68. A process for the synthesis of 1-(4-arylpiperazine-1-yl)-3-(2-oxopyrrolidin-1-yl)propanes.

N. Sinha, S. Jain, A.K. Saxena, N. Anand, R.M. Saxena, M.P. Dubey & G.K. Patnaik.
European Patent No. 0913397 granted on 05-07-2006.

67. A process for the synthesis of novel (3S)-2-substituted 1,2,3,4-tetrahydro-9H-pyrido(3,4-

b)indole-3-carboxylic acids as potential anti-CCK agents. R.C. Tripathi, A.K. Saxena
and R. Raghubir. Indian patent file No. 0437/DEL/95 of dated 04-07-1995. Indian Patent
No. 192802 granted on 14-10-2005.

66. Substituted carbamic acid quinolin-6-yl esters as acetylcholinesterase inhibitors. Neeraj

Shakya, Z. Fatima, C. Nath, A.K. Saxena. US Patent Appl. No. PCT/IN0400427 of dated
28-12-04.

65. New 2-Alkyl / aryl sulphonyl-1, 2, 3, 4-tetrahydro-9H-pyrido(3,4-b)indole-3-carboxylic

acid esters / amides useful as antithrombotic agents for treating intravascular thrombosis,
myocardial ischemia stroke. Stuti Gaur, Z. Fatima, A. Dixit, Z. Ali, W.R. Surin, K.
Kapoor, K. Bhutani, M.S. Ansari, M. Dixit, A.K. Saxena, US Patent Appl. No.
PCT/IN0400417 of dated 27-12-04 and granted US Patent US2006142322-A1.

64. New 2-Alkyl / aryl sulphonyl-1, 2, 3, 4-tetrahydro-9H-pyrido(3,4-b)indole-3-carboxylic

acid esters / amides useful as platelet aggregation inhibitors in treatment of intravascular
thrombosis e.g. myocardial ischemia and stroke. WO2006070385-A1.

63. An improved process for the synthesis of 1-oxo-1,2,3,4,6,7,12,12a-

octahydropyrazino[2',1':6,1]-pyrido(3,4-b)indole. S.K. Pandey, K.K. Avasthi, R.C.
Tripathi, K. Bhandari, H. Thapaliyal & A.K. Saxena. Indian Patent file No. 1446/DEL/99
of dated 5-11-1999. Indian Patent No. 191499 granted on 30-06-2004.

62. Novel 1-(4-aryl/heteroarylpiperazin/piperidin-1-yl)-N-(quinoloxy-6/7/8-yl/4-

(un)substituted pyrrolidin-2-oxo-1-yl)alkanes/alkanones and their salts as potential
therapeutic agents and a process for synthesis thereof. S.K. Pandey, A. Srivastava, K.K.
Avasthi, R.C. Tripathi, S. Srivastava, J. Arun, R.M. Saxena, M. Ray, R. Shukla, M.P.
Dubey & A.K. Saxena. Indian Patent file No. 1452/DEL/99 of dated 5-11-1999. Indian
patent No. 191579 granted on 30-6-04.

61. A process for the synthesis of 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-

yl]propanes as potential therapeutic agents for hypertension, ischemia, cardiovascular and
other adrenergic receptors related disorders. Neelima Sinha, S. Jain, A.K. Saxena, N.
Anand, R.M. Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. Australian patent file
No. 23/10/97. Australian patent No. AU762684 granted on 16-10-2003.

60. 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes as potential

therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic
receptors related disorders. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand, R.M.
Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. Australian patent file No. 23/10/97.
Australian patent No. AU755526 granted on 17-4-2003.
59. 1-(4-arylpiperazin-1-y1)-.omega.-[N-(.alpha.,.omega.-dicarboximido)]-alkane s useful as
uro-selective .alpha.1-adrenoceptor blockers. N. Anand, N. Sinha, S. Jain, A. Mehta &
A.K. Saxena & J.B. Gupta. US Pat. 6,410,735 of dated June 25, 2002.

