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Lipidmetabolism PDF
Lipidmetabolism PDF
Lipid Metabolism
Chapter 25
Table of Contents
• Chyme enters into small intestine and is emulsified with bile salts
• Pancreatic lipase hydrolyzes ester bonds to form fatty acids and glycerol
– Normally 2 out of 3 fatty acids are hydrolyzed
• Fatty acids, monoacyglycerols and bile salts make small droplets: called micelles --
hydrophobic chain in the interior
• Micelles consist of monoacyglycerols and free fatty acids:
– Small enough to absorb through intestinal cells
Copyright © Cengage Learning. All rights reserved 4
Section 25.1
Digestion and Absorption of Lipids
• In the intestinal cells monoacylglycerols and free fatty acids are
repackaged to form TAGs
• These new TAGs combine with membrane lipids (phospholipids and
cholesterol) and lipoproteins to form chylomicrons
• Chylomicrons transport TAGs from intestinal cells to the
bloodstream though the lymphatic system
• From the lymphatics the fats flow through the thoracic duct into the
bloodstream and then to the liver
• In the liver some of the fats are changed to phospholipids, so the
blood leaving the liver contains both fats and phospholipids
• These phospholipids, such as sphingomyelin and lecithin are
necessary for the formation of nerve and brain tissues
• Lecithins are also involved in the transport of fat to the tissues
• Cephalin, another phospholipid, is involved in the normal blood
clotting
• From the liver, some fat goes to the cells through the bloodstream
Copyright © Cengage Learning. All rights reserved 5
Section 25.1
Digestion and Absorption of Lipids
• In the bloodstream TAGs are completely hydrolyzed by lipase
enzymes
• Fatty acids and glycerol are absorbed by the cell and are either
broken down to the acetyl Co-A for energy or repacked to store as
lipids
• The fat in excess of what the cells need is stored in specialized cells
called adipocytes (the largest cell in the body) in the adipose tissue
– Located primarily beneath the skin especially in abdominal region and
vital organs
– Adipose tissue also serves as a protection against the heat loss and
mechanical shock
• Triacylglycerol energy reserves (fat reserves) are the human body’s
major source of stored energy:
– Energy reserves associated with protein, glycogen, and glucose are
small to very small when compared to fat reserves
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Section 25.4
Oxidation of Fatty Acids
• The acetyl CoA produced enters the citric acid cycle and the new
molecule of active fatty acid (active acyl CoA) goes through the same
sequence again, each time losing two carbon atoms until the entire
molecule has been oxidized
• The sequence presupposes the presence of fatty acids containing an
even number of carbon atoms, a condition usually encountered in
nature
• If fatty acid containing odd number of carbon atoms are oxidized they
follow the same steps except that the final products are acetyl CoA
and propionyl CoA. The propionyl CoA is changed in a series of steps
to succinyl CoA, which enters the citric acid cycle, as does the acetyl
CoA; these reactions require the presence of cobamide and biotin
• The unsaturated fatty acids are metabolized slowly; they must first be
reduced by some of the dehydrogenases found in the cells, then they
can follow the fatty acid spiral for oxidation
• The FADH2 and the NADH + H+ enter the respiratory chain
breakdown pathways