (,#$( /(&'"()#) 0('& (,&'= ,& *&'&&)& /!('#)#" " ,& *"6").
T'"#'('&( 6& (*)"0= /(!'"=K"" 6#6($K&)!'. E6& /(" "$,"0(= *&$'# 6#6($K&)& /(" *#K"$ ,#'&
" *&$'# 0&)& 0('& 6& ;$0=)3&60@ 6& ;$/!("& 6(# 6& ,&60!/*#$ *'"$ )!+"'&.
M"0('&( " (/&6&0('&( 0"'0#)('= ( *"6")#)#" *& *#)&'&( ,"$ /!(' 0!$,#0& )( (/&6&0('&(
0!/*!$&$&)!' " )( 6='7/('&( (%'&%(&)!' 6)(& ,& *#)&'&. P'"$ (*)"0('&( #$&" *'&6"#$" (6#*'(
*"6")#)#"@ 6& *!(& &&0#( " ! 3,'!"'& 6(# ! /='#$K"'& ( 6!)",#)#".
M!run"irea #0=K")!' /('" ,& /(&'"() 6& *!(& &&0#( *'"$ )!+"'&(  *"6('&( &&0#(= ,& 0='&
*"6") *&'*&$,"0#)(' (6#*'( 6!)",#)#" ()( ;$ /!('.
C($"(&( ,& 6#6($K= /='#$K"= '&#"& 6= "& 0!'&6*#$3=!('& ,"/&$6"#$")!' /!('#)#"@
*&$'# 0( )!+"#'")& 6= "& &"0(0&. C7$, 6& )#0'&(3= 0# $"& 0($"=K" *'&( /"0"@ *"6")#) *!(& 6*('%&
/!('#) )!+"$, ;$ %!)@ "(' ,(0= 6#$ 0($"=K" *'&( /('" ,& /(&'"()@ )!+"#'")& 6#$ (/!'"3(& ,& /(6(
,& 6#6($K=.
L!+"'&( 6& #")"3&(3=@ ;$ 6*&0"()@ *&$'# 6#6($K&)& ,#'& (0", (''"0@ ()(#$ 6(# *'!,#6&)&
+&%&()& 0# K&6##'" /(" ('" '=,=0"$= ,& "*&0(.
R&%#)" *'(0"0& ,& *#)+&'"3('& 
 !*&'(K"( ,& *#)+&'"3('& 6& &&0#= )( )!0 #60(
 "&0('& "$%'&,"&$ 6& *#)+&'"3&(3= 6&*('(
 $# 6& *#)+&'"3&(3= 0($"=K" /('" ,& 6#6($K= ,&!,(= 
 6#6($K&)& ($>",'& 6& *#)+&'"3&(3=@ ,& (6&/&$&(@ 6&*('(
 6#6($K&)& 0('& 6& ,&60!/*#$ $# 6& '"#'&(3= &$&'%"0 6='#'")& ,& /&'0#'@ 0)!'(#) ,& *!(6"#@
(3!(#) ,& ('%"$@ 6='#'")& 0!)!",()&@ ,& ('%"$ &0.
 6#6($K&)& 0!)!'(&@ 0!)!'($&@ 6!)",& +!)(")&@ !",($&@ '&,#0=!('& 6(# 0# /"'!6 *&'6"6&$ 6&
+!' *#)+&'"3( ;$ /!('& 6*&0"()&@ ,&6"$(& $#/(" (0&6!'(
 6#6($K&)& 6&/"6!)",& /!" 6& *#)+&'"3&(3= *'"$ "$&'/&,"#) 6#6($K&)!' 6!)",& "$&'&
 *#)&'")& *#&'$"0 (0"+&@ !"0& 6(# "'"($& '=,=0"$( ,& "*&0(@ '#$3&)& ,& &)(,!$=@ ,"%"()(@
0)!'#'( /&'0#'"0= 6& *#)+&'"3&(3= ;$ /!(' 6# $"= 6(# /!'" ,& 0(*(0"(& /"0=@ (0!*&'"&@