58. 1-(4-arylpiperazin-1-y1)-.omega.-[N-(.alpha.,.omega.-dicarboximido)]-alkane s useful as

uro-selective .alpha.1-adrenoceptor blockers. N. Anand, N. Sinha, S. Jain, A. Mehta &
A.K. Saxena & J.B. Gupta. US Pat. 6,420,599 of dated July 16, 2002.

57. A process for the synthesis of 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin-1-yl]propanes

from 1-chloro-3-[2-oxopyrrolidin-1-yl]propane and 1-aryl]piperazine useful as potential
hypotensive agents. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand, R.M. Saxena, M.P.
Dubey and G.K. Patnaik. Indian Patent No. 184644 granted on 04-04-2001.

56. A process for the synthesis of (3S) methyl 2-substituted 1,2,3,4-tetrahydro-9H-

pyrido(3,4-b)indole-3-carboxylate as anti-CCK agents. R.C. Tripathi, A.K. Saxena and
R. Raghubir. Indian patent No. 184304 granted on 09-02-2001.

55. 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes as potential

therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic
receptors related disorders. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand, R.M.
Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. Japanese patent file No. 10/11/97.
Japanese patent No. 3204935 granted on 15-5-2001.

54. A process for the synthesis 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-

yl]propanes as potential therapeutic agents for hypertension, ischemia, cardiovascular and
other adrenergic receptors related disorders. Neelima Sinha, S. Jain, A.K. Saxena, N.
Anand, R.M. Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. Japanese patent file
No. 23/10/97. Japanese patent No. 3204936 granted on 15-5-2001.

53. A process for the synthesis of 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-

yl]propanes used as potential therapeutic agents for hypertension, ischemia,
cardiovascular and other adrenergic receptors related disorders. Neelima Sinha, S. Jain,
A.K. Saxena, N. Anand, R.M. Saxena, M.P. Dubey, M. Ray & (late) G.K. Patnaik. US
Patent No. 6084097 granted on 04-07-2000.

52. 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes and their use in

medical treatment. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand, R.M. Saxena, M.P.
Dubey, M. Ray & (late) G.K. Patnaik. US Patent No. 6150367 granted on 21-11-2000.

51. A process for the synthesis of 1-(4-arylpiperazin-1-yl)-3-(2-oxopiperidin-1-yl)propanes

from 1-(4-arylpiperazin-1-yl)-3-chloropropanes and 2-piperidone useful as potential
hypotensive agents. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand & G.K. Patnaik.
Indian patent No. 184644 granted on 23-09-2000.

50. An improved process for the synthesis of 1-chloro-3-[2-oxopyrrolidin-1-yl]propane.

Neelima Sinha, S. Jain, A.K. Saxena and, N.Anand. Indian patent 183334 of dated 26-
05-2000.
49. A process for the synthesis of 1-[4-substituted arylpiperazin-1-yl]-3-[2-oxopyrrolidin-1-
yl]propanes from 1-[4-substituted arylpiperazin-1-yl]-3-chloropropane and 2-pyrrolidone
useful as potential hypotensive agents. Neelima Sinha, S. Jain, A.K. Saxena, N. Anand
and G.K. Patnaik. Indian patent No. 183944 granted on 24-11-2000.

48. A process for the synthesis of 1-(4-arylpiperazin-1-yl)--(2,5-dioxopyrrolidin-1-

yl)alkanes as 1-adrenoceptor blockers useful for hypertension and benign prostatic
hyperplasia (BPH). N. Anand, N. Sinha, S. Jain, A. Mehta & A.K. Saxena & J.B. Gupta.
US Pat. 6090809 of dated 18-7-2000.

47. A process for the synthesis of (1R3S) and (1S3R) alkyl substituted 1,2,3,4-tetrahydro-9H-
pyrido(3,4-b)indole-3-carboxylate as antiulcer agents. M. Saxena, R.C. Tripathi, A.K.
Saxena and G.K. Patnaik. Indian Patent No. 183332 granted on 26-05-2000.

46. A process for the preparation of novel 1-(4-aryl/heteroarylpiperazin/piperidin-1-yl)-n-

(quinoloxy-6/7/8-yl/4-(un)substituted pyrrolidin-2-oxo-1-yl)alkanes/ alkanones and their
salts as potential therapeutic agents. S.K. Pandey, A. Srivastava, K.K. Avasthi, R.C.
Tripathi, S. Srivastava, J. Arun, R.M. Saxena, M. Ray, R. Shukla, M.P. Dubey & A.K.
Saxena. Indian Patent file No. 1452/DEL/99 of dated 5-11-1999.

