Scientific Research II Lit Review Matrix
Article Title & Link Theoretical/Conceptual
(Add APA citations below
matrix
Using www.citefast.com)
Maternal germ-line
transmission of mutant
mtDNAs from embryonic
stem cell-derived
chimeric mice.
https://www.ncbi.nlm.nih.g
ov/pmc/articles/PMC18941/
# &
Combining drug and music
therapy in patients with
moderate Alzheimer's
disease: a randomized
study.
https://eds-a-ebscohost-
com.proxygsu-
scob.galileo.usg.edu/eds/de
tail/detail?vid=0&sid=074f
bdfb-26cb-4b3e-afdd-
1728c4206061%40sdc-v-
sessmgr01&bdata=JnNpd
GU9ZWRzLWxpdmUmc2
NvcGU9c2l0ZQ%3d%3d#
AN=129755462&db=pbh
Research Methodology Analysis & Results Conclusions Implications for
Framework Question(s)/Hypothesis Future Research
Example
Previous studies have Can mtDNA embryonic 1. Embryonic CAPr mtDNA can be This new method This procedure
introduced mtDNA stem cells be introduced stem cell transmitted through makes it possible can now be used
mutations into whole- into female mice in such a culture & maternal germ line; to introduce to study several
animal systems but not in way that it will then be cybrid however, the pups did mouse mtDNA new mtDNA
such a way that these inherited in subsequent preparation. not live beyond into female germ mutations.
mutations are then maternal germ lines? 2. Production neonatal period. line via somatic
inherited via maternal & cells, resulting in
lineage in subsequent Genotyping inheritance in
generations. of Chimeric subsequent
generations.
Transgenic
Mice
3. Pathological
analysis
4. Electroretino
-graphy
Cholinesterase inhibitors How do these two 1 Patients with There was not a Patients who This procedure
and memantine are two treatments compare and AD were significant difference in receive the can now be used
drugs that have proven to what happens if you selected and sent the groups who only combined to study the effect
have a small effect on combine the two? for a follow up received one type of treatment have of even longer
cognitive ability in patients appointment treatment. As the benefits in the studies.
with AD, but not much in 2 After treatment went on, the psycho-
social life, communication prescreening, results got better in the behavioral
or caregiver burden. Active patients groups with combined profile, but not as
music therapy has shown underwent treatments. much in the
mild decrease in memory baseline testing cognitive
lapses, anxiety, and and were approach.
depression. randomly
assigned a study
group
3 Add
medication and
music therapy to
each group and
examine results

An investigation into the
short-term effects of music
therapy for patients with
probable Alzheimer’s
disease or another form of
dementia.
https://eds-a-ebscohost-
com.proxygsu-
scob.galileo.usg.edu/eds/de
tail/detail?vid=0&sid=25c
d57ad-3c60-4f1c-a56a-
9fa263ed816c%40sdc-v-
sessmgr02&bdata=JnNpd
GU9ZWRzLWxpdmUmc2
NvcGU9c2l0ZQ%3d%3d#
AN=edsdoj.3ab69a8cf0e94
e37bc38c143dc557bb3&db
=edsdoj
EFFECTS OF A 12-WEEK
AEROBIC EXERCISE
PROGRAM COMBINED
WITH MUSIC THERAPY
AND MEMORY
EXERCISES ON
COGNITIVE AND
FUNCTIONAL ABILITY
IN PEOPLE WITH
MIDDLE TYPE OF
ALZHEIMER'S DISEASE
Scientific Research II Lit Review Matrix
Alzheimer’s disease is a How can music therapy 1 4 participants The daily life test Although there What happens if
progressive disease that affect the mind of an AD made up the showed no was no cognitive the sessions are
eventually leads to death. patient? group of women improvement, in improvement, done daily instead
There is no cure, but music being tested caregiver and patient there was of weekly?
therapy is a precaution that 2 Administer levels. The patients improvement in
can be taken against it. standardized who had already been the patient’s
testing at the participating in some mental state and
beginning of the form of therapy already involvement in
study had lower levels than the therapy.
3 After the the ones with out.
sessions of music
therapy have
started, re-
administer
standardized
testing again
4 Examine how
the scores differ
Alzheimer’s represents What if the three of these 1 Collect a group The aerobic exercise This was shown How can this
60% of all dementia cases. treatments were of 30 combined with the to delay information be
Patients often go through combined? Alzheimer’s music therapy helped deterioration of used in other
exercise therapy, music patients (second the patient’s cognitive the mind caused studies?
therapy, and memory stage) and have and functional ability. by AD.
therapy separately. them perform
memory and
cognitive
standard tests
2 Have the
patients perform
30 minutes of
aerobic exercise
and 10 minutes
of music and
memory therapy,
three times a
week
3 Give
standardized
tests at the end of
study.