1:
 *&$'# ( &+"( ;/*'="&'&( 6#6($K&" 6!)",& "$ *#)+&'"3(&@ ;$ (/!6&'= " "$!"0('&( !*&'(-
!'#)#" 
 *#)&'" 0# %'(, /('& ,& "$&K& 6& !K"$ *'"$ *!'"'"3('&. S#6($K( #60(= 6(# (/&6&0(=@ 0# #$
6!)+&$ (,&0+(@ 6& '"#'&(3= *& ! *)(0= ,& 6"0)=@ *!'K&)($@ (%( 6(# *!'"'@ 0# #$ *"6") ,"$
(0&)(" /(&'"()@ ,(' 0# (3( *)(=. M&!,( 6& #")"3&(3= '&0+&$ ;$ *'(0"0( 6!/(!)!%"0=
 6#6($K&)& (,&'&$& ,& *"6") 6(# ,& *&'&K"" /!('#)#" 6& ;$,&*='&(3= 0# ! 0('&)= ,"$ /(&'"()
*)(6"0 
$ %&$&'()@ !*&'(K"( ,& *#)+&'"3('& 6& &&0#&(3= *7$= 0& ! /(&'"()#) &6& '($6!'/( ;$
*#)&'&  ;$ (0&6 0(3@ 6& '&()"3&(3= ! pulverizare integral! 6(# f!r! reziduu% U$ &+&$#() '&3",## )(
0&'$&'& 6& *#)+&'"3&(3= ,"$ $!# " 6& ;$0!'*!'&(3= ;$ (/&6&0  6#$ ;$6= 0(3#'" 07$, &6& (+($(!(6=
pulverizarea cu reziduu - (#$0" 07$, *='K")& /(" ,#'&@ %'&# ,& *#)+&'"3(@ ()& *'!,#6#)#" +&%&() $#
0!$K"$ *'"$0"*"" (0"+&. E6& 0(3#) '=,=0"$"" ,& "*&0( 0# 6'#0#'= $&!/!%& $=@ ;$ 0('& ()0()!"3 "" 6#$
)!0()"3(K" ;$ K&6##) 0!'"0() " )"&'"($ '"(")@ "(' *'"$ *#)+&'"3('&( !"$#"=@ K&6##) )&/$!6 '=/7$& ;$
'(%/&$& /(" /('" 0('& 6#$ ;$,&*='(& *'"$ 0&'$&'& 6& 0!$6",&'= 0= '&3",##) )( 0&'$&'& &6& ,& 2 /
'&*'&3&$7$, *'!*!'K"( ,& K&6# )&/$!6 ,"$ '=,=0"$( ,& "*&0( 6#*#6= *#)+&'"3='"". D(0= ;$ #'/(
*#)+&'"3='""@ 6& !K"$& ! *#)&'& /(" 0!$0&$'(= ,&07 0&( *'&+=3#= ,& FR 8@ 6& "$,"0= ,")#('&( 0#
)(0!3= *#)&'&( ,& '=,=0"$= ,& "*&0(@ ,& !*"#@ ,& '#$3& ,& ,"%"()=.
U$&)& 6#6($K& 6!)",& 6#$ &)(6"0&@ "(' ()&)& "$, 6= 6& (%)!/&'&3& !'" 6= '&3"6& /=0"$='"" *'"$
6"/*)( '"#'('& 0# *"6")#) ;$ /!(' *&$'# (0&6& 6#6($ K&@ 6& (*)"0= /&!,( ,& pulverizare prin
intermediu% A0&6( &6& *'!0&6#) ,& '&,#0&'& ( /='"/"" 6!)",&)!'@ 0# (#!'#) #$#" /(&'"() (,"K"!$()@
0('& *!(& " #!' &)"/"$( ,#*= 0& *#)+&'"3('&( ( !6 0!/*)&= 6(#@ ,"$ 0!$'(@ *!(& 6= '=/7$= ;$
*'!,#6#) "$(). S#6($K&)& 0('& 6& ;$,&*='&(3= !() ,#*= *#)+&'"3('&@ ,&$#/"& intermedii volatile
efemere0 6#$ )"0>",& +!)(")& !)!6"& *&$'#@ !K"$&'&( #$!' 6!)#K"" 0!$0&$'(& ,& 6#6($K& %'&# ,&
*#)+&'"3(@ ;$,&*='(& (*!" *'"$ 0!$"$#('&( '"#'='"" +!)(")"37$,#-6& ,& &&/*)#@ ()0!!) 6(# &&'
&")"0@ ;$ *'!*!'K"& ,& 1<@ *&$'# *#)+&'"3('&( 6#6($K&)!' /&$!)@ "!,@ 0(/!'@ "/!)@ (0", !'"0@ "
0)!'!!'/ *&$'# "!,@ (0", 6&('"0@ 6=*#$ ,& 6!,"#. S#6($K&)& #")"3(& 0( "$&'/&,"# *&$'#
*#)+&'"3('& " 0('& *! 6= '=/7$= ;$ (/&6&0 6& $#/&60 intermedii permanente fixe@ ,& &&/*)#
3(>='#) !)!6" *&$'# *#)+&'"3('&( #$!' *'!,#6& +&%&() & 0( 60)&'!K"" 0!'$#)#" ,& 6&0('= " +($")"(@
0)!'#'( ,& *!(6"#@ 6&/"$K&)& ,& /"%,()& (/('&@ 6&/"$K&)& ,& ,!+)&(0 6(# #)&"#) +&%&() *&$'#
*#)+&'"3('&( 0&(0&#)#".

U$&)& 6#6($K& 0# ,&$6"(& /"0= $# *! " *#)+&'"3(& ;$ /!(' ,&!('&0& 6& (%)!/&'&(3=. $
(0&6& 0(3#'"@ 6& *'!0&,&(3= )( pulverizarea prin frecare pe sit! 6(# radere pe sit!, (*=67$, #!'
#)%='"" ,& 6#6($K= (%)!/&'(= ,&(6#*'( #$&" 6"&@ ,& &&/*)# - *#)+&'"3('&( !",#)#" ,& /(%$&3"#
6(# 0('!$(#)#" ,& /(%$&3"# 0# 6"( IV.

14
  Cernerea solidelor - ,#*= *#)+&'"3('&( 0!/*!$&$&)!'@ &6& $&0&6('= !*&'(K"( ,& 0&'$&'&@ *'"$
0('& 6& 6&*('= *('"0#)&)& ,& ,"&'"& /='"/". D"$'-#$ (/&6&0 *!)","6*&'6@ 6& 6&*('= ! 6"$%#'=
0(&%!'"& ,& *('"0#)& 0# ! ($#/"= ,"/&$6"#$& 6(# 6& 6!'&(3= '(0K"#$" 0# ,"/&$6"#$" ,"&'"&.
FR 8 *'&+&,& 0&'$&'&( !)"%(!'"& *&$'# 0($"=K" ,& *#)&'" 6(# (/&6&0#'" ,& *#)&'" 0('&
,&*=&60 2< %.
+eguli practice de cernere a pulberilor:
 O*&'(K"( ,& 0&'$&'& 6& '&()"3&(3= *'"$ /"0='" !60")(!'""@ ='= ( !'K( '&0&'&( *#)&'"" *'"$
(*=6('& 0# *"6")#)
 0&'$&'&( 6& &&0#&(3= '(*", 
 *&$'# 0&'$&'&( *#)&'")!' ,& 6#6($K& "'"($& 6(# !"0&@ 6& #")"3&(3= 6"& (0!*&'"& '=,=0"$(
,& "*&0(@ '#$& ,& ,"%"()=
 6#6($K&)& >"%'!60!*"0& " &)!'&60&$& 6& #6#0= ;$("$&( 0&'$&'""@ *&$'# ( &+"( 0!$%)!/&'('&(
*#)&'""