45. Arylpiperazine derivatives useful as uroselective 1-adrenoceptor blockers. N. Anand, N.

Sinha, S. Jain, A. Mehta & A.K. Saxena & J.B. Gupta. WO 00/05206 of dated
26.01.1999.

44. Arylpiperazine derivatives useful as uroselective 1–adrenoceptor blockers. N. Anand,

N. Sinha, S. Jain, A. Mehta & A.K. Saxena & J.B. Gupta. WO 00/05205 of dated
26.01.1999.

43. A process for the synthesis of dl-methyl 2-cyanomethyl 1,2,3,4-tetrahydro-9H-

pyrido(3,4-b)indole-3-carboxylate. A.K. Saxena. Indian Patent No. 178622 granted
16.01.98.

42. A process for the synthesis of 1-[4-arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-

yl]propanes as used as potential therapeutic agents for hypertension, ischemia,
cardiovascular and other adrenergic.A process for preparing such compounds and a
method of treating above diseases using the compounds. Neelima Sinha, S. Jain, A.K.
Saxena, N. Anand, R.M. Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. European
patent No. 97308381.9 dated 22/10/97.

41. 1-[4-Arylpiperazin-1-yl]-3-[2-oxopyrrolidin/piperidin-1-yl]propanes as potential

therapeutic agents for hypertension, ischemia, cardiovascular and other adrenergic
receptors related disorders. A process for preparing such compounds and a method of
treating above diseases using the compounds. Neelima Sinha, S. Jain, A.K. Saxena, N.
Anand, R.M. Saxena, M.P. Dubey, (late) G.K. Patnaik & M. Ray. European patent No.
97308391.8 dated 22/10/97.
40. A process for the synthesis of 1-[4-substituted arylpiperazine-1-yl]-3-[thio(4-
substituted)phenyl]propanes as potential antiinflammatory agents. J. Rao, A.K. Saxena
and R.C. Srimal. Indian Patent No. 178482 granted 26.12.97.

39. A process for the synthesis of dl-1-oxo-1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)-

pyrido(3,4-b)indole. A.K. Saxena. Indian Patent No. 178621 granted 16.01.98.

38. A process for the synthesis of dl-methyl 1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indole-3-

carboxylate. M. Saxena, J. Rao, R.C. Tripathi and A.K. Saxena. Indian Patent No.
178660 granted 23.01.98.

37. A process for the synthesis of novel trans-2-[N-(2-hydroxy-1,2,3,4-tetrahydro-1-

naphthyl)]iminothiozolidine. U.K. Shukla, A.K. Saxena, H.K. Singh, B.N. Dhawan and
N. Anand. Indian Patent No. 179230 granted on 29.05.98.

36. A process for the synthesis of novel trans-N-(2-hydroxy-1,2,3,4-tetrahydro-1-

naphthyl)thiourea. U.K. Shukla, A.K. Saxena, H.K. Singh, B.N. Dhawan and N. Anand.
Indian Patent No. 179229 granted on 29.05.98.

35. A process for the synthesis of novel trans-N-(2-hydroxy-1,2,3,4-tetrahydro-1-naphthyl)-

N'-benzoylthiourea. U.K. Shukla, A.K. Saxena, H.K. Singh, B.N. Dhawan and N. Anand.
Indian Patent No. 181872 granted on 27.08.99.
32. A process for the synthesis of 1-[4-(3-tolyl)-piperazine-1-yl]-3-[thio(4-
substituted)phenyl]propanes as potential antihypertensive agents. J. Rao, A.K. Saxena,
R.M. Saxena and R.C. Srimal. Indian Patent No. 169648 granted on 02.04.93.
31. A process for the synthesis of dl-methyl-2-substituted-1,2,3,4-tetrahydro-9H-pyrido(3,4-
b)indole-3-carboxylate as antiulcer agents. R.C. Tripathi, A.K. Saxena and G.K. Patnaik.
Indian Patent No. 170439 granted on 25.06.93.

