Sodium Hyaluronate

To treat interstitial cystitis (IC), sodium hyaluronate solution (Cystistat and Hyacyst) is
instilled directly into the bladder. Neither of these medicines are approved for use in the
United States. However, they are approved for IC treatment in the Europe and Canada.

Clinical trials tested the effectiveness of sodium hyaluronate solution, also called hyaluronic
acid, in treating IC. As a result, Cystistat is prescribed in more than 20 countries, including
the United Kingdom, Canada, Austria, France, Germany, Greece, Ireland, Italy, Netherlands,
Portugal, Scandinavia, Spain, Switzerland, China, and others. Hyacyst is also available
throughout Europe.

Dosage & Treatment Plan

Both of these products are instillations:

 Hyacyst is available in two doses (40mg and 120mg) and instillations are administered
weekly for four weeks until symptoms improve. For some patients, additional treatments
are recommended.
 Cystistat is usually instilled once a week for 4 to 6 weeks and then monthly thereafter. One
treatment is given every one or two weeks for four to eight treatments, depending on the
patient’s response to the medicine. Many patients begin to experience relief after the fifth
or sixth instillation. Some patients who respond positively may be able to increase the
interval between treatments once the symptoms have stabilized.

Potential Side Effects

Side effects are reported to be minimal, limited primarily to minor discomfort due to
catheterization, resulting in initial exacerbation of urinary frequency and urgency.

Pregnancy & Children

Because adequate and well controlled studies have not been performed in pregnant women,
the manufacturer does not recommend use of either medication during pregnancy. The safety
and effectiveness of the use of these medications in children has not been established.

You or your healthcare provider can obtain more information about:

 Cystistat by emailing info@cystistat.com.

 Hyacyst by visiting www.hyacyst.com.

Revised Monday, July 6th, 2015

Interstitial Cystitis Association

 7918 Jones Branch Drive, Suite 300 McLean, VA 22102

 icamail@ichelp.org
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Instillations Sodium Hyaluronate Sodium Hyaluronate To treat interstitial cystitis (IC),
sodium hyaluronate solution (Cystistat and Hyacyst) is instilled directly into the bladder.
Neither of these medicines are approved for use in the United States. However, they are
approved for IC treatment in the Europe and Canada. Clinical trials tested the effectiveness of
sodium hyaluronate solution, also called hyaluronic acid, in treating IC. As a result, Cystistat
is prescribed in more than 20 countries, including the United Kingdom, Canada, Austria,
France, Germany, Greece, Ireland, Italy, Netherlands, Portugal, Scandinavia, Spain,
Switzerland, China, and others. Hyacyst is also available throughout Europe. Dosage &
Treatment Plan Both of these products are instillations: Hyacyst is available in two doses
(40mg and 120mg) and instillations are administered weekly for four weeks until symptoms
improve. For some patients, additional treatments are recommended. Cystistat is usually
instilled once a week for 4 to 6 weeks and then monthly thereafter. One treatment is given
every one or two weeks for four to eight treatments, depending on the patient’s response to
the medicine. Many patients begin to experience relief after the fifth or sixth instillation.
Some patients who respond positively may be able to increase the interval between
treatments once the symptoms have stabilized. Potential Side Effects Side effects are reported
to be minimal, limited primarily to minor discomfort due to catheterization, resulting in initial
exacerbation of urinary frequency and urgency. Pregnancy & Children Because adequate and
well controlled studies have not been performed in pregnant women, the manufacturer does
not recommend use of either medication during pregnancy. The safety and effectiveness of
the use of these medications in children has not been established. You or your healthcare
provider can obtain more information about: Cystistat by emailing info@cystistat.com.
Hyacyst by visiting www.hyacyst.com. Revised Monday, July 6th, 2015 Diagnosis of IC IC
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