 0&'$&'&( 6& &&0#&(3= #")"37$, 0($"=K" 0!$+&$(")& ,& *#)&'&@ ;$ '(*!' 0# 6#*'((K( 6"&"@
)#0'7$,#-6& 0# *!'K"#$" /"0"
 *&$'# *#)&'")& )( 0('& /='"/&( *('"0#)&)!' &6& 6# 5< #/ 6(# )( 0('& 6& *'&+&,& ! ($#/"=
!'/= 0'"6()"$=@ ,&&'/"$('&( %'(,#)#" ,& /='#$K"'& 6& &&0#&(3= *'"$ /")!(0& (,&0+(&@
;$60'"6& ;$ $!'/&)& ,& 0()"(& ( *'!,#6#)#"
 &"0(0"(&( 0&'$&'"" &6& ,&*&$,&$= ,& %'(,#) ,& *#)+&'"3('& ( 6#6($K&"@ ,& )#$%"/&(
*('0#'6#)#" *#)&'"" *& '&K&(#( 6"&"@ ,& /"0('&( *'!,#6#)#" *& 6"= " ,& %'!6"/&( 6'(#)#"
*#)&'"" 0('& 6& 0&'$&
 '($,(/&$#) 0&'$&'"" 0'&&@ 0# 07 *('0#'6#) *'!0&6#)#" *& '&K&( &6& /(" )#$% " 6'(#) /("
6#K"'&
 *&$'# *#,'& " *#)&'" ,& #3 "$&'$ (6!'($&@ *($6(/&$& %(6'"0&@ 6& '&0!/($,= ! "$&K&
!('& (+($6(= - 6"&)& VII@ VIII@ I8 FR8
 *&$'# *#)&'")& 0('& 6& ,"3!)+= ;$("$& ,& ;$'&#"$K('&@ 6& "$,"0= #$ %'(, ,& ,"6*&'6"& /&,"# -
6"&)& V " VI FR 8.
 Amestecarea #i omogenizarea pulberilor - &6& ! !*&'(K"& ,& ;$'&*='#$,&'& ( *('"0#)&)!'
0!/*!$&$&)!' ;$'& &)&. A/&6&0#) !K"$# '&#"& 6= "& 6("6"0 !/!%&$.
$ *'(0"0( ('/(0&#"0=@ (/&6&0('&( *#)&'")!' 6& &&0#&(3= ;$ /!('@ 0# (#!'#) *"6")#)#" *'"$
'"#'('&@ 0# 0('&)& ,& 0&)#)!", 6(# 0# 6*(#)(. S& *! !)!6" " (*('(& (0K"!$(& &)&0'"0 /!'" 0# ")&
6(# /"&'& '!("+& ,& ,"/&$6"#$" /"0".
+eguli practice de amestecare a pulberilor
 '&()"3('&( #$&" *#)&'" !/!%&$& ,&*"$,& ,& /='"/&(@ !'/( " %'&#(&( 6*&0""0= (

1
 *('"0#)&)!'@ ,& /!,#) " "/*#) ,& (/&6&0('&
 *&$'# 0($"=K" /"0" ,& 6#6($K& 6!)",&@ 0('& (# ! %'($#)!/&'"& (*'!*"(=@ (/&6&0('&( 6&
'&()"3&(3= !,(= 0# *#)+&'"3('&( *'"$ '"#'('& ;$ /!(' &6& /(" "$,"0( 0( "&0('& 0!/*!$&$=
( *#)&'"" 0!/*#6& 6= "&@ ;$ *'&()(")@ *#)+&'"3(= "@ &+&$#()@ 0&'$#=
 #$ () (0!' 0('& "$)#&$K&(3= (/&6&0('&( &6& *'!*!'K"( 0!/*!$&$&)!'. FR 8 "$,"0= !',"$&(
,& (/&6&0('& ( 0!/*!$&$&)!' #$&" *#)&'". A0&(6( &6& ;$ #$0K"& ,& *'!*'"&=K")& "3"0& ()&
0!/*!$&$&)!' ;$ %&$&'()@ 6& &&0#&(3= ;$ !',"$&( 0'&607$,= ( 0($"=K")!' " ;$ '(*!' 0#
+!)#/#) 6#6($K&)!' 6!)",&  )( ;$0&*#@ 6& (,(#%= *#)&'")& 0# +!)#/ /"0.
A6&)@ ;$ 0(3#) *#)&'")!' 0!/*#6& 0('& 0!$K"$ 0!/*!$&$& ;$ *'!*!'K"" ,"&'"&@ 6& +!' (,=#%(@
)( ;$0&*#@ 0&)& ;$ 0($"=K" /(" /"0"@ (*!"@ *'!%'&6"+@ 0&)&)()& *#)&'"@ ;$ !',"$&( 0'&607$,= (
0($"=K")!'. C!$6"#&$K"" ()(K" ;$ *'!*!'K"& /('& 6& +!' (,=#%( '&*(. E6& /(" %'&# ,& !K"$# !
*#)&'& !/!%&$= 07$, #$( ,"$ 0!/*!$&$& &6& ;$ *'!*!'K"& /(" /"0= (K= ,& 0&)&)()&. S& +( (0!',( !
(&$K"& ,&!6&"= '&()"3='"" #$#" (/&6&0 !/!%&$@ /(" ()&6 07$, 6#6($K( ()(= ;$ 0($"=K" /"0" &6&
*#&'$"0 (0"+= 6(# !"0= " 07$, &"6= '"60#) 6#*'(- 6(# 6#,!3='"" 6()&. E6& 0(3#) *#)&'")!' "'(& 1
 6(# 1<@ ;$ 0('& 6#6($K&)& !('& (0"+& 6#$ ,")#(& 0# )(0!3=.

 !',"$&( ,& (/&6&0('& *!(& " 60>"/(= ;$ #$0K"& ,& %'&#(&( 6*&0""0= ( 6#6($K&)!'@ )(
;$0&*#@ 6& (,(#%= 0&)& 0# %'&#(& 6*&0""0= /('&@ "$,"&'&$ ,& 0($"(& 6#$"'(#) (3"0 ,&
"6/# 6& (,(#%= )( ;$0&*#@ "(' !",#) ,& /(%$&3"#@ ;$!,&(#$(@ ;$ "$()@ *&$'# ( &+"( #$&)&
"$&''&(0K"" ;$'& 0!/*!$&$&)& (6!0"(&.
 "$%'&,"&$&)& *'&60'"6& ;$ 0($"=K" /('" 6(# 0('& (# +!)#/ /('& 6& (,(#%= ;$ (/&6&0#) ,&
*#)&'" ;$ /"0" *!'K"#$"@ !/!%&$"37$, "$& 6& ;$0&*& 0# 0&( /(" /"0= 0($"(&@ *&6& 0('& 6&
(,(#%= ! $!#= *!'K"#$& ,& *#)&'&@ 6& (/&6&0= " (*!" 6& (,(#%= #'/=!('&( *!'K"#$&
 6#6($K&)& *#&'$"0 (0"+&@ !"0& " 6#*&"($& 6& (,(#%= ;$ *'&*('(@ ,#*= 0&@ ;$ *'&()(")@
*!'"" /!('#)#" ;$ 0('& 6& '&()"3&(3= (/&6&0('&( 0!/*!$&$&)!'@ (# !6 (0!*&'"K" *'"$
'"#'('&( #$&" 0($"=K" &%()& 6(# ,#)& (K= ,& 6#6($K( *#&'$"0 (0"+= 0# ! *#)&'& "$&'=
*'&60'"6= ;$ '&K&=. P&$'# 0($"=K" !('& /"0" ,& 6#6($K& *#&'$"0 (0"+&@ !"0& " 6#*&"($&
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 6#6($K&)& 0!)!'(& " 0!)!'($& 6& (,(#%= ;$ (/&6&0#) ,& *#)&'"@ ;$ "$()@ (0&6&( "$,"07$,
!!,(= " %'(,#) ,& !/!%&$"(& ( (/&6&0#)#"
 6#6($K&)& >"%'!60!*"0& 6(# &)!'&60&$& 6& (/&6&0= 0# 6#6($K& (6!'($& 6(# "$&'&
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 6#6($K& 6& +!' '"#'( 6&*('( " 6& +!' ,"6*&'6( 0# #$ ,")#($ "$&' " (*!" 6& +!' (/&6&0(@
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(6!'($K" 0(!)"$@ (/",!$@ &$!$"=. $ %&$&'()@ 6& #")"3&(3= ! 0($"(& ,& ,")#($@ &%()= 0#
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)"0>&"&'&(@ 0>"(' 6# *'&6"#$&( ,& 0!/*'"/('& ( #$&" *#)&'"@ $&0&6('= *&$'# !K"$&'&( ()&&)!'.
 6#6($K&)& )"0>",& "$0#'"@ &'(0& )#",&@ &'(0& /!" 6& ,"6*&'6&(3= ;$ *#)&'" (6!'($&

