BLUE PRINT OF TEST QUESTIONS

DEPARTMENT OF MICROBIOLOGY AND PARASITOLOGY

I. Basic Microbiology
Bacterial morphology and Ultrastructures
Physiology, growth and nutrition
Bacterial genetics
Antimicrobial agents
Chemotherapeutic agents
Physical agents
Chemical agents
Normal Flora
Bacteria and disease

II. Immunology
Basic Immunology
Clinical Immunology

III. Bacteriology
Gram Positive Cocci
Gram negative Cocci
Anaerobes
Gram Positive Bacilli
Gram Negative Bacilli
Spirochetes
Rickettsiae
Chlamydia
Mycoplasma
Mycobacterium, Actinomycetes
Miscellaneous Bacteria

IV. Mycology
General Characteristic of fungi
Laboratory Diagnosis of Mycoses
Treatment of Mycoses
Superficial Mycoses
Systemic Mycoses

V. Virology
Basic Virology
DNA viruses
RNA viruses

VI. Clinical Microbiology

CNS Infections
Respiratory Infections
Viral Exanthems and Congenital Infections
GIT, GUT and STD infections
OUR LADY OF FATIMA UNIVERSITY-FATIMA MEDICAL SCIENCE FOUNDATION, INC.
FATIMA COLLEGE OF MEDICINE
DEPARTMENT OF MICROBIOLOGY

BASIC MICROBIOLOGY

1. Which of the following statements is INCORRECT regarding the capsules of bacteria?

A. Most gram positive have capsules and gram negative rarely do
B. Most bacterial capsules are polysaccharides
C. Bacterial capsules can be purified and used as vaccine
D. Bacterial capsules are immunogenic and as a result some bacteria have many
serologic types
2. LPS are correctly described as EXCEPT:
A. found in all gram negative bacteria of all specie
B. able to produce febrile response
C. contain lipid A responsible its antigen specificity
D. it is in the outer membrane
3. Phase in bacterial growth cycle wherein there is active metabolism but cells do not
divide
A. lag phase B. log phase D. stationary phase D. death

4. Organism that requires complex substances like amino acid as source of carbon
A. lithotrophs B. autotrophs C. heterotrophs D. A & C only
5. Any change in the base sequence of DNA
A. Inversion B. recombination C. mutation D. gene replication
6. Mating between F' & F- cells would result to
A. acquisition of maleness by the recipient cell
B. no acquisition of maleness by the recipient cell
C. acquisition of femaleness by the recipient cell
D. acquisition of maleness by the donor’s cell
7. Invasion of body by pathogens
A. contamination B. disease C. pathogenecity D. infection
8. The ffg. are associated with the autoclave,except,
A. moist heat B. live steam C.121˚C for 15-20 min D.15lb. pressure/sq. in.
9. The target or binding site of β lactam agents
A. Penicilloic acid B. Thiazolidone ring C. β lactam bond D.PBP
10. It inhibits the cross-linking of peptidoglycan
A. autolytic enzymes B. carboxypeptidase C. topoisomerase D. transpeptidase

IMMUNOLOGY

11. Deposition of immune complex in tissue

A. Type I B. Type II C. Type III D. Type IV
12. In type I hypersensitivity, the following are true:
A. production of allergen is induced by antibody C. Both
B. most cells released mediators after initial exposure D. neither
13. Antigen-binding site on T cells
A. CD4-molecule B. TCR C. IgD D. CD3 molecule
14. MHC class II are found on the surface of
A. B cellsB. macrophages C. dendritic cells D. all of the above
15. Binding of TCR CD3 complex with peptide signals:
A. B cell activation B. T cell activation C. complement activation D. none
16. Most of the autoimmune diseases are:
A. Type I B. Type II C. TypeIII D. TypeIV
17. With phagocytic defects:
A. Chronic granulomatous disease C. Di George syndrome
B. Job’s syndrome D. A and B only
18. Most useful test for Chronic Granulomatous Disease:
A. CBC B. Blood culture C. NBT D. PTH determination
19. Immune deficiency that is associated with hypocalcemia:
A. Di George B. Bruton’s C. SCID D. Job’s
20. Defective in Chediak Higashi Syndrome
A. CD18 B. Microtubules C. Chemotactic factor D. All