30. A process for the synthesis of 2,7-di-r-[4-fluorobenzoylpropyl]-1,2,3,4,6,6a,7,11b,12,12a-

decahydropyrazino-[2',1':6,1]pyrido(3,4-b)indole as potential neuroleptic agent. J. Rao,
A.K. Saxena, P.R. Dua, H.N. Bhalla and G. Shankar. Indian Patent No. 168877 granted
on 22.05.92.

A process for the synthesis of dl-2-substituted 1,2,3,4-tetra-hydro-9H-pyrido(3,4-

b)indole-3-carboxylic acids as antiulcer agents. R.C. Tripathi, A.K. Saxena and G.K.
Patnaik. Indian Patent No. 168420 granted on 21.02.92.

A process for the synthesis of 2-substituted-1,2,3,4,6,6a,7,11b,12,12a-decahydropyrazino-

[2',1':6,1]pyrido(3,4-b)indole as intermediates for the synthesis of compounds having
potential pharmacological activities. J. Rao, A.K. Saxena, R.M. Saxena, P.R. Dua, R.C.
Srimal and H.N. Bhalla. Indian Patent 16642 granted on 29.1.88.

29. A process for the synthesis of 8-(4-D-hexopyranosylamino-1-methylbutylamino)-6-

methoxyquinolines as tissue schizontocides. M. Saxena, A.K. Saxena, S.K. Puri, G.P.
Dutta and N. Anand. Indian Patent 164779 granted on 19.8.86.
28. A process for the synthesis of 4,4'-bis-dimethylaminodiphenylsulphone as antimalarial
compound. M. Saxena, Z. Ali, A.K. Saxena, N. Srivastava, S. Chandra, A.B. Sen, S.K.
Puri, G.P. Dutta and N. Anand. Indian Patent 164460 granted on 26.8.86.

27. A process for the synthesis of cis-4-alkyl substituted 1,2,3,4,4a,5,6,11c-octahydro-7H-

pyrido(2,3-c)carbazole. A.K. Saxena, H.K. Singh, B.N. Dhawan and N. Anand. Indian
Patent 167493 granted on 3.12.86.

26. A process for the synthesis of cis-1-methyl 1,2,3,4,4a,5,11,11a-octahydro-6H-pyrido(3,2-

b)carbazole. A.K. Saxena, H.K. Singh, B.N. Dhawan and N. Anand. Indian Patent
165919 granted on 3.12.86.

25. A process for the synthesis of cis-4-substituted 1,2,3,4,4a,5,6,11c-octahydro-7H-

pyrido(2,3-c)carbazoles as potential dopaminergic agents. A.K. Saxena, H.K. Singh,
B.N. Dhawan and N. Anand. Indian Patent 167494 granted on 3.12.86.

24. A process for the synthesis of 1-alkyl substituted 1,2,3,4,4a,5,11,11a-octahydro-6H-

pyrido(3,2-b)carbazoles. A.K. Saxena, H.K. Singh, B.N. Dhawan and N. Anand. Indian
Patent 167492 granted on 3.12.86.

23. A Process for the synthesis of cis-1,2,3,4,4a,5,6,11,11C-octahydro-7H-pyrido(2,3-c),

carbazole as potential dopaminergic agents. A.K. Saxena, H.K. Singh, B.N. Dhawan and
N. Anand. Indian Patent 167491 granted on 3.12.86.

22. A Process for the synthesis of cis-1,2,3,4,4a,5,11,11a-octahydro-6H-pyrido(3,2-

b)carbazole as potential dopaminergic agents. A.K. Saxena, H.K. Singh,B.N. Dhawan
and N. Anand. Indian Patent 165919 granted on 3.12.86.

21. A Process for the synthesis of cis-1, benzoyl-1,2,3,4,4a,5,11,11a-octahydro-6H-

pyrido(3,2-b)carbazole and cis-4-benzoyl-1,2,3, 4,4a,5,6,11c-octahydro-7H-pyrido(2,3-
c)carbazole as potential dopaminergic agents. A.K. Saxena, H.K. Singh, B.N. Dhawan
and N. Anand. Indian Patent 165918 granted on 3.12.86.