)(0!3=@ ()0@ 0(!)"$@ !", ,& /(%$&3"#@ 0='#$&@ (/",!$@ 0('!$( ,& /(%$&3"#@ !", ,& 3"$0
;$ 0($"(& *7$= )( 1<@ "(' 0&)& /!" *7$= )( :<@ *&$'# ( 6& /&$K"$& 6('&( ,& (%'&%('&
6!)",= ( *'&*('(#)#" 07$, )"0>",#) &6& #$ 6!)+&$ +!)(")@ &) *!(& " &+(*!'( #!'@ *& ("( ,&
(*= ,& &&/*)#@ "$0#'")&@ &'(0&)& )#",& " /!". $ "/*#) &+(*!'='""@ 6& *!(& (,=#%(
)(0!3=@ (&'!6") (/",!$@ 0('!$( ,& 0()0"#@ 0( ,")#($@ *&$'# ( 0'&& +"&3( ,& *"&',&'& (
6!)+&$#)#"@ *'"$ 0'&&'&( ('"&" 6#*'(&K&" ,& &+(*!'('&. A)&!'"@ 6& *!(& #")"3( ! 0($"(&
&0>"+()&$= ,& &'(0 #60( ;$ )!0#) "$0#'"" 6(# &'(0#)#" )#", 6(# /!()&
 #)&"#'")& +!)(")& 6& ,"6*&'6&(3= 0# ! *#)&'& "$&'= (6!'($= !", ,& /(%$&3"# 6(# 3(>='
 6#6($K&)&@ %'(6& 6!)",& 6(# /!" 0&('(@ 6&('"$(@ )($!)"$( 6& !*&60 6(# 6& ,"3!)+= ;$ 6!)+&$K"
+!)(")"@ ,#*= 0('& 6& (/&6&0= 0# *#)&'")& *'&60'"6&@ *7$= )( !/!%&$"3('&( (/&6&0#)#" "
+!)(")"3('&( !()= ( 6!)+&$#)#" ()0!!)@ &&' &")"0
 6#6($K&)& >"%'!60!*"0&@ 0('& 6& ;$/!("& 6& #/&3&60 ,"$ 0(#3( ("$"=K"" *&$'# (*( ,"$ (&'
*! " *'&*('(& 0( *#)&'" ,"+"3(&@ ,(0= 6& (,(#%= ,")#($K" " (6!'($K" "$&'K". P&$'#
*'!&0K"&@ 6& #")"3&(3= 0(*6#)& ,& >7'"& 0&'(= *)"(& ,#)#. S#6($K&)& ,&)"0+&60&$& $# *! "
*'&*('(& 0( *#)&'&
 (/&6&0('&( 0!/*!$&$&)!' 6& 0!$6",&'= &'/"$(=@ 07$, *#)&'&( ('& #$ (6*&0 !/!%&$ "/*
,& (/&6&0('& 1-5 /"$#&. O/!%&$"(&( 6& +&'""0= *'"$ (*=6('&( *"6")#)#" *& 6#*'((K(
*#)&'"". FR 8 "$,"0= +&'""0('&( !/!%&$"=K"" *#)&'"" ;$"$6& ;$ 6'( 6#K"'& *'"$ !6&'+('& 0#
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"$,"0(=@ ;$'#07 0&'$&'&( (+!'"3&(3= 6&*('('&( 0!/*!$&$&)!' "$ *#)+&'"3(& ,& 0&)& /("
*#K"$ *#)+&'"3(&.
 $terilizarea pulberilor - &6& !*&'(K"( ;$7)$"= $#/(" )( *'&*('('&( *#)&'")!' 6&'")&. FR 8
*'&+&,& 6&'")"3('&( !)"%(!'"& *&$'# *#)&'")& *#,'&)& ,&6"$(& ( " (*)"0(& *& *"&)&(
6#%('")!'@ *& *)=%" ,&60>"6& 6(# ('6#'". A0&6& *'&*('(& '&#"& 6= "& 6&'")&. D& (6&/&$&(@
!(& *#)&'")& 0('& 0!$K"$ ($""!"0& 6& +!' *'&*('( *& 0()& (6&*"0=@ *&$'# ( (6"%#'( (7 6&'" -

