Questions (Pharmaceutics)

1. “Shake well” label must be placed on the containers of :

(a) Opthalmic suspension

(b) Occuserts

(c) Opthalmic solution

(d) Opthalmic gels

2. GMP regulation are pertaining to minimum requirements to be met by industry when :

(a) Manufacturing, packaging and holding of human drugs and veterinary drugs

(b) Manufacture of human drugs and veterinary drugs

(c) Manufacture and packaging of human drugs and veterinary drugs

(d) Manufacture and holding of human drugs and veterinary drugs

3. Which one of the following viscometers can be used for characterizing non-Newtonian
system?

(a) Falling sphere viscometer

(b) Cup and Bob viscometer

(c) Capillary viscometer

(d) Hoeppler viscometer

4. Movement of charged particle through a liquid under the influence of an applied potential
difference is known as

(a) Sedimentation Potential

(b) Streaming Potential

(c) Electrophoresis

(d) Electroosmosis

5. In preformulation study polymorphs can be detected by

(a) Counter - current chromatography

(b) Refractometry
(c) High performance liquid chromatography

(d) Differential scanning

6. The following is/are used to determine the amount of drug bound to a protein:

(a) Equilibrium dialysis

(b) Solubility

(c) pH titration

(d) Distribution method

7. In tablet, hydroxy propyl methyl cellulose is used as :

(a) Diluent

(b) Film former

(c) Disintegrant

(d) Binder

8. Theories of emulsification are characterized by one of the following EXCEPT:

(a) Film formation

(b) Phase inversion

(c) Monomolecular adsorption

(d) Solid particle adsorption

9. When two brands of a drug product gives same clinical results, it is termed as :

(a) Therapeutic equivalence

(b) Bio equivalence

(c) Pharmaceutical equivalence

(d) Clinical equivalence

10. Soda ash is also known as :

(a) Lime stone

(b) Sodium carbonate

(c) Pure silica

(d) Calcium carbonate

11. Microcrystalline cellulose is also called as :

(a) Sugar tab

(b) Nutab

(c) Emdex

(d) Avicel

12. Which of the following oxide is not used for achieving Amber color to glass ?

(a) Manganese

(b) Iron

(c) Cobalt

(d) Carbon

13. In case of suppositories base, SFI stands for :

(a) Solidified Fatty acid Indices

(b) Solid Fluid Indices

(c) Solidified Fatty acid Incline

(d) Solid Fat Index

14. Which polymorphic form of a drug candidate has highest melting point :

(a) Unstable

(b) Metastable

(c) Hydrates

(d) Stable

15. Volume of blood that flows per unit time per unit volume of the tissue is :

(a) Residence time

(b) Elimination rate

(c) Gastric emptying rate

(d) Perfusion rate

16. Leaching by immersion Of crude material in a solvent is also known as :

(a) Maceration

(b) Precipitation

(c) Evaporation

(d) Crystallization

17. The protein toxins that have been modified to reduce the toxicity without significantly
altering the immunogenicity are known as :

(a) Sera

(b) Antisera

(c) Toxoids

(d) Vaccines

18. The phase contrast microscopy is valuable in studying living cells which are :

(a) Stained

(b) Unstained

(c) Treated with fluorescent dye

(d) Treated with fluorescent antibody

19. Which of the following one is a broken glass & acts as fusion agent

(a) Cullet

(b) Soda ash

(c) Lime stone

(d) Sand

20. Type I glass is also known as

(a) Borosilicate glass

(b) Regular soda-lime glass

(c) Treated soda-lime glass

(d) None

21. The effect of temperature on drug stability can be described by

(a) Noyes-Whitney equation

(b) Stock’s equation

(c) Arrhenius equation

(d) None

In the tablet coating process,

22. Inadequate spreading of coating solution before drying causes

(a) Orange peel effect

(b) Sticking effect

(c) Blistering effect

(d) Picking effect

23. Pyrogens can be detected by following tests:

(a) Clarity test

(b) Leaker test

(c) LAL test

(d) Sterility test

24. Cold temperature for storage means:

(a) -20°C and -10°C

(b) 2°C and 8°C

(c) 8°C and 15°C

(d) Room temperature

25. Which method is used for validation of HEPA filter-

(a) DOP test

(b) DOD test

(c) DOC test

(d) None of the above

26. Which of the following parameters from plasma drug concentration time profile study gives
indication of rate of drug absorption:

(a) Cmax

(b) Tmax

(c) t1/2

(d) AUC

27.S.O.S means

(a) Take when necessary

(b) Take occasionaly

(c) Take immediately

(d) Take as directed

28. In the mixing of thymol and menthol the following type of incompatibility occurs :

(A) Chemical incompatibility

(B) Therapeutic incompatibility

(C) Physical incompatibility

(D) Tolerance incompatibility

29. Bloom strength is used to check the quality of

(A) Lactose

(B) Ampoules

(C) Hardness of tablets

(D)Gelatin
30. In the Drugs and Cosmetics Act and Rules, the Schedule relating to GMP is

( A) Schedule M

(B) Schedule C

(C) Schedule Y

(D) Schedule H

31. Measurement of inulin renal clearance is a measure for

(A) Effective renal blood flow

(B) Renal drug excretion rate

(C) Active renal secretion

(D) Glomerular filtration rate

32. Which filler can NOT be used for the preparation of tablets for amine containing basic drugs
to avoid discoloration of the tablets?

(A) Dicalcium phosphate

(B) Microcrystalline cellulose

(C) Starch

(D) Lactose