GROUP I (Normal)

Week 0 (Initial Data) Week 1 Week 2 Week 3

FBS FBS FBS FBS
Mice # Weight Weight Weight Weight
Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Trial 3
(g) (g) (g) (g)
I 30 125 123 143 30 130 100 121 31 171 168 160 31 117 119 113
II 34 125 116 121 34 117 111 120 35 174 172 168 34 119 124 128
III 30 180 172 145 30 167 170 174 31 184 194 174 30 145 167 143

GROUP II (Negative)
Week 0 Week 1 Week 2 Week 3
FBS FBS FBS FBS
Mice #
Weight Initial Diabetic Weight Weight Weight
(g) 1st 2nd 3rd 1st 2nd 3rd (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3
156 166 166 357 361 391
I 30 30 600 600 600 31 600 600 600 30 600 600 600
164 167 164 573 315 314
II 32 32 600 600 600 32 600 600 600 32 600 600 600
167 170 164 280 315 314
III 31 31 600 600 600 32 600 600 600 31 600 600 600

GROUP III (Positive – Glibenclamide= 5mg/kg)

Week 0 Week 1 Week 2 Week 3
FBS FBS FBS FBS
Mice # Weight Weight Weight Weight
Initial Diabetic
(g) 1st 2nd 3rd 1st 2nd 3rd (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3
526 514 510
I 30 95 96 96 28 600 600 600 30 600 600 600 31 367 358 388
119 121 120 534 576 571
II 34 32 600 600 600 34 600 600 600 34 335 348 349
123 119 108 520 539 527
III 36 33 600 600 600 35 600 600 600 36 446 482 479
 GROUP IV (High Dose Gonad Extract – 1250mg/kg)
Week 0 Week 1 Week 2 Week 3
FBS FBS FBS
Mice # Weight FBS Weight Weight Weight
(g) (g) (g) (g)
Initial Diabetic
1st 2nd 3rd 1st 2nd 3rd Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Trial 3 Trial 1 Trial 2 Trial 3
119 120 113 450 459 444
I 34 31 600 600 600 33 600 600 600 34 406 396 421
117 127 133 374 392 377
II 32 29 509 521 509 30 600 600 600 32 358 335 374
128 128 125 424 427 427
III 34 32 540 556 547 34 600 600 600 34 406 399 394

GROUP V (Low Dose Gonad Extract – 625mg/kg)

Week 0 Week 1 Week 2 Week 3
FBS FBS FBS FBS
Mice # Weight Weight Weight Weight
Initial Diabetic
(g) 1st 2nd 3rd 1st 2nd 3rd (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3
162 160 168 297 301 308
I 36 34 274 265 253 36 589 591 556 36 248 265 261
112 111 116 356 358 346
II 28 27 280 301 273 29 516 547 535 28 301 297 280
126 120 124 456 455 431
III 28 27 297 301 308 28 521 518 497 28 348 335 349

GROUP VI (High Dose Shell Extract – 1250mg/kg)

Week 0 Week 1 Week 2 Week 3
FBS FBS FBS FBS
Mice #
Weight Initial Diabetic Weight Weight Weight
(g) 1st 2nd 3rd 1st 2nd 3rd (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3
132 135 121 362 352 383
I 32 31 253 236 261 32 535 550 570 32 228 210 213
171 172 150 442 426 453
II 32 30 280 274 265 31 516 525 526 32 248 232 236
137 137 138 574 518 547
III 30 30 244 198 208 31 537 540 560 30 208 210 223
 GROUP VII (Low Dose Shell Extract – 625mg/kg)
Week 0 Week 1 Week 2 Week 3
FBS FBS FBS FBS
Mice # Weight Weight Weight Weight
Initial Diabetic
(g) 1st 2nd 3rd 1st 2nd 3rd (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3 (g) Trial 1 Trial 2 Trial 3
100 93 94 600 600 600
I 32 31 487 493 471 32 500 526 526 32 357 372 379
132 135 121 600 600 600
II 34 32 359 348 367 34 535 537 525 34 223 237 244
76 72 73 362 383 352
III 32 30 239 234 236 32 464 509 510 32 208 201 194