BOOK-BASED PATHOPHYSIOLOGY

Endothelial damage Vasospasms

Increased Fluid shifts from Increased endothelin Intravascular Increased sensitivity to

thromboxane to intravascular to & coagulation angiotensin II
prostacydin intracellular space decreased nitric oxide

Generalized Uteroplacental Glomerular Cortical Pulmonary

vasoconstric arteriole damage brain edema
tion lesions spasms

Proteinuria

Hypertension -IUGR Headache Dyspnea

-Abruption of
Edema of
placenta
the hands
-increased Hyperreflexia
face and
uterine
abdomen
contractility
(dependent) Seizure

Retinal Haemolysis Platelet Hepatic

arteriolar of RBCs aggregation micro
spasms and fibrin emboli;
deposition
Liver damage

-Blurred -Decreased Thrombocytopenia -elevated liver enzymes

vision haemoglobin -Nausea and vomiting
-Epigastric pain
-Maternal Disseminated -Right Upper Quadrant Pain
hyperbilirubinemia intravascular -Decreased blood glucose
coagulation