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 )"(&( *'&*('(#)#"@ 07 " 6(")"(&( ($""!"0#)#"@ ;$ +&,&'&( '&()"3='"" &&0#)#" &'(*&#"0.
S#6($K&)& /&,"0(/&$!(6& " (#")"('& &'/!6(")&@ 0('& "$'= ;$ 0!/*!3"K"( (0&6!' *#)&'"@
6& +!' 6&'")"3( )( &/*&'(#'( "$,"0(=.
M&!,&)& ,& 6&'")"3('& 6& ()&% ;$ #$0K"& ,& *'!*'"&=K")& "3"0!-0>"/"0& ()& /&,"0(/&$&)!' "
/(&'"()&)!' ,& 6&'")"3(@ (6&)
 terilizarea cu aer cald - ;$ &#+& ;$0=)3"& &)&0'"0@ )( T&/*&'(#'( ,& 14<-15< C. U6&$6")&)&@
!"&0&)& ,"$ *!'K&)($ " 6"0)= 6& ;$0=)3&60 < /"$#&@ )( 15< C. L($!)"$(@ +(6&)"$(@ 0&('(@
*('("$(@ *#)&'")& &'/!6(")& 60 ;$0=)3&60 '&" !'&@ )( 14< C@ 6(# ,!#= !'& )( 1< C 
 prepararea pe cale aseptic! 6& (*)"0= !'/#)&)!' 0('& 0!$K"$ 6#6($K& &'/!)(")&. ;$'&%#)
&0>"*(/&$ ,& )#0'#@ 6#6($K&)& &'/!6(")&@ '&0"*"&$&)& +!' "@ ;$ *'&()(")@ 6&'")"3(&@ "('
!*&'(K"( ,& *'&*('('& 6& +( &&0#( ;$ !( 6&'")=. E"0>&( '&0"*"&$&)!' ;$ 0('& 6&
0!$,"K"!$&(3= (0&6& *#)&'" +( *#'( /&$K"#$&( preparat aseptic%
S& *!(& '&0#'%& " )( asocierea cu substan"e conservante%
 U$&)& 6#6($K& &'/!)(")& 0( #'&&@ (0", !'"0@ %)#0!3(@ ($""!"0&)& .(. se sterilizeaz! prin
agitare cu eter sau cloroform, ;$'-#$ +(6 ;$0>"6@ ,#*= 0('& 6& ")'&(3= ;$ 0!$,"K"" (6&*"0&@ ;$
60!*#) ;$,&*='='"" 6!)+&$K")!' +!)(")"@ 0('& (# (0K"#$& ,&6>",'(($= (6#*'( /"0'!!'%($"6/&)!'.
 S&'")"3('&( *'"$ radia"ii ultraviolete 6& (*)"0= '&0+&$ ;$ +&,&'&( *'&%="'"" !&" 6&'")&@
*&$'# 6&'")"3('&( 6#*'(&K&)!'@ ( (&'#)#"@ #6&$6")&)!' " (/()(&)!'@ 0# ! !'= ;$("$& ,&
;$0&*&'&( )#0'#)#". P#)&'")& ,& #3 &&'$ *! 0!$K"$& 6#6($K& ($"6&*"0& (*'!(& ,&
M"$"6&'#) S=$==K"" *& &"0>&( *'&*('(#)#" 6& +( /&$K"!$( $(#'( " 0!$0&$'(K"( (0&6!'(.
 %i!izarea pulberilor - ,#*= !*&'(K"")& ,& 07$='"'&@ *#)+&'"3('&@ 0&'$&'& " (/&6&0('& (
0!/*!$&$&)!'@ #$&)& *#)&'" 6& '&*('"3&(3= ;$ '&0"*"&$#) ,& 0!$,"K"!$('& " (*!" 6&
(/()&(3=. A0&6& *#)&'" 6"/*)& 6(# 0!/*#6& 6& *'&*('= nedivizat1 ()& *#)&'" 6& ;/*(' ;$
doze unitare 0('& 6& 0!$,"K"!$&(3= 6&*('( " (*!" 6& (/()&(3= ;/*'&#$=.
P#)&'&( $&;/*='K"= ;$ ,!3& 6& (,/"$"6'&(3= *'"$ /=6#'('& (*'!"/("+= 0# +7'#) ,& 0#K".
U$&)& *'!,#6& '&()"3(& ;$ "$,#6'"& C(6&!)(0@ L&0""$=@ S('& ='= 6!,"# (# ;$ (/()( " ! )"$%#'"K=
,!3(!('&. E'!'")& 6#$ ,&6#) ,& /('"@ ""$, ! (*'&0"&'& ,#*= +!)#/. S# !'/= $&,"+"3(= 6& *'&*('=
/(!'"(&( *#)&'")!' ('/(0&#"0& *&$'# #3 &&'$ 6(# *#)&'")& !)!6"& "$&'$ 0('& 0!$K"$ 6#6($K&
($!,"$&  0='#$&@ *'!,#6& +&%&()&@ 6#6($K& ($"(0",&.
O*&'(K"( ,& ,"+"3('& ( *#)&'")!' 6"/*)& 6(# 0!/*#6&@ ;$ ,!3& #$"('&@ ('& 0( 60!* ;/*='K"'&(
*#)&'"" ;$ 0($"=K" &(0& 2doze0, $&0&6('& (,/"$"6'='"" *& 0()& "$&'$= " #$&!'" *&$'# (*)"0(K""
&&'$&.
M(!'"(&( *#)&'")!' ,"+"3(& 6#$ ,& #3 "$&'$. E)"&'('&( ;$ ,!3& #$"('& *'&3"$= (+($(#)
(6"%#'='"" #$#" ,!3( 0!'&0 " (/&)"!'&(3= 0!$6&'+('&( *'&*('(#)#"@ ;$ *)#6@ *'"$ "$'!,#0&'&( ;$

15
0(*6#)& (/")(0&& 6(# %&)("$!(6&@ 0('& 6& ;$%>" !,(= 0# *#)&'&(@ 6& *!(& /(60( %#6#) 6(# /"'!6#)
$&*)=0# () #$!' 0!/*!$&$&.

D"+"3('&( *#)&'")!' 6& '&()"3&(3= *'"$ '&" *'!0&,&&@ ;$ #$0K"& ,&

• /(6( ,& *#)&'& 
•
+!)#/
• *'"$ (*'&0"&'& +"3#()=.
P&$'# !K"$&'&( #$&" *'&0"3"" /('" ;$ ,!3('&( *#)&'")!'@ 6& '&0#'%& la c3nt!rirea fiecarei
doze la
()($K( ( 0='&" 6&$6"")"(& &6& ;$ 0!$0!',($K= 0# '&6*&0"+( 0($"(& ( ,!3&" #$"('&. C7$='"'&(
"&0='&" ,!3& ;$ *('& (6"%#'= #$"!'/"(&( /(6&" "/*#6& ,& ('/(0!*&&. A0&(6= /&!,= (6"%#'= 0&(
/(" /('& &(0"(&@ ,(' *'&6#*#$& #$ "/* /(" ;$,&)#$%( ,& )#0'#. M&!,( 6&'+&& *&$'# ,"+"3('&(
;$'-#$ $#/=' /"0 ,& ,!3&.
$ +&,&'&( ,"+"3='"" #!('& ( 0($"=K")!' /('" ,& *#)&'" 6& #")"3&(3= dispozitive de dozare

