TEACHING AND

CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION

STRATEGIES MATERILAS PROCEDURE OF VALUES
A. GENERIC NAME:
 Ranitidine

B. BRAND NAME:
 Zantac 1min

C. CLASSIFICATION:
 Histamine H2
Antagonists

D. MECHANISM OF ACTION:
Ranitidine is a competitive inhibitor
of histamine H2-receptors. The
reversible inhibition of H2-
receptors in gastric parietal cells
results in a reduction in both gastric
1min
acid volume and concentration.
Ranitidine’s acid-lowering effect is
more pronounced for basal and
nocturnal acid secretion than it is
for food-stimulated acid secretion.
Additional indirect effects of
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES
ranitidine are decreased pepsin
secretion and increased nitrate-
reducing bacterial flora

E. ROUTE/DOSAGE:
Active Duodenal or Gastric ulcer:
(1MOS- 16YEARS)
• For tx: 4-8mg/ kg PO bid.
Maximum of 300 mg a day.
• For maintenance: 2-4 mg/kg
PO once a day. Maximum of
150 mg per day.
• IV: 2-4mg/kg day IV in 6-8 3mins
hrs divided doses. Maxmum:
50 mg/dose or 200 mg/day
• GERD or erosive
esophagitis
term neonates: 2-4
mg/kg/day PO in 8-12 hrs
divided doses or 2 mg/kg/day
IV in 8 hourly divided doses.
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES

• 1mos – 16 years: Oral: 5-

10mg/kg/ day PO divided into
bid. Maximum 300 mg/day.
• IV: 2-4 mg/kg/day IV in 6-8
hourly divided doses.
Maximum of 50-200mg/day;
alternatively, 1mg/kg/dose
infusion once follomg/kg/ day
continuous infusion.

F. INDICATION:
• Gastric ulcer
• Hyperacidity 3mins
• GERD
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES

G. ADVERSE EFFECTS :
• diarrhea
• fatigue
• headache
• insomnia
3mins
• Stomach discomfort or pain,
• nausea
• vomiting
• constipation
H.CONTRAINDICATION:

 patients known to have

hypersensitivity to the drug
or any of the ingredients. 3mins
Acute porphyria, Treatment
with ranitidine may mask
the symptoms of other gastric
disease, Raised liver
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES
 enzymes may occur with
high doses.

I. PREGNANCY CATEGORY:
 Pregnancy Category B
J. INTERACTIONS:
 Delavirdine: Do not take
delavirdine with
ranitidine. Doing so can
cause dangerous effects.
Ranitidine reduces the levels
of delavirdine in your body.
This means delavirdine 5mins
won’t work as well.
 Procainamide: Taking high
doses of ranitidine with
procainamide can cause side
effects from procainamide.
 Warfarin: Taking ranitidine
with warfarin may increase
your risk of bleeding or
blood clots. Your doctor may
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES
watch you more closely if you’re
taking these drugs together
 Midazolam and
triazolam: Taking ranitidine
with either of these drugs
raises your risk of extreme
drowsiness that can last a
long time.
 Glipizide: Taking these
drugs together can increase
your risk for low blood
sugar. You may need to test
your blood sugar or test it
more often when starting or
stopping ranitidine.
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES

K.NURSING IMPLICATIONS:
Assessment
◍ History: Allergy to ranitidine,
impaired renal or hepatic
function, lactation, pregnancy
◍ Physical: Skin lesions;
orientation, affect; pulse,
baseline ECG; liver evaluation,
abdominal examination,
6mins
normal output; CBC, LFTs,
renal function tests
◍ Interventions
◍ Administer oral drug with
meals and at bedtime.
◍ Decrease doses in renal and
liver failure.
◍ Provide concurrent antacid
therapy to relieve pain.
◍ Administer IM dose undiluted,
deep into large muscle group.
◍ Arrange for regular follow-up,
including blood tests, to
evaluate effects.
 TEACHING AND
CONTENT T/A SPECIFIC OBJECTIVES LEARNING INSTRUCTIONAL EVALUATION INTEGRATION
STRATEGIES MATERILAS PROCEDURE OF VALUES
Teaching points
◍ Take drug with meals and at
bedtime. Therapy may continue
for 4–6 weeks or longer.
◍ If you also are using an antacid,
take it exactly as prescribed,
being careful of the times of
administration.
◍ Have regular medical follow-up
care to evaluate your response.
◍ You may experience these side
effects: Constipation or diarrhea 5mins
(request aid from your health
care provider); nausea, vomiting
(take drug with meals);
enlargement of breasts,
impotence or decreased libido
(reversible); headache (adjust
lights and temperature and avoid
noise).
◍ Report sore throat, fever, unusual
bruising or bleeding, tarry stools,
confusion, hallucinations,
dizziness, severe headache,
muscle or joint pain.