BACTERIOLOGY

21. Specie of Rickettsia that causes severe infection.

A. RMSF B. Ehrlichiosis C. Scrub typhus D. Typhus fever
22. Cat Scratch Disease
A. Cardiobacterium hominis C. Legionella species
B. Erysipelothrix rhisopathiae D. Bartonella henselae
23. Virulent types of N. gonorrhea
A. T1 B. T3 C. T4 D. all of the above
24. Most common clinical disease caused by gonococcus seen in males.
A. urethritis B. prostatitis C. cervicitis D. A & C only
25. Found in freshwater ponds.
A. V. vulnificus B. V. cholerae C. V. parahemolyticus D. none
26. Cell surface antigen in Salmonella, EXCEPT:
A. O B. Vi C. Both D. Neither
27. Most contagious stage of Pertussis.
A. catarrhal stage C. Convalescent stage
B. paroxysmal stage D. none
28. True of Pseudomonas aeruginosa, EXCEPT:
A. hospital acquired C. can produce pigment
B. opportunistic pathogen D. susceptible to most antibiotics
29. The most important cause of gastroenteritis involving seafoods is:
A. V. cholerae B. V. parahemolyticus C. P. aeruginosa D. B. pertussis
30. Gram (-) bacilli, “gull wing” appearance, microaerophilic
A. B. pertussis B. H. influenzae C. Campylobacter D. T. pallidium
31. Important cause of neonatal meningitis.
A. E. coli C. L. monocytogenes
B. S. agalactiae D. All of the above
32. In gonorrhea, the gram stain is very reliable for laboratory diagnosis in which group of
patients?
A. asymptomatic women C. Asymptomatic men
B. men with purulent discharge D. All of the above
33. What is responsible for the spectrum of diseases seen in SSSS?
A. exofoliatin C. sphingomyelinase C
B. leukocidin D. TSST-I
34. In cases of active PTB, the lesions on chest x-ray are located over
A. base of the lungs B. middle lobe C. apex D. whole lung
35. This lethal toxin of C. perfringens is a lecithinase which cause severe hemolysis
A. epsilon B. beta C. kappa D. iota E. alpha
36. Botulinum toxicity can cause the following EXCEPT
A. respiratory failure C. cranial nerve dysfunction
B. uncontrolled muscle contraction D. vomiting
37. Characteristic/s of M. tuberculosis
A. facultative aerobe C. grows well in lowered CO2 tension
B. hydrophobic D. all of the above
38. Blocks the release of neurotransmitters for inhibitory synapses
A. tetanospasmin B, tetanolysin C. botulinum toxin D. all of the above
39. True of B. fragilis
A. growth stimulated by bile C. implicated with pathogenesis of acne
B. sporeforming anaerobe D. all of the above
40. Dissemination of the infection in Syphilis is seen in what stage?
A. primary stage C. tertiary stage
B. secondary stage D. B & C only
41. Diagnostic test for Relapsing fever EXCEPT:
A. microscopy B. Wright stain C. serology D. culture
42. Rickettsial infection which can be transmitted by human to human contact
A. R. prowazeki B. R. Quintana C. R. typhi D. R. akarii
43. Rickettsia require living cells for its growth, except,
A. R. typhi B. E. canis C. R. Quintana D. C. burnetti
44. Which of the following statement/s is/are true?
A. All Hemophilus influenzae are pathogenic.
B. Some strains of Yersenia pestis cause disease through inhalation.
C. Both Brucella and Francisella can be transmitted by direct contact.
D. All of the above.
45. The organism which survives stomach acid by creating an ammonia cloud around it.
A. H. aegypticus B. bronchoseptica C. C. jejuni D. H. pylori
46. Gram (-) microaerophilic curved bacteria.
A. Campylobacter B. Helicobacter C. Both D. neither
47. True about tuberculosis.
A. Disease primarily due to impaired cell-mediated immunity.
B. May be acquired from contaminated unpasteurized milk.
C. The organism may dormant in macrophages without producing disease.
D. All of the above.