reglate dup! volumul de pulbere *& 0('&-) !0#*= ,!3( #$"('= )"$%#'"K( 6(# !('&0&)& ,& ,"+"3('&@
*'&+=3#= 0# ! 0#*= 0('& 0#*'"$,& +!)#/#) ,& *#)&'& " #$ 6"6&/ ,& *7'%>""@ () 0='#" '(K ;$)=#'=
&0&6#) ,& *#)&'&.
$ *'(0"0( ('/(0&#"0=@ 6& !)!6&& '&0+&$ *&$'# ,"+"3('&( *#)&'")!' 0&( ,&-( '&"(
/&!,=  *'"$ aprecierea vizual! ( +!)#/#)#"@ 0('& '&*'&3"$= ,!3( #$"('=@ ,"6'"#"= *& 0('&)& ,"$
0&)#)!", 6(# /(&'"() *)(6"0. P&$'# ( (+&( &'!'" 07 /(" /"0"@ 6& +!' 07$='" )( ()($K=@ ;$ *'&()(")@ #$
$#/=' ,& ,!3&@ ,#*= () 0='!' +!)#/ 6& +!' (*'&0"( 0&)&)()& ,"+"3='"@ *#)&'&( 6& ,"6*#$& 6# !'/= ,&
0!$#'"@ *'"$ 0#'%&'& *& 0('&)&. C('&)&)& (# ! )&"")"(& 0!'&6*#$3=!('&@ *&$'# ( *&'/"&
0!$,"K"!$('&( ,!3&)!'. U$&)& 0('&)& 6#$ *'&+=3#& 0# #$ 0"!0 0('& (0")"&(3= ,&60>",&'&( 0(*6#)&)!'
,& >7'"&@ ()&)& (# "/*'"/(& ! 6&'"& ,& 0&'0#'" 0!$0&$'"0&@ *'&6#*#$7$, 0= ,!3& &%()& ,& *#)&'&
!0#*= +!)#/& &%()&.
P&$'# ( 6& (6"%#'( ! *'&0"3"& ( ,!3='""@ &6& $&0&6(' 0( /(6( #$&" ,!3& #$"('& ,& *#)&'& 6= $#
"& 6# <@2< %. D(0= &6& $&+!"&@ 6& *!(& (,=#%( 0( ,")#($@ )(0!3=. $ /!, #3#()@ /(6( #$&" ,!3& ,&
*#)&'& ('& +()!'" ,& <@2<-<@< %. L( ;/*='K"'&( ,!3&)!' ,#*= +!)#/@ *! 6= (*('= &'!'" ,"$ 0(#3(
*'!*'"&=K")!' '&!)!%"0& ()& *#)&'")!' )#","(&@ (,&3"+"(&@ ,&$6"(& (*('&$=.
+eguli practice de divizare a pulberilor:
 ;$ 60!*#) /"0!'='"" &'!'")!' )( ,"+"3('&@ (/&6&0#) ,& *#)&'" 6& ;/*('& *'"$ 07$='"'& ;$ 0"$0"

6(# /("/#/ 3&0& ,!3&@ 0('& #'/&(3= 6= "& ,"+"3(& *'"$ (*'&0"&'& +"3#()=@ *& 0('&)&
 0('&)&)& 6& ,"6*#$ ;$ '7$,#'" +&'"0()& 6(# !'"3!$()&@ ,& )( 67$%( )( ,'&(*(@ 07&  6(# 1<@
#$&)& *&6& ()&)&@ "&0('& 0('&)= ""$, (0!*&'"= ,& 0('&)( #'/=!('&
 ,"+"3('&( *#)&'"" 6& '&()"3&(3= ! 0# ! 0('&)=@ 0('& 6& K"$& ;$ /7$( ,'&(*= *#)&'&( &6&

19
 '&*('"3(= *& 0('&)& *'"$'-! #!('= )!+"'& ( 0('&)&" 0# *#)&'&@ 0# ,&%&#) ('==!'
 *#)&'&( ,& ,"+"3( 6& '&*('"3&(3= /(" (*'!(*& ,& 0(*=#) 0('&)&"@ " $# )( /")!0#) 0('&)&"@
*&$'# ( &+"( *"&',&'")& ,& 6#6($K=@ )( "$'!,#0&'&( ,!3&)!' ;$ (/()(&
 $# 6& (,/"& ,"+"3('&( ( ,!#= ,!3& *& ! 0('&)=
 *&$'# /"0!'('&( &'!'")!' ;$ %'&#(& 6& "$,"0= ,"+"3('&( ,&!,(= ( #$#" $#/=' /"0 ,& ,!3&
1<@ 0&) /#) 2<
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;$'& &)&@ ;$'#07 (*'&0"&'&( +"3#()=@ 0!/*('("+= ( +!)#/&)!' ,& *#)&'& &6& /(" ,""0")=
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,"+"3('& " 0!$,"K"!$('& ;$ (/()(&
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/(6( ,& *#)&'& ,"+"3(=

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(0!*&'"'&( (0&6!'( 0# #$ 6'( !('& "$ ,& *('("$= 6!)",= 0('&)& 0&'(&@ (/()(& *#$%" "
0(*6#)& ,& >7'"& 0&'(& 6(# *&'%(/"$(&
 ,#*= &'/"$('&( !*&'(K"&" ,& ,"+"3('&@ 0('&)&)& 6& &'% ,& *'( 0# "!$ 6(# +(= 0# ()0!!) " 6&
,"6*#$ ;$'-#$ *(>(' B&'3&)"#6@ *&$'# (-" *=6'( !'/( ,& %&(.
 Condiţionarea #i ambalarea pulberilor - !*&'(K"( 0('& #'/&(3= ,"+"3='"" &6& 0!$,"K"!$('&(
*#)&'")!'. P#)&'")& $&,"+"3(& 6& &)"&'&(3= ;$ 0#"" ,"$ (/"$!*)(6@ !'0($& ,& 6"0)=@ *#$%" ,&
>7'"& 6"/*)= 6(# 0&'(=@ *& 0('& 6& "$,"0= /!,#) ,& (,/"$"6'('&@ $#/='#) ,& !',"$& ,"$
'&%"6'#) ,& 0!*"&'& ( '&K&&)!'@ ,(( " #$"(&( ;$ 0('& 6-( &&0#( *'&*('('&( /&,"0(/&$#)#"@
6&/$=#'( *'&*('(!'#)#" *#,'&)& 6&'")& 6& +!' 0!$,"K"!$( ;$ '&0"*"&$& 6&'")"3(&.
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• +7'#) ,& 0#K"@ 0('& 0!'&6*#$,& )( (*'!"/("+ <@-1 % 
• )"$%#'"K( '(6=@ (*'!"/(= )( 2-4 % "
• )"$%#'"K( 0# +7'@ )( 4- %.