20. A Process for the synthesis of 2,6-disubstituted-3-aryl-4(3H)pyrimidones as

antiinflammatory and CVS agents. K.A. Gupta, A.K. Saxena, P.R. Dua, R.C. Srimal and
B.N. Dhawan. Indian Patent 158084 granted on 21.9.83.

19. A process for the synthesis of 2-oxo-4-substituted pyrimido(2',1':6,1)pyrido(3,4-b)indoles

as tubal and vasal occluding agents. S.K. Agarwal, A.K. Saxena, B. Malviya, H. Chandra
and N. Anand. Indian Patent 157713 granted on 19.2.82.

18. A Process for the synthesis of 3-substituted-9H-pyrido[3,4-b]indoles as tubal and vasal

occluding agents. A.K. Saxena, S.K. Agarwal, B. Malviya, H. Chandra and N. Anand.
Indian Patent 157242 granted on 29.6.81.
17. A Process for the synthesis of 2-Aryl-S-triazino(2',1':6,1)pyrido(3,4-b)indole-4-(thione)-
as tubal and vasal occluding agents. S.K. Agarwal, A.K. Saxena, B. Malviya, H. Chandra
and N. Anand. Indian Patent 160194 granted on 22.8.81.

16. A process for the synthesis of substituted-S-triazino(2',1':6,1)pyrido(3,4-b)indoles as

tubal and vasal occluding agents. S. K. Agrawal, A.K. Saxena, B. Malviya, H. Chandra
and N. Anand. Indian Patent 160168 granted on 7.8.81.

15. A process for the synthesis of 3-substituted triazoyl-9H-pyrido[3,4-b]indoles as tubal and

vasal occluding agents. S. K. Agarwal, A.K. Saxena, B.Malviya, H.Chandra and
N.Anand. Indian. Patent 157245 granted on 25.7.81.

14. A process for the synthesis of substituted-9H-pyrido-[3,4-b]indole-3-carboxamide as

tubal and vasal occluding agents. S. K. Agarwal, A.K. Saxena, B. Malviya, H. Chandra
and N. Anand. Indian Patent 157243 granted on 25.7.81.

13. A process for the synthesis of 3-substituted-2-substituted carbomoyl or thiocarbomoyl-

9H-pyrido[3,4-b]indoles as tubal and vasal occluding agents. S.K. Agarwal, A.K.
Saxena, B. Malviya, H. Chandra and N. Anand. Ind. Patent 154380 granted on 23.6.81.

12. A process for the synthesis of 4-oxo-2,3-disubstituted pyrimido(2',1':6,1)pyrido(3,4-

b)indoles as tubal and vasal occluding agents. S.K. Agarwal, A.K. Saxena, B. Malviya,
H. Chandra and N. Anand. Indian patent file No. 160138 granted on 29.07.88.

11. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Japan Patent 91245/73 filed.

10. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Switzerland Patent 596205 granted on 15.3.78

9. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Sweden patent 73141178 granted on 11.10.79

8. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Denmark Patent 1712/74 granted on 3.10.79

7. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Australian Patent No. 61649/73.
6. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.
Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
French Patent 74,09968 dated 22.3.74; Chem. Abstr., 82, p171057w (1975) U.K. Patent
1454171 granted on 27.10.76.

5. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
French Patent 74,09968 dated 22.3.74; Chem. Abstr., 82, p171057w (1975).

4. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Canadian Patent 982132 issued on 20.1.76; Chem. Abstr., 85, p5673m (1976).

3. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh. U.S.
Patent 3,917,599 granted on 4.11.75; Chem. Abstr., 84, p164842m (1976).

2. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh. W.
German patent 2339229 granted on 2.7.75; Chem. Abstr., 82, p156373c (1975).

1. 2-Substituted 1,2,3,4,6,7,12,12a-octahydropyrazino(2',1':6,1)pyrido[3,4-b]indoles. A.K.

Saxena, P.C. Jain, P.R. Dua, R.C. Srimal, B.N. Dhawan, N. Anand and G.B. Singh.
Indian Patent 11367 granted on 30.3.76.