The Use of Music and
Music Therapy in
Ameliorating Depression
Symptoms and Improving
Well-Being in Nursing
Home Residents With
Dementia
https://eds-a-ebscohost-
com.proxygsu-
scob.galileo.usg.edu/eds/de
tail/detail?vid=0&sid=519f
095c-de05-46b8-9867-
163489d01484%40sdc-v-
sessmgr01&bdata=JnNpd
GU9ZWRzLWxpdmUmc2
NvcGU9c2l0ZQ%3d%3d#
AN=edsdoj.3f8addddefd84
bcd97926
Music Therapy Using
Singing Training
Improves Psychomotor
Speed in Patients with
Alzheimer's Disease: A
Neuropsychological and
fMRI Study
https://www.karger.com/A
rticle/FullText/436960
Scientific Research II Lit Review Matrix
Very few studies have How will the results 1 Administer 2 A significant Depression Can music
shown the influence of found by CNAs be weeks of music improvement was symptoms therapy designed
music intervention led by different than normal therapy found in the patients decreased over by professionals
certifies nursing assistants results? 2 Administer 2 mental state over the the first 2 weeks, be better for
trained by music therapists. weeks of music four week testing and stabilized patients in nursing
activities period over the next homes than
(singing, music two. The people traditional music
with movement) who participated therapy?
3 Measure the in the singing
psychological intervention had
state of the their wellbeing
patients improved slightly
Though music therapy is Can music therapy affect 1 Perform group Participation was Patients that had Why did the
often used in many the brain in a cognitive singing therapy successful. A not been able to activity of daily
hospitals and nursing way that can be seen on at a hospital once prolongation of the perform multiple life score decrease
homes, there is a clear lack an fMRI? a week for 6 patients sleep time was tasks in the but the patients
of scientific evidence. months (voice reported, and their experiment were cognitive function
More studies using training, former scores were lowered on able to perform did?
appropriate methodologies session songs, all tests given. multiple at the
and an understanding of familiar songs end of it.
the precise effects music from youth or
therapy has on cognitive recent days)
processing are greatly 2 Before and
needed. after the
sessions, carry
out the Raven’s
Colored
Progressive
Matrices test for
out of 15 points
3 Before and
after the music
therapy, perform
fMRIs
 Scientific Research II Lit Review Matrix
Citations
Example

Sligh, J. E., Levy, S. E., Waymire, K. G., Allard, P., Dillehay, D. L., Nusinowitz, S.,Wallace, D. C. (2000). Maternal germ-line transmission of mutant mtDNAs
from embryonic stem cell-derived chimeric mice. Proceedings of the National Academy of Sciences, 97(26), 14461-14466. doi:10.1073/pnas.250491597
Clute. O. The Young Researcher. (2017). An investigation into the short-term effects of music therapy for patients with probable Alzheimer’s disease or another
form of dementia. Retrieved from http://www.theyoungresearcher.com/papers/clute.pdf
Giovagnoli, A. R., Manfredi, V., Schifano, L., Paterlini, C., Parente, A., & Tagliavini, F. (2018). Combining drug and music therapy in patients with moderate
Alzheimer’s disease: a randomized study. Neurological Sciences, 39(6), 1021–1028. https://doi-org.proxygsu-scob.galileo.usg.edu/10.1007/s10072-018-
3316-3
Kampragkou, C., Kampragkou, E., Kellis, E., Iakovidis, P. International Journal of Physiotherapy. (2019, 6). EFFECTS OF A 12-WEEK AEROBIC EXERCISE
PROGRAM COMBINED WITH MUSIC THERAPY AND MEMORY EXERCISES ON COGNITIVE AND FUNCTIONAL ABILITY IN PEOPLE
WITH MIDDLE TYPE OF ALZHEIMER'S DISEASE. Retrieved from https://www.ijphy.org/index.php/journal/article/view/377
Ray, K. R., Gotell, E. Frontiers in Medicine. (2018, September 9). The Use of Music and Music Therapy in Ameliorating Depression Symptoms and Improving
Well-Being in Nursing Home Residents With Dementia. Retrieved from https://doi-org.proxygsu-scob.galileo.usg.edu/10.3389/fmed.2018.00287
Satoh M., Yuba T., Tabei K., Okubo Y., Kida H., Sakuma H., Tomimoto H. Karger. (2015). Music Therapy Using Singing Training Improves Psychomotor Speed
in Patients with Alzheimer's Disease: A Neuropsychological and fMRI Study. Retrieved from https://www.karger.com/Article/FullText/436960