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0(*6#)& %&)("$!(6& )('"@ 0#"" ,"$ (/"$!*)(6 6(# )(0!($& ,"$ 6"0)=. C(*6#)&)& ,& >7'"& 6& ()&% ,#*=
+!)#/#) ,!3&" ,& *#)&'& 6& ,&60>", 0# /7$( *'"$ (*=6('& #!('=. S& *! #")"3( " ,"6*!3""+& ,&
,&60>",&'& 6*&0"()=. N# 6& (,/"& ,&60>",&'&( 0(*6#)&)!' *'"$ 6#)('& 0# %#'(. D#*= #/*)&'&( 0#
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07& : 6(#  " 6& "$'!,#0 ;$ *#$%" ,& >7'"& 6(# 0#"" ,"$ (/"$!*)(6@ *& 0('& 6& 6*&0""0= (0&)&("
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$!='" 0( " ;$ 0(3#) *#)&'")!' $&,"+"3(&.
Capsulele amilacee 0(ș&&@ #)"$ & 6& #")"3&(3= '&0+&$ *&$'# '&*(' "3('&( ,!3&)!' #$"('&
!K"$#& *'"$ ,"+"3('&( *#)&'")!' *& 0('&)& ,& 0&)#)!",. N#/='#) 0(*6#)&" (/")(0&& 6& 6&)&0&(3= ;$
'(*!' 0# '&6*&0"+( 0($"(& ,& *#)&'& 0('& 6& *!(& "$'!,#0& ;$ &(. C(*(0"(&( 0(*6#)&)!' (/")(0&&
&6& ,&*&$,&$= " ,& ,&$6"(&( *#)&'"". P#)&'")& 0# +!)#/ /('& (K= ,& 0(*(0"(&( 0(*6#)&" 6#$

#$&!'" *'&6(& 0# #$ *"6!$ 6(# ,!*.

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,"+"3(= *& 0('&)& ,& 0&)#)!",. N# &6& *&'/"6= ,"+"3('&( ,"'&0=@ ;$ 0(*6#)&)& (/")(0&&@ ,&!('&0&
0!$,#0& )( &'!'" ,& %'&#(& !('& /('". S& "$'!,#0 ;$ *#$%" ,& >7'"& 6(# 0#"" ,"$ (/"$!*)(6 " 6&
(*)"0= &"0>&(.
$ ('/(0"")& ,& 6*"() " *!)"0)"$"0= ('/(0"" ,& 0"'0#" ;$0>"6@ /(" ()&6@ *#)&'")& ,"+"3(& 6#$
'&*('"3(& ,"'&0 ;$ capsule gelatinoase operculate tari, 0# (#!'#) #$#" (*('(. E)& 6#$ ,&60>"6&@ (*!"
6#$ (/()(& ;$ !)"" ,& ()#/"$"# " 6"%")(& )( 0(), &+&$#() "$60'"*K"!$(&@ 0# ,&$#/"'&( *'!,#6#)#"
" &'/&$#) ,& +()(")"(&.
 Păstrare. &liberare din farmacie - *#)&'")& 6& *=6'&(3= ;$ ('/(0"& )( )!0 #60(@ '=0!'!6@ &'"

,& )#/"$=@ ;$ +&,&'&( &)"&'='"" )( !)$(+. S& *'&*('= )( $&+!"&. E)"&'('&( /&,"0(/&$#)#" &6&
;$6!K"= 0# 6(#'" " "$,"0(K"" ,(& *(0"&$#)#"@ *'"+"$, /!,#) ,& (,/"$"6'('& " ,& *=6'('& (
(0&6#"(.

'.).PREPARAREA PULBERILOR ÎN INDUSTRIE.

$ 0($"=K" /('"@ *& )!#'" 6(# ('& ,& ('"0(K"&@ *#)&'")& 6& *'&*('= ;$ "$,#6'"( ,&
/&,"0(/&$&@ "& 6# !'/= $&,"+"3(=@ "& ,"+"3(=.
F(K= ,& ()& !'/& ('/(0&#"0&@ "$,#6'"( ,& /&,"0(/&$& *'&*('= #$ $#/=' /"0 ,& *'!,#6&
6# !'/= ,& *#)&'".
pa"ii de produc"ie
F('"0('&( *#)&'")!' 6& &&0#&(3= ;$ 6*(K"" ,& *'!,#0K"& ,&6"$(& $#/(" (0&6!' !'/&  (0&6&
6*(K"" 6#$ 0!/*('"/&$(& *& (3&)& ,& )#0'# #60('&@ /='#$K"'&@ *#)+&'"3('&@ 0&'$&'&@ (/&6&0('& "
!/!%&$"3('&@ ,"+"3('&@ 0!$,"K"!$('& " (/()('&@ 0!$'!)#) 0()"=K""@ ,&*!3"('& " &*&,"K"&.
Z!$&)& ,& )#0'# '&#"& 6= "& *'&+=3#& 0# 6"6&/& ,& ,&6*'=#"'&@ "(' !*&'(!'"" '&#"& 6= "&

&0>"*(K" (,&0+(@ *&$'# ( $# "$>()( *('"0#)&)& ,& *#)&'& 0&,(& ;$ (/!6&'= " ( $# 6#&'" "$!"0(K""
;$ 0(3#) *'!0&6='"" ,& 6#6($K& ,& )( „S&*('($,( 6(# „V&$&$(.