CASE: A 7 y/o boy complains of fever and sore throat.

48. Which of the following can cause this illness?

A. S. pyogenes B. adenovirus C. EBV D. all of the above
49. Which of the following are possible Sequelae of S. pyogenes throat infection?
A. rheumatic fever B. acute appendicitis C. both D. neither

CASE: A 1 y/o male had seizure, vomiting and cough. Meningitis was entertained. LP
showed high protein, low sugar, WBC = 1,000 with predominance of segmenters.

50. Which among the following is the gold standard for detecting the causative agent?
A. culture and sensitivity B. ELISA C. Gram staining D. All of the above

MYCOLOGY

51. When cultured at room temperature, Sporothrix schenckii is seen as:

A. tear drop-shaped conidia in flowerette arrangement C. Cigar-shaped bodies
B. tuberculate macroconidia D. sporangium
52. Lipophilic organism
A. M. furfur B. E. werneckii C. T. beigelii D. none of the above
53. Diabetic patients are prone to
A. mucormycosis B. Aspergillosis C. Candidiasis D. All of the above
54. Budding yeast cell in pilots wheel appearance
A. C. immitis B.S. schenckii C. P. brasiliensis D. C. carionii
55. The following are true of Systemic Mycoses
A. all are dimorphic B.Geographically restricted C. Transmitted by inhalation D.all

VIROLOGY

CASE: A 23 y/o female had fever, nausea, vomiting and anorexia for 4 days followed by
jaundice. Laboratory results showed SGPT 800, anti-HAV IgM (+), anti-HBC IgG negative,
anti-HbsAg(+).

56. The patient has:

A. acute hepatitis A C. carrier state for hepatitis B
B. acute hepatitis B D. acute hepatitis C
57. She most likely acquired the infection thru:
A. sexual contact C. blood transfusion
B. ingestion of fecally contaminated food or water D. kissing
58. She most likely had prior:
A. Hepatitis A infection C. Hepatitis A immunization
B. Hepatitis B infection D. Hepatitis B immunization
59. Which of the following agents of Hepatitis is an incomplete virus?
A. Hepatitis A B. Hepatitis B C. Hepatitis C D. Hepatitis D
60. These agents. Though not hepatotrophic, can also cause hepatitis:
A. Einstein Barr virus B. Cytomegalovirus C. Salmonella typhi D. All of the above

61. Progressive multifocal leukoencephalopathy is associated with

A. BK virus B. JC virus C. HSV D. Adenovirus
62. True of Poxviruses
A. acquire its envelope from the guarnieri bodies C. have multiple serotypes
B. buds out from the Guarnieri bodies D. all of the above
63. Papillomavirus serotypes associated with CA of the cervix & penis
A. 1,2,3,4 B. 6 & 11 C. 16 & 18 D. 6 & 19
64. True of HHV6:
A. closely related to gamma herpesviruses based on molecular analysis
B. based on biologic criteria similar to beta herpes viruses
 C. infects lymphocytes
D. all of the above
65. Correct statement/s regarding shingles
A. common among elderly & immunocompromised patient
B. radicular pain
C. unilateral involvement
D. all of the above
66. True statement/s regarding viruses.
A. they are cells with a true nucleus & nuclear membrane.
B. composed of only one nucleic acid.
C. can be grown in enriched media.
D. All of the above
67. Which of the following viruses have haploid nucleic acid?
A. Adenoviruses B. Picornaviruses C. Retroviruses D. All of the above
68. Confers instability to the virus.
A. viral genome B. Viral envelope C. viral capsid D. core protein
69. Correct statement/s regarding defective virus.
A. cannot replicate without the help of another virus.
B. composed of nucleic acid but lacks a protein coat
C. cannot elicit an immune or inflammatory response.
D. All of the above.
70. Which of the following statement/s is/are correct?
A. interaction of the host cell receptor & viral nucleic acid is the major determinant of
species and organ specificity.
B. viral envelope is composed of lipid derived from the host cell membrane &
protein that is virus-specific.
C. outcome of infection is dependent on the viral nucleic acid.
D. All of the above.