Homework : Di George syndrome & the CO MT gene .

Summary -

Di George
Dia e is caused by a small
orge syndrome the deletion of segment of chromosome 22
-

Also known 22 all 2 deletion syndrome

-

as

symptoms vary though often congenital heart problems specific facial features
include
-

, ,

frequent infections ,
developmental delay learning problems & cleft palate
,
.

Associated conditions include kidney problems low & Auto immune

hearing
-

disorders such as rheumatoid arthritis & a raves disease .

Occurs usually due to the deletion of 30 -

40 genes in the middle of chromosome

22 , with 90% A cases occurring due to a new mutation during e
any
development , and 10% inherited from parent a -

children with Diaeorge 's are a specifically high risk group for developing
-

Saro phren ca about 30% have at least one incident of

psychosis 8 About
'
-

Hu develop actual scieopnrenia .

Summary : The co MT acne

Responsible for an
enzyme known as cachet or O Methyltransferase
making
- - -

which breaks down catecholamines (stress neurotransmitters ) .

In
doing this the co MT Gene directly responsible for bringing your heartbeat
-

. is

down & restoring a sense of balance to

your psychological & physiological self
.

the co MT
gene is
extremely variable about 80% of the population has a genetic
-
-

variant on this
gene
prefrontal cortex brain requires signalling
-

the in the
gene is active zone of the , which

by dopamine to function efficiently CONT helps to maintain appropriate levels

-

of dopamine in the brain .

Variable co MT
gene
=
Abnormal levels of dopamine = More likely to develop
Scioto phrenic
according
to dopamine hypothesis ?