*chipament de produc"ie

21
 F"&0('& 0!/*('"/&$ &6& 0!$6'#" 0!$!'/ "$,"0(K"")!' ,"$ „R&%#)")& ,& #$= *'(0"0= ;$
('"0(K"&” " &6& *'&+=3# 0# &0>"*(/&$#) ,& *'!,#0K"& $&0&6(' !*&'(K"&" ('/(0&#"0& 0('& 6& +(
&&0#(
• 6"6&/& ,& /($"*#)('& " '($6*!' *&$'# /(&'"")& *'"/&
• ,"6*!3""+& ,&  /='#$K"'&@ 0&'$&'&@ (/&6&0('&
• ,"6*!3""+& ,& ,"+"3('& " '&*('"3('& ( *#)&'")!' ,"+"3(& 6(# $&,"+"3(& ;$ ('"0!)&)& ,&
0!$,"K"!$(& " (/()('& 
• (*('(& ,& #60('&.
+ecipiente 4i articole de condi"ionare
P#)&'")& ,& #3 !'() 6& (,/"$"6'&(3=@ ;$ %&$&'()@ 0# (*= 6(# 0# #$ () )"0>", (,&0+( ;$ *#K"$&
0(3#'"@ *#)&'&( 6& ;$%>"& 0( (('&.
P&$'# (0&6 60!*@ 6#$ ,"6*!$ "")& pulberi monodoz! 6(# ,"+"3(& ;$ ,!3& /#)"*)& - pulberi
multidoz!%
" *&$'# #3 &&'$@ *& *"&)& 6(# /#0!(6&@ 6& *! ;$7)$" (/&)& "*#'" ,& *#)&'& - ,"+"3(& 6(#
$&,"+"3(&. $ "$,#6'"&@ ,"+"3('&( " 0!$,"K"!$('&( *#)&'")!' 6& &&0#&(3= (#!/(. P&$'#
0!$,"K"!$('&( " (/()('&( *#)&'")!'@ 6& #")"3&(3= ,"&'"& "*#'" ,& ;$+&)"#'" " '&0"*"&$& 
• pungi de hrtie simpl! sau cerat! >7'"( $# (6"%#'= *'!&('&( *#)&'")!' (K= ,& (%&$K" &&'$".
P'"$ (*)"0('&( #$!' 6'(#'" ,& 0!/"$(K"" /(0'!/!)&0#)('&@ *'"$ 0&'#"'& 6(# *('("$('& !'" *'"$
(0!*&'"'& 0# /&()&@ 6& ;/#$==K&60 *'!*'"&=K")& ,& *'!&0K"& ()& >7'"&"
• pungi din plastomer opac  (0&6&( 6#$ &)(6"0&@ '&3"6&$& ,"$ *#$0 ,& +&,&'& /&0($"0 "
"/*&'/&(")&@ *'&3"$= #$ (/()( 0!'&6*#$3=!' *&$'# /#)& *#)&'". P#$%")& 6& *! 6#,( ;$

0(3#) 0!$,"K"!$='"" #$&" 6"$%#'& ,!3& 6(# 6& *! ;$0>",& *'"$ '=6#0"'&( 0(*=#)#" " (6"%#'('&(
;$0>",&'"" 0# (#!'#) #$&" &$3" ,& )"*" '($6*('&$& 6(# ( #$&" &$3" /&()"0&
• sacii de polietilen! 6(# ,& clorur! de polivinil, #")"3(K" *&$'# *=6'('&( *#)&'")!' ;$ +'(0@ 6&
"$'!,#0 ;$ )=3" ,& )&/$ 6(# ;$ 0#"" ,& 0('!$ 6(# ,& ()=. A/()(&)& ,"$ 0('!$ *&$'# *#,'&
6& ;$)!0#"&60 ! /(" /#) 0# '&0"*"&$& 6(# 0#"" ,"$ /(&'"() *)(6"0@ )&"")&. D"$ (6&/&$&(
(/()(&@ *#)&'&( &6& &'(6= *'"$'-#$ 6"$%#' !'""0"#@ *'"$ (*=6('& *& *&'&K" " 6& *!(& '&%)(
0($"(&( ,& /&,"0(/&$ (,/"$"6'(
• flacoane de sticl! 6(# cutii metalice inoxidabile 1
R&0"*"&$&)& 0# *#)&'" $&,"+"3(& 6#$ ;$6!K"& ,& ! /=6#'= ,& &)"&'('& ( ,!3&" "$"K"() 6-(
#")"3( ! )"$%#'"K= !"$#"=. D('@ ,"$ 0(#3( ,"&'&$K&" ;$ /='"/&( " !'/( )"$%#'"K&)!' #")"3(& ,&
;$'&(%( )#/&@ 07 " ,"$ 0(#3( ,&$6"=K"" *#)&'")!'@ #/","=K""@ %'(,#)#" ,& (6('& 6(# (*=6('&@ 07 "
(*'&0"&'"" *&'6!$()& ( *(0"&$K")!' 0('& 6&)&0(# ! )"$%#'"K= *)"$= 6(# $#/(" *& #/=(& 6-( ,&0"6 6= 6&
#")"3&3& ()& ,"6*!3""+&.
22
 A0&6&( 6#$@ ;$ %&$&'()@ )"$%#'"K& ,& /=6#'('&@ ,"$ *)(6!/&' !*(0 6(# '($6*('&$@ %'(,(& ;$
,"+"3"#$" *& *&'&K"" "$&'"!'" " 0('& 0!'&6*#$, %'&#=K"" *#)&'""@ ;$ #$0K"& ,& ,&$6"(&( (0&6&"(
• (/()(& /!, &'$& 0#/ 6#$  sa4etele '. sachet " 6=0#)&K sau plicule"ele ,"$ ()#/"$"#@
*)(6!/&' !*(0 6(# >7'"& 0=*#"= 0# *!)"/&' 6(# /(&'"()& 0!/*)&&  *)(6!/&' 0# ()#/"$"#.
F!)"( ,& ()#/"$"# 6(# >7'"& &6& (0!*&'"= *& #$( 6(# *& (/&)& *='K" "$&'$= "6(# &&'$= 0#
*!)"&")&$=@ PVC. S(&&)& 6& *! 6#,( )( 0(),@ ,"'&0 (0&6&( 6#$ sa4etele termosudabile 6(# 6&
)"*&60 *'"$ "$&'/&,"#) )(0#'")!'.
A0&6&( (6"%#'= ! #$= 0!$6&'+('& " ! #!('= ,"6'"#"'& " '($6*!'. ;$ /!/&$#)
(,/"$"6'='""@ *)"0#'")& 6#$ ,&6=0#& )( )!0#) /('0( " ,#*= *'&)&+('&( 0!$K"$##)#"@ 6& ('#$0= 6& *!
!)!6" " 6(&& 0# ,!#= 0!/*('"/&$& !K"$#& *'"$ 6#,('& /&,"($= ;$ /!/&$#) !)!6"'""@ *'"$
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6(# *'&( /"0= *!(& '&,#0& 6&/$""0("+ &"0"&$K( !/!%&$"3='"".
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,& !'&0('&
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6= (6"%#'& ! ,&60='0('& !()= ( *#)&'"". A0&(6( +( '&,#0& '"60#) ,& 0!$(/"$('& "@ !!,(=@
+( *'!&( !*&'(!'#)@ ,& "$>()('& ( *'!,#6#)#"
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6#*'(&K&)& 0!$("$&'#)#".
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24
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 pulberile divizate 6& '&*('"3&(3= 0# /("$" (#!/(& ;$
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)(#'"@ "$'!,#0&'&( *#)&'"" ,"+"3(& 0# ,!3(!('& +!)#/&'"0& /(" '(' *!$,&'()& " ;$0>",&'&( &($=
*'"$ 6#,('&( #)"/&" )(#'". P#)&'")& 6#$ (,=#%(& 0# ,"6*!3""+& ,"&'"&@ 0#/ (' "  /"0'!*"6!$